(R)-(-)-Apomorphine hydrochloride

Cat. No. 2073

(R)-(-)-Apomorphine hydrochloride C17H17NO2.HCl [314-19-2]

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Chemical Name: (R)-5,6,6a,7-Tetrahydro-6-methyl-4H-dibenzo[de,g]quinoline-10,11-diol hydrochloride

Biological Activity

Prototypical dopamine agonist (pKi values are 6.43, 7.08, 7.59, 8.36 and 7.83 for human recombinant D1, D2L, D3, D4 and D5 receptors respectively). Produces biphasic effects on locomotor activity, and displays anti-Parkinsonian and neuroprotective actions following systemic administration in vivo.

Technical Data

M.Wt:
303.79
Formula:
C17H17NO2.HCl
Solubility:
Soluble to 50 mM in water and to 100 mM in DMSO
Purity:
>99 %
Storage:
Store at RT
CAS No:
314-19-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Millan et al (2002) Differential actions of antiparkinson agents at multiple classes of monoaminergic receptor. I. A multivariate analysis of the binding profiles of 14 drugs at 21 native and cloned human receptor subtypes. J.Pharmacol.Exp.Ther. 303 791. PMID: 12388666.

Grunblatt et al (1999) Apomorphine protects against MPTP-induced neurotoxicity in mice. Mov.Disord. 14 612. PMID: 10435498.

Liu et al (1996) Low doses of apomorphine suppress operant motor performance in rats. Pharmacol.Biochem.Behav. 53 335. PMID: 8808141.

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Keywords: (R)-(-)-Apomorphine hydrochloride, supplier, Dopamine, agonists, non-subtype-selective, D2, D3, D4, Non-Selective, Receptors, D1, D5, dopaminergic, Tocris Bioscience, Non-selective Dopamine Agonist products

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