Okadaic acid

Cat. No. 1136

Okadaic acid C44H68O13 [78111-17-8]

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Chemical Name: 9,10-Deepithio-9,10-didehydroacanthifolicin

Biological Activity

Potent inhibitor of protein phosphatase 1 (IC50 = 3 nM) and protein phosphatase 2A (IC50 = 0.2-1 nM). Displays > 100,000,000-fold selectivity over PP2B and PP2C. Tumor promoter. Shown to activate atypical protein kinase C in adipocytes.

Technical Data

M.Wt:
805.01
Formula:
C44H68O13
Solubility:
Soluble to 100 mM in DMSO
Storage:
Desiccate at -20°C
CAS No:
78111-17-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Certificate of Analysis / Product Datasheet
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McCluskey et al (2002) Serine-threonine protein phosphatase inhibitors: development of therapeutic strategies. J.Med.Chem. 45 1151. PMID: 11881984.

Standaert et al (1999) Okadaic acid activates atypical protein kinase C (ζ/λ) in rat and 3T3/L1 adipocytes. J.Biol.Chem. 274 14074. PMID: 10318822.

Nuydens et al (1998) Okadaic acid-induced apoptosis in neuronal cells: evidence for an abortive mitotic attempt. J.Neurochem. 70 1124. PMID: 9489733.

Cohen et al (1990) Okadaic acid: a new probe for the study of cellular regulation. TiBS 15 98. PMID: 2158158.

Haystead et al (1989) Effects of the tumour promotor okadaic acid on intracellular protein phosphorylation and metabolism. Nature 337 78. PMID: 2562908.

Merck Index 12 6958.

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Citations are publications that use Tocris products. Selected citations for Okadaic acid include:

Cohen et al (2015) Evolutionary and functional perspectives on signaling from neuronal surface to nucleus. Neurobiol Dis 460 88. PMID: 25998737.

Polito et al (2015) Selective Effects of PDE10A Inhibitors on Striatopallidal Neurons Require Phosphatase Inhibition by DARPP-32(1,2,3). Biochem Biophys Res Commun 2. PMID: 26465004.

Martin et al (2014) IKKα negatively regulates ASC-dependent inflammasome activation. Nat Commun 5 4977. PMID: 25266676.

Bernard et al (2013) Phosphorylation of FMRP and alterations of FMRP complex underlie enhanced mLTD in adult rats triggered by early life seizures. PLoS One 59 42736. PMID: 23831253.

Brito et al (2013) Imbalance of p75(NTR)/TrkB protein expression in Huntington's disease: implication for neuroprotective therapies. Cell Death Dis 4 e595. PMID: 23598407.

Pradhan and Vijayan (2013) Lipid rafts contribute to agonist-induced serine/threonine phosphatase activation and platelet aggregation. J Neurosci 11 1612. PMID: 23789860.

Pribiag and Stellwagen (2013) TNF-α Downregulates Inhibitory Neurotransmission through Protein Phosphatase 1-Dependent Trafficking of GABAA Receptors. Mol Pain 33 15879. PMID: 24089494.

Seto et al (2013) Acute simvastatin inhibits K ATP channels of porcine coronary artery myocytes. J Neurosci 8 e66404. PMID: 23799098.

Thayer et al (2013) Increased neuronal activity fragments the Golgi complex. Proc Natl Acad Sci U S A 110 1482. PMID: 23297202.

Li and Burrell (2011) Associative, bidirectional changes in neural signaling utilizing NMDA receptor- and endocannabinoid-dependent mechanisms. Learn Mem 18 545. PMID: 21844187.

Rankovic et al (2011) Modulation of calcium-dependent inactivation of L-type Ca2+ channels via β-adrenergic signaling in thalamocortical relay neurons. PLoS One 6 e27474. PMID: 22164209.

Goffin et al (2010) Dopamine-dependent tuning of striatal inhibitory synaptogenesis. J Neurosci 30 2935. PMID: 20181591.

Li et al (2009) Activation of glycogen synthase kinase-3 β is required for hyperdopamine and D2 receptor-mediated inhibition of synaptic NMDA receptor function in the rat prefrontal cortex. Eneuro 29 15551. PMID: 20007479.

Kim et al (2008) Aberrant early-phase ERK inactivation impedes neuronal function in fragile X syndrome. J Thromb Haemost 105 4429. PMID: 18332424.

Dart and Leyland (2001) Targeting of an A kinase-anchoring protein, AKAP79, to an inwardly rectifying potassium channel, Kir2.1. J Biol Chem 276 20499. PMID: 11287423.

Do you know of a great paper that uses Okadaic acid from Tocris? If so please let us know.show all ▼show less ▲

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Keywords: Okadaic acid, supplier, Protein, phosphatase, 1, 2A, inhibitors, inhibits, Calcineurin, Ser/Thr, Phosphatases, PP1, PP2A, Tocris Bioscience, Protein Ser/Thr Phosphatases Inhibitor products

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