Cat. No. 2897
Chemical Name: 3-Hydroxynaphthalene-2-carboxylic acid (3,4-dihydroxybenzylidene)hydrazide
Biological ActivityNon-competitive inhibitor of dynamin 1, dynamin 2 and mitochondrial dynamin (Drp1) GTPase activity. Does not inhibit other small GTPases. Blocks endocytic pathways dependent on dynamin and inhibits cell spreading and migration of BSC1 cells.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Macia et al (2006) Dynasore, a cell-permeable inhibitor of Dynamin. Develop.Cell 10 839.
Newton et al (2006) Inhibition of dynamin completely blocks compensatory synaptic vesicle endocytosis. Proc.Natl.Acad.Sci.USA 103 17955.
Thompson and McNiven (2006) Discovery of a new 'dynasore'. Nat.Chem.Biol. 2 355. PMID: 16783339.
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Citations are publications that use Tocris products. Selected citations for Dynasore include:
Blume et al (2016) Cannabinoid receptor interacting protein suppresses agonist-driven CB1 receptor internalization and regulates receptor replenishment in an agonist-biased manner. J.Neurochem.. PMID: 27513693 .
Falgairolle and O'Donovan (2015) Pharmacological Investigation of Fluoro-Gold Entry into Spinal Neurons. Eur J Cell Biol 10 e0131430. PMID: 26102354.
Hoven et al (2015) eIF2α Confers Cellular Tolerance to S. aureus α-Toxin. Proc Natl Acad Sci U S A 6 383. PMID: 26284068.
Niederst et al (2015) Axonal amyloid precursor protein and its fragments undergo somatodendritic endocytosis and processing. Front Immunol 26 205. PMID: 25392299.
Nimlamool et al (2015) Connexin43 phosphorylation by PKC and MAPK signals VEGF-mediated gap junction internalization. Mol Biol Cell 26 2755. PMID: 26063728.
Lee et al (2014) Synergy between Piezo1 and Piezo2 channels confers high-strain mechanosensitivity to articular cartilage. J Neurosci 111 E5114. PMID: 25385580.
Marcello et al (2013) Endocytosis of synaptic ADAM10 in neuronal plasticity and Alzheimer's disease. J Clin Invest 123 2523. PMID: 23676497.
Pribiag and Stellwagen (2013) TNF-α Downregulates Inhibitory Neurotransmission through Protein Phosphatase 1-Dependent Trafficking of GABAA Receptors. J Neurosci 33 15879. PMID: 24089494.
Bassani et al (2012) The X-linked intellectual disability protein TSPAN7 regulates excitatory synapse development and AMPAR trafficking. Neuron 73 1143. PMID: 22445342.
Chandrasekaran et al (2012) HIV-1 Nef impairs heterotrimeric G-protein signaling by targeting Gα(i2) for degradation through ubiquitination. J Biol Chem 287 41481. PMID: 23071112.
Lowther et al (2011) Endocytosis in the mouse oocyte and its contribution to cAMP signaling during meiotic arrest. Reproduction 141 737. PMID: 21411693.
Lussier et al (2011) Activity-dependent ubiquitination of the AMPA receptor subunit GluA2. Proc Natl Acad Sci U S A 31 3077. PMID: 21414928.
Park et al (2011) A selective inhibitor of drp1, mdivi-1, increases retinal ganglion cell survival in acute ischemic mouse retina. J Neurosci 52 2837. PMID: 21372007.
Rodriguez et al (2011) Lethal iron deprivation induced by non-neutralizing antibodies targeting transferrin receptor 1 in malignant B cells. Leuk Lymphoma 52 2169. PMID: 21870996.
Zemskov et al (2011) Unconventional secretion of tissue transglutaminase involves phospholipid-dependent delivery into recycling endosomes. PLoS One 6 e19414. PMID: 21556374.
Kolpak et al (2009) Negative guidance factor-induced macropinocytosis in the growth cone plays a critical role in repulsive axon turning. Invest Ophthalmol Vis Sci 29 10488. PMID: 19710302.
Li et al (2009) Activation of glycogen synthase kinase-3 β is required for hyperdopamine and D2 receptor-mediated inhibition of synaptic NMDA receptor function in the rat prefrontal cortex. Mol Biol Cell 29 15551. PMID: 20007479.
Proszynski et al (2009) Podosomes are present in a postsynaptic apparatus and participate in its maturation. PLoS One 106 18373. PMID: 19822767.
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Keywords: Dynasore, supplier, Non-competitive, dynamin, 1, 2, mitochondrial, Drp1, inhibitors, inhibits, Mitosis, GTPases, Tocris Bioscience, GTPase Inhibitor products
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