Muscimol

Cat. No. 0289

Muscimol C4H6N2O2 [2763-96-4]

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Chemical Name: 5-Aminomethyl-3-hydroxyisoxazole

Biological Activity

Potent GABAA receptor agonist and partial GABAA-ρ receptor agonist. Inhibits memory retention and attenuates airway constriction in vivo.

Technical Data

M.Wt:
114.1
Formula:
C4H6N2O2
Solubility:
Soluble to 100 mM in water
Purity:
>98 %
Storage:
Store at RT
CAS No:
2763-96-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Gleason et al (2009) The GABAA agonist muscimol attenuates induced airway constriction in guinea pigs in vivo. J.Appl.Physiol. 106 1257. PMID: 19213928.

Jafari-Sabet and Jannat-Dastjerdi (2009) Muscimol state-dependent memory: involvement of dorsal hippocampal μ-opioid receptors. Behav.Brain Res. 202 5. PMID: 19447274.

Johnstone (1996) GABAC receptors: relatively simple transmitter-gated ion channels? TiPS 17 319. PMID: 8885697.

Akhondzadeh and Stone (1995) Induction of a novel form of hippocampal long-term depression by muscimol: involvement of GABAA but not glutamate receptors. Br.J.Pharmacol. 115 527. PMID: 7582468.

Johnston et al (1968) Central actions of ibotenic acid and muscimol. Biochem.Pharmacol. 17 2488. PMID: 5752907.

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Citations are publications that use Tocris products. Selected citations for Muscimol include:

Lee et al (2015) Modulation of Spinal GABAergic Inhibition and Mechanical Hypersensitivity following Chronic Compression of Dorsal Root Ganglion in the Rat. Neural Plast 2015 924728. PMID: 26451259.

Rubio et al (2015) Context-induced reinstatement of methamphetamine seeking is associated with unique molecular alterations in Fos-expressing dorsolateral striatum neurons. J Neurosci 35 5625. PMID: 25855177.

Xia et al (2014) Regulation of action potential waveforms by axonal GABAA receptors in cortical pyramidal neurons. PLoS One 9 e100968. PMID: 24971996.

Pouille et al (2013) The contribution of synaptic location to inhibitory gain control in pyramidal cells. Physiol Rep 1 e00067. PMID: 24303159.

Zagha et al (2013) Motor cortex feedback influences sensory processing by modulating network state. Neuron 79 567. PMID: 23850595.

Ring et al (2012) GABA maintains the proliferation of progenitors in the developing chick ciliary marginal zone and non-pigmented ciliary epithelium. PLoS One 7 e36874. PMID: 22590629.

Shulga et al (2012) The loop diuretic bumetanide blocks posttraumatic p75NTR upregulation and rescues injured neurons. J Neurosci 32 1757. PMID: 22302815.

Kalmbach et al (2009) Interactions between prefrontal cortex and cerebellum revealed by trace eyelid conditioning. Learn Mem 16 86. PMID: 19144967.

Yoon et al (2009) Intrathecal injection of the neurosteroid, DHEAS, produces mechanical allodynia in mice: involvement of spinal sigma-1 and GABA receptors. Br J Pharmacol 157 666. PMID: 19422393.

Manookin et al (2008) Disinhibition combines with excitation to extend the operating range of the OFF visual pathway in daylight. J Neurosci 28 4136. PMID: 18417693.

Milenković et al (2007) Development of chloride-mediated inhibition in neurons of the anteroventral cochlear nucleus of gerbil (Meriones unguiculatus). J Neurophysiol 98 1634. PMID: 17596413.

Piqueras and Martínez (2004) Peripheral GABAB agonists stimulate gastric acid secretion in mice. Br J Pharmacol 142 1038. PMID: 15210585.

Do you know of a great paper that uses Muscimol from Tocris? If so please let us know.show all ▼show less ▲

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Keywords: Muscimol, supplier, Potent, GABAA, agonists, Partial, GABAC, Receptors, Tocris Bioscience, GABAA Receptor Agonist products

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