AMI-193

Cat. No. 0524

AMI-193 C22H26FN3O2 [510-74-7]

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Chemical Name: 8-[3-(4-Fluorophenoxy)propyl]-1-phenyl-1,3,8-triazaspiro[4.5]-decanone

Biological Activity

Selective 5-HT antagonist, which binds to 5-HT2 sites as potently as spiperone but has lower affinity for 5-HT2C receptors. Also a high affinity D2 receptor antagonist (Ki = 3 nM). Lacks the disruptive effect of spiperone on animal behavior.

Technical Data

M.Wt:
383.46
Formula:
C22H26FN3O2
Solubility:
Soluble to 75 mM in DMSO
Purity:
>99 %
Storage:
Store at RT
CAS No:
510-74-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Czoty et al (2000) Behavioural effects of AMI-193, a 5-HT2A- and dopamine D2-receptor antagonist, in the squirrel monkey. Pharmacol.Biochem.Behav. 67 257. PMID: 11124389.

Ismaiel et al (1993) Antagonism of 1-(2,5-dimethoxy-4-methylphenyl)-2-aminopropane stimulus with a newly identified 5HT2 versus 5HT1C selective antagonist. J.Med.Chem. 36 2519. PMID: 8355253.

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Keywords: AMI-193, supplier, Selective, 5-HT2, antagonists, D2-like, receptor, Non-Selective, Serotonin, Receptors, Dopamine, dopaminergic, Tocris Bioscience, Non-selective Dopamine Antagonist products

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