Cat. No. 0181
Chemical Name: trans-4-Aminocrotonic acid
Biological ActivityThe trans-isomer of CACA. Potent GABAA agonist, GABA uptake inhibitor and substrate for GABA-T. Also GABAA-ρ agonist.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Chebib et al (1997) Analogues of γ-aminobutyric acid (GABA) and trans-4-aminocrotonic acid (TACA) substituted in the 2 position as GABAC receptor antagonists. Br.J.Pharmacol. 122 1551. PMID: 9422798.
Johnston et al (1996) GABAC receptors: relatively simple transmitter-gated ion channels. TiPS 17 319. PMID: 8885697.
Johnston et al (1975) cis and trans-4-Aminocrotonic acid as GABA analogues of restricted conformation. J.Neurochem. 24 157. PMID: 234147.
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Citations are publications that use Tocris products.
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Keywords: TACA, supplier, GABAA, agonists, GABA-T, GABA, uptake, inhibitors, inhibits, GABAC, Receptors, BGT-1, GAT, Transporters, Monoamine, Neurotransmitter, Tocris Bioscience, GABAA Receptor Agonist products