Cat. No. 0524
Chemical Name: 8-[3-(4-Fluorophenoxy)propyl]-1-phe
Biological ActivitySelective 5-HT antagonist, which binds to 5-HT2 sites as potently as spiperone but has lower affinity for 5-HT2C receptors. Also a high affinity D2 receptor antagonist (Ki = 3 nM). Lacks the disruptive effect of spiperone on animal behavior.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Czoty et al (2000) Behavioural effects of AMI-193, a 5-HT2A- and dopamine D2-receptor antagonist, in the squirrel monkey. Pharmacol.Biochem.Behav. 67 257. PMID: 11124389.
Ismaiel et al (1993) Antagonism of 1-(2,5-dimethoxy-4-methylphenyl)-2-aminopropane stimulus with a newly identified 5HT2 versus 5HT1C selective antagonist. J.Med.Chem. 36 2519. PMID: 8355253.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses AMI-193 from Tocris? If so please let us know.
View Related Products by Product Action
Keywords: AMI-193, supplier, Selective, 5-HT2, antagonists, D2-like, receptor, Non-Selective, Serotonin, Receptors, Dopamine, dopaminergic, Tocris Bioscience, Non-selective Dopamine Antagonist products