Cat. No. 0289

Muscimol C4H6N2O2 [2763-96-4]

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Chemical Name: 5-Aminomethyl-3-hydroxyisoxazole

Biological Activity

Potent GABAA receptor agonist and partial GABAA-ρ receptor agonist. Inhibits memory retention and attenuates airway constriction in vivo.

Technical Data

Soluble to 100 mM in water
>98 %
Store at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

Certificate of Analysis / Product Datasheet
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References are publications that support the products' biological activity.

Gleason et al (2009) The GABAA agonist muscimol attenuates induced airway constriction in guinea pigs in vivo. J.Appl.Physiol. 106 1257. PMID: 19213928.

Jafari-Sabet and Jannat-Dastjerdi (2009) Muscimol state-dependent memory: involvement of dorsal hippocampal μ-opioid receptors. Behav.Brain Res. 202 5. PMID: 19447274.

Johnstone (1996) GABAC receptors: relatively simple transmitter-gated ion channels? TiPS 17 319. PMID: 8885697.

Akhondzadeh and Stone (1995) Induction of a novel form of hippocampal long-term depression by muscimol: involvement of GABAA but not glutamate receptors. Br.J.Pharmacol. 115 527. PMID: 7582468.

Johnston et al (1968) Central actions of ibotenic acid and muscimol. Biochem.Pharmacol. 17 2488. PMID: 5752907.

If you know of a relevant reference for Muscimol please let us know.

Citations are publications that use Tocris products. Selected citations for Muscimol include:

David-Pereira (2017) The medullary dorsal reticular nucleus as a relay for descending pronociception induced by the mGluR5 in the rat infralimbic cortex. Neuroscience 349 341. PMID: 28300633.

Chen et al (2016) Honokiol suppresses TNF-α-induced neutrophil adhesion on cerebral endothelial cells by disrupting polyubiquitination and degradation of IκBα. Nature 6 26554. PMID: 27212040.

Nasehi et al (2016) Additive effect of harmane and muscimol for memory consolidation impairment in inhibitory avoidance task Neuroscience 339 287. PMID: 27725215.

Arama et al (2015) GABAA receptor activity shapes the formation of inhibitory synapses between developing medium spiny neurons. PLoS One 9 290. PMID: 26300728.

Hengen et al (2015) Daily isoflurane exposure increases barbiturate insensitivity in medullary respiratory and cortical neurons via expression of η-subunit containing GABA ARs. PLoS One 10 e0119351. PMID: 25748028.

Kangarlu-Haghighi et al (2015) The effect of BLA GABA(A) receptors in anxiolytic-like effect and aversive memory deficit induced by ACPA. Sci Rep 14 613. PMID: 26648818.

Kirwan et al (2015) Development and function of human cerebral cortex neural networks from pluripotent stem cells in vitro. PLoS One 142 3178. PMID: 26395144.

Lee et al (2015) Modulation of Spinal GABAergic Inhibition and Mechanical Hypersensitivity following Chronic Compression of Dorsal Root Ganglion in the Rat. Neural Plast 2015 924728. PMID: 26451259.

Parent et al (2015) The medial prefrontal cortex is crucial for the maintenance of persistent licking and the expression of incentive contrast. Neurobiol Dis 9 23. PMID: 25870544.

Richardson and Shelton (2015) N-methyl-D-aspartate receptor channel blocker-like discriminative stimulus effects of nitrous oxide gas. Front Integr Neurosci 352 156. PMID: 25368340.

Rubio et al (2015) Context-induced reinstatement of methamphetamine seeking is associated with unique molecular alterations in Fos-expressing dorsolateral striatum neurons. J Neurosci 35 5625. PMID: 25855177.

Sivakumaran et al (2015) Selective inhibition of KCC2 leads to hyperexcitability and epileptiform discharges in hippocampal slices and in vivo. EXCLI J 35 8291. PMID: 26019342.

Taylor-Burds et al (2015) Chloride Accumulators NKCC1 and AE2 in Mouse GnRH Neurons: Implications for GABAA Mediated Excitation. J Biol Chem 10 e0131076. PMID: 26110920.

Wang et al (2015) Protein kinase C-dependent growth-associated protein 43 phosphorylation regulates gephyrin aggregation at developing GABAergic synapses. J Neurosci 35 1712. PMID: 25755278.

Pandya and Pillai (2014) TrkB interacts with ErbB4 and regulates NRG1-induced NR2B phosphorylation in cortical neurons before synaptogenesis. Neuroscience 12 47. PMID: 25052836.

Tashiro et al (2014) GABAergic influence on temporomandibular joint-responsive spinomedullary neurons depends on estrogen status. Neurobiol Learn Mem 259 53. PMID: 24316475.

Xia et al (2014) Regulation of action potential waveforms by axonal GABAA receptors in cortical pyramidal neurons. PLoS One 9 e100968. PMID: 24971996.

Maclaren et al (2013) Updating of action-outcome associations is prevented by inactivation of the posterior pedunculopontine tegmental nucleus. PLoS Comput Biol 102 28. PMID: 23567109.

Pouille et al (2013) The contribution of synaptic location to inhibitory gain control in pyramidal cells. Physiol Rep 1 e00067. PMID: 24303159.

Wagner et al (2013) The dorsomedial hypothalamus mediates stress-induced hyperalgesia and is the source of the pronociceptive peptide cholecystokinin in the rostral ventromedial medulla. Mol Cell Biol 238 29. PMID: 23415792.

Zagha et al (2013) Motor cortex feedback influences sensory processing by modulating network state. Neuron 79 567. PMID: 23850595.

Lethbridge et al (2012) Olfactory bulb glomerular NMDA receptors mediate olfactory nerve potentiation and odor preference learning in the neonate rat. Front Cell Neurosci 7 e35024. PMID: 22496886.

Ring et al (2012) GABA maintains the proliferation of progenitors in the developing chick ciliary marginal zone and non-pigmented ciliary epithelium. PLoS One 7 e36874. PMID: 22590629.

Shulga et al (2012) The loop diuretic bumetanide blocks posttraumatic p75NTR upregulation and rescues injured neurons. J Neurosci 32 1757. PMID: 22302815.

Doyon et al (2011) Efficacy of synaptic inhibition depends on multiple, dynamically interacting mechanisms implicated in chloride homeostasis. J Pharmacol Exp Ther 7 e1002149. PMID: 21931544.

Porcher et al (2011) Positive feedback regulation between γ-aminobutyric acid type A (GABA(A)) receptor signaling and brain-derived neurotrophic factor (BDNF) release in developing neurons. Neuroscience 286 21667. PMID: 21474450.

Wei et al (2011) Development of asymmetric inhibition underlying direction selectivity in the retina. J Biol Chem 469 402. PMID: 21131947.

Santhakumar et al (2010) Developmental regulation and neuroprotective effects of striatal tonic GABAA currents. Development 167 644. PMID: 20206233.

Kalmbach et al (2009) Interactions between prefrontal cortex and cerebellum revealed by trace eyelid conditioning. Learn Mem 16 86. PMID: 19144967.

Long et al (2009) Nerve Terminal GABAA Receptors Activate Ca2+/Calmodulin-dependent Signaling to Inhibit Voltage-gated Ca2+ Influx and Glutamate Release. Neuroscience 284 8726. PMID: 19141616.

Yoon et al (2009) Intrathecal injection of the neurosteroid, DHEAS, produces mechanical allodynia in mice: involvement of spinal sigma-1 and GABA receptors. Br J Pharmacol 157 666. PMID: 19422393.

Manookin et al (2008) Disinhibition combines with excitation to extend the operating range of the OFF visual pathway in daylight. J Neurosci 28 4136. PMID: 18417693.

Milenković et al (2007) Development of chloride-mediated inhibition in neurons of the anteroventral cochlear nucleus of gerbil (Meriones unguiculatus). J Neurophysiol 98 1634. PMID: 17596413.

Piqueras and Martínez (2004) Peripheral GABAB agonists stimulate gastric acid secretion in mice. Br J Pharmacol 142 1038. PMID: 15210585.

Do you know of a great paper that uses Muscimol from Tocris? If so please let us all ▼show less ▲

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Keywords: Muscimol, supplier, Potent, GABAA, agonists, Partial, GABAC, Receptors, Tocris Bioscience, GABAA Receptor Agonist products

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