Okadaic acid

Cat. No. 1136

Okadaic acid C44H68O13 [78111-17-8]

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Chemical Name: 9,10-Deepithio-9,10-didehydroacanthifolicin

Biological Activity

Potent inhibitor of protein phosphatase 1 (IC50 = 3 nM) and protein phosphatase 2A (IC50 = 0.2-1 nM). Displays > 100,000,000-fold selectivity over PP2B and PP2C. Tumor promoter. Shown to activate atypical protein kinase C in adipocytes.

Technical Data

M.Wt:
805.01
Formula:
C44H68O13
Solubility:
Soluble to 100 mM in DMSO
Storage:
Desiccate at -20°C
CAS No:
78111-17-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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McCluskey et al (2002) Serine-threonine protein phosphatase inhibitors: development of therapeutic strategies. J.Med.Chem. 45 1151. PMID: 11881984.

Standaert et al (1999) Okadaic acid activates atypical protein kinase C (ζ/λ) in rat and 3T3/L1 adipocytes. J.Biol.Chem. 274 14074. PMID: 10318822.

Nuydens et al (1998) Okadaic acid-induced apoptosis in neuronal cells: evidence for an abortive mitotic attempt. J.Neurochem. 70 1124. PMID: 9489733.

Cohen et al (1990) Okadaic acid: a new probe for the study of cellular regulation. TiBS 15 98. PMID: 2158158.

Haystead et al (1989) Effects of the tumour promotor okadaic acid on intracellular protein phosphorylation and metabolism. Nature 337 78. PMID: 2562908.

Merck Index 12 6958.

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Citations are publications that use Tocris products. Selected citations for Okadaic acid include:

Martin et al (2014) IKKα negatively regulates ASC-dependent inflammasome activation. Nat Commun 5 4977. PMID: 25266676.

Brito et al (2013) Imbalance of p75(NTR)/TrkB protein expression in Huntington's disease: implication for neuroprotective therapies. Cell Death Dis 4 e595. PMID: 23598407.

Thayer et al (2013) Increased neuronal activity fragments the Golgi complex. Proc Natl Acad Sci U S A 110 1482. PMID: 23297202.

Li and Burrell (2011) Associative, bidirectional changes in neural signaling utilizing NMDA receptor- and endocannabinoid-dependent mechanisms. Learn Mem 18 545. PMID: 21844187.

Rankovic et al (2011) Modulation of calcium-dependent inactivation of L-type Ca2+ channels via β-adrenergic signaling in thalamocortical relay neurons. PLoS One 6 e27474. PMID: 22164209.

Dart and Leyland (2001) Targeting of an A kinase-anchoring protein, AKAP79, to an inwardly rectifying potassium channel, Kir2.1. J Biol Chem 276 20499. PMID: 11287423.

Do you know of a great paper that uses Okadaic acid from Tocris? If so please let us know.show all ▼show less ▲

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Keywords: Okadaic acid, supplier, Protein, phosphatase, 1, 2A, inhibitors, inhibits, Calcineurin, Ser/Thr, Phosphatases, PP1, PP2A, Tocris Bioscience, Protein Ser/Thr Phosphatases Inhibitor products

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