MSOP

Cat. No. 0803

MSOP C4H10NO6P [66515-29-5]

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Chemical Name: (RS)-α-Methylserine-O-phosphate

Biological Activity

Selective group III metabotropic glutamate receptor antagonist. Displays an apparent KD of 51 μM for the L-AP4-sensitive presynaptic mGluR on primary afferent terminals in spinal cord compared to > 700 μM for the (1S,3S)-ACPD-sensitive presynaptic mGlu in the same system. Has no activity on postsynaptic mGlu receptors or on ionotropic glutamate receptors on neonatal rat motoneurons. Also available as part of the Group III mGlu Receptor Tocriset™.

Technical Data

M.Wt:
199.1
Formula:
C4H10NO6P
Solubility:
Soluble to 100 mM in water
Storage:
Store at RT
CAS No:
66515-29-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Certificate of Analysis / Product Datasheet
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Jane et al (1996) Phosphono substituted amino acids as selective metabotropic glutamate receptor antagonists. Phosphorous, Sulphur and Silicon 109-110 313.

Thomas et al (1996) α-Methyl derivatives of serine-O-phosphate as novel, selective competitive metabotropic glutamate receptor antagonists. Neuropharmacology 35 637. PMID: 8887973.

Thomas et al (1995) Serine-O-phosphate derivatives as novel, potent and selective metabotropic glutamate receptor (mGluR) antagonists. Soc.Neurosci.Abstr. 21 P616.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for MSOP include:

Spaziano et al (2015) Exposure to Allergen Causes Changes in NTS Neural Activities after Intratracheal Capsaicin Application, in Endocannabinoid Levels and in the Glia Morphology of NTS. Proc Natl Acad Sci U S A 2015 980983. PMID: 25866824.

Ster et al (2011) Enhancement of CA3 hippocampal network activity by activation of group II metabotropic glutamate receptors. J Neurosci 108 9993. PMID: 21628565.

Browning et al (2006) Vagal afferent control of opioidergic effects in rat brainstem circuits. Biomed Res Int 575 761. PMID: 16825311.

Derbenev et al (2006) Vanilloid-mediated heterosynaptic facilitation of inhibitory synaptic input to neurons of the rat dorsal motor nucleus of the vagus. J Physiol 26 9666. PMID: 16988037.

Melyan et al (2004) Metabotropic regulation of intrinsic excitability by synaptic activation of kainate receptors. J Neurosci 24 4530. PMID: 15140923.

Do you know of a great paper that uses MSOP from Tocris? If so please let us know.show all ▼show less ▲

View Related Products by Target

Keywords: MSOP, supplier, Specific, group, III, mGlur, antagonists, Group, Receptors, mGlu4, mGlu6, mGlu7, mGlu8, mGluR4, mGluR6, mGluR7, mGluR8, Glutamate, Metabotropic, Tocris Bioscience, Glutamate (Metabotropic) Group III Receptor Antagonist products

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