BzATP triethylammonium salt
Cat. No. 3312
Chemical Name: 2'(3')-O-(4-Benzoylbenzoyl)adenosine-
Biological ActivityPrototypic P2X7 receptor agonist that exhibits 5 - 10 fold greater potency than ATP (EC50 = 0.7 μM in HEK 293 cells; EC50 values are 3.6 and 285 μM for rat and mouse receptors respectively). Exhibits partial agonist activity at P2X1 (pEC50 = 8.7) and P2Y1 receptors and can be used as a photoaffinity label for ATPase.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Young et al (2007) Amino acid residues in the P2X7 receptor that mediate differential sensitivity fo ATP and BzATP. Mol.Pharmacol. 71 92. PMID: 17032903.
Michel et al (2001) Serum constituents can effect 2'- & 3'-O-(4-benzoylbenzoyl)-ATP potency at P2X7 receptors. Br.J.Pharmacol. 132 1501. PMID: 11264244.
Zhong et al (1998) Pharmacological and molecular characterization of P2X receptors in rat pelvic ganglion neurons. Br.J.Pharmacol. 125 771. PMID: 9831914.
Williams and Coleman (1982) Exploring the adenine nucleotide binding sites on mitochondrial F1-ATPase with a new photoaffinity probe, 3'-O-(4-Benzoyl)benzoyl adenosine 5'-triphosphate. J.Biol.Chem. 257 2834. PMID: 6460764.
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Citations are publications that use Tocris products. Selected citations for BzATP triethylammonium salt include:
Karmakar et al (2016) Neutrophil P2X7 receptors mediate NLRP3 inflammasome-dependent IL-1β secretion in response to ATP. Nat.Commun. 7 10555. PMID: 26877061.
Ilatovskaya et al (2013) Pharmacological characterization of the P2 receptors profile in the podocytes of the freshly isolated rat glomeruli. Am J Physiol Cell Physiol 305 C1050. PMID: 24048730.
Nörenberg et al (2012) Positive allosteric modulation by ivermectin of human but not murine P2X7 receptors. Br J Pharmacol 167 48. PMID: 22506590.
Woehrle et al (2010) Hypertonic stress regulates T cell function via pannexin-1 hemichannels and P2X receptors. J Leukoc Biol 88 1181. PMID: 20884646.
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Keywords: BzATP triethylammonium salt, supplier, P2Y1, partial, agonists, P2X7, P2X1, Photoaffinity, label, ATPases, P2X1/P2Y1, Receptors, Purinergic, purinoceptors, Tocris Bioscience, Fluorescent Dyes, Labels & Stain products
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