Dynasore

Cat. No. 2897

Dynasore C18H14N2O4 [304448-55-3]

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Chemical Name: 3-Hydroxynaphthalene-2-carboxylic acid (3,4-dihydroxybenzylidene)hydrazide

Biological Activity

Non-competitive inhibitor of dynamin 1, dynamin 2 and mitochondrial dynamin (Drp1) GTPase activity. Does not inhibit other small GTPases. Blocks endocytic pathways dependent on dynamin and inhibits cell spreading and migration of BSC1 cells.

Technical Data

M.Wt:
322.32
Formula:
C18H14N2O4
Solubility:
Soluble to 100 mM in DMSO and to 5 mM in ethanol
Purity:
>99 %
Storage:
Store at -20°C
CAS No:
304448-55-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Macia et al (2006) Dynasore, a cell-permeable inhibitor of Dynamin. Develop.Cell 10 839.

Newton et al (2006) Inhibition of dynamin completely blocks compensatory synaptic vesicle endocytosis. Proc.Natl.Acad.Sci.USA 103 17955.

Thompson and McNiven (2006) Discovery of a new 'dynasore'. Nat.Chem.Biol. 2 355. PMID: 16783339.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for Dynasore include:

Nimlamool et al (2015) Connexin43 phosphorylation by PKC and MAPK signals VEGF-mediated gap junction internalization. Mol Biol Cell 26 2755. PMID: 26063728.

Marcello et al (2013) Endocytosis of synaptic ADAM10 in neuronal plasticity and Alzheimer's disease. J Clin Invest 123 2523. PMID: 23676497.

Bassani et al (2012) The X-linked intellectual disability protein TSPAN7 regulates excitatory synapse development and AMPAR trafficking. Neuron 73 1143. PMID: 22445342.

Chandrasekaran et al (2012) HIV-1 Nef impairs heterotrimeric G-protein signaling by targeting Gα(i2) for degradation through ubiquitination. J Biol Chem 287 41481. PMID: 23071112.

Lowther et al (2011) Endocytosis in the mouse oocyte and its contribution to cAMP signaling during meiotic arrest. Reproduction 141 737. PMID: 21411693.

Rodriguez et al (2011) Lethal iron deprivation induced by non-neutralizing antibodies targeting transferrin receptor 1 in malignant B cells. Leuk Lymphoma 52 2169. PMID: 21870996.

Zemskov et al (2011) Unconventional secretion of tissue transglutaminase involves phospholipid-dependent delivery into recycling endosomes. PLoS One 6 e19414. PMID: 21556374.

Do you know of a great paper that uses Dynasore from Tocris? If so please let us know.show all ▼show less ▲

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Keywords: Dynasore, supplier, Non-competitive, dynamin, 1, 2, mitochondrial, Drp1, inhibitors, inhibits, Mitosis, GTPases, Tocris Bioscience, GTPase Inhibitor products

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