G9a and GLP (G9a like protein) are histone lysine methyltransferases that methylate H3K9, leading to transcriptional repression. These proteins are required for embryonic development in mice and also have roles in neuronal function and epigenetic modification of gene expression in response to repeated cocaine exposure.



Cat No Product Name / Activity
5163 A 366
Potent and selective G9a/GLP inhibitor
3364 BIX 01294
GLP and G9a inhibitor
6282 BRD 4770
G9a inhibitor and S-adenosyl methionine mimetic; cell permeable
3861 UNC 0224
Potent G9a and GLP inhibitor
4343 UNC 0638
Selective G9a and GLP inhibitor
5132 UNC 0642
Potent and selective G9a and GLP inhibitor
4342 UNC 0646
Potent and selective G9a and GLP inhibitor

G9a and GLP (G9a like protein) are histone lysine methyltransferases, also known as euchromatic histone-lysine n-methyltransferase 2 (EMHT2) and EMHT1 respectively. They exist in heteromeric complexes in vivo and lead to transcriptional repression through methylation of H3K9.

G9a or GLP knockout mice exhibit severe retardation during embryonic growth and early lethality, showing G9a/GLP H3K9 methylation is required for embryonic development. Upregulation of G9a/GLP expression is found in various human cancers and knockdown of G9a suppresses tumor cell growth in vitro and invasion of cancer cells in nude mice.

H3K9 methylation by G9a/GLP also has a role in neuronal function: postnatal forebrain neuron specific knockout of G9a results in reduced repression of nonadult neuronal genes and defects in cognition and adaptive behaviors. Additionally, G9a expression is reduced following repeated cocaine exposure in mice, regulating changes in gene expression in the nucleus accumbens.

Literature for G9a/GLP

Tocris offers the following scientific literature for G9a/GLP to showcase our products. We invite you to request* or download your copy today!

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Epigenetics Scientific Review

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