Cat. No. 2073
Chemical Name: (R)-5,6,6a,7-Tetrahydro-6-methyl-4H
Biological ActivityPrototypical dopamine agonist (pKi values are 6.43, 7.08, 7.59, 8.36 and 7.83 for human recombinant D1, D2L, D3, D4 and D5 receptors respectively). Produces biphasic effects on locomotor activity, and displays anti-Parkinsonian and neuroprotective actions following systemic administration in vivo.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Millan et al (2002) Differential actions of antiparkinson agents at multiple classes of monoaminergic receptor. I. A multivariate analysis of the binding profiles of 14 drugs at 21 native and cloned human receptor subtypes. J.Pharmacol.Exp.Ther. 303 791. PMID: 12388666.
Grunblatt et al (1999) Apomorphine protects against MPTP-induced neurotoxicity in mice. Mov.Disord. 14 612. PMID: 10435498.
Liu et al (1996) Low doses of apomorphine suppress operant motor performance in rats. Pharmacol.Biochem.Behav. 53 335. PMID: 8808141.
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Keywords: (R)-(-)-Apomorphine hydrochloride, supplier, Dopamine, agonists, non-subtype-selective, D2, D3, D4, Non-Selective, Receptors, D1, D5, dopaminergic, Tocris Bioscience, Non-selective Dopamine Agonist products
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