DIPPA hydrochloride

Cat. No. 0794

DIPPA hydrochloride C22H23Cl2N3OS.HCl [155512-52-0]

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Chemical Name: 2-(3,4-Dichlorophenyl)-N-methyl-N-[(1S)-1-(3-isothiocyanatophenyl)-2-(1-pyrrolidinyl)ethyl]acetamide hydrochloride

Biological Activity

An irreversible and selective antagonist at the κ receptor, with persistent effect in vivo.

Technical Data

M.Wt:
484.87
Formula:
C22H23Cl2N3OS.HCl
Solubility:
Soluble to 30 mM in ethanol and to 50 mM in DMSO
Purity:
>99 %
Storage:
Desiccate at -20°C
CAS No:
155512-52-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Certificate of Analysis / Product Datasheet
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Chang et al (1994) 2-(3,4-Dichlorophenyl)-N-methyl-N-[(1S)-1-(3-isothiocyanatophenyl)-2-(1-pyrrolidinyl)ethyl]acetamide: an opioid receptor affinity label that produces selective and long lasting κ antagonism in mice. J.Med.Chem. 37 1547. PMID: 8201586.

Chang et al (1994) κ opioid receptor selective affinity labels: Electrophilic benzeneacetamides as κ-selective opioid antagonists. J.Med.Chem. 37 4490. PMID: 7799399.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for DIPPA hydrochloride include:

Jones et al (2010) Identification of a κ-opioid agonist as a potent and selective lead for drug development against human African trypanosomiasis. Biochem Pharmacol 80 1478. PMID: 20696141.

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Keywords: DIPPA hydrochloride, supplier, Selective, irreversible, κ-opioid, kappa-opioid, antagonists, KOP, Receptors, OP2, Tocris Bioscience, κ Opioid Receptor Antagonist products

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