Tocriscreen 2.0 Mini

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Description: Bioactive compound library for high-throughput screening, high-content screening and chemical biology applications; comprised of 1280 compounds (50 μL 10 mM DMSO solutions)
Datasheet
Citations (15)
Reviews
Literature (1)

Biological Activity for Tocriscreen 2.0 Mini

Tocriscreen 2.0 Mini is a library of 1280 biologically active compounds from the Tocris catalog. Covers a wide range of pharmacological targets and research areas. Compounds are supplied pre-dissolved in 50 μL 10 mM DMSO solutions.

This library replaces the Tocriscreen Plus Mini (Cat. No. 5841).

For more information on the Tocriscreen 2.0 Compound Libraries, please download our informative flyer.

If this library does not suit your needs, please submit your requirements through our Tocriscreen PRO custom compound library service.

Key Format and Product Details for Tocriscreen 2.0 Mini

  • 96-well racks with Matrix storage tubes & SepraSeal caps
  • Compounds arranged 80 per rack with 16 racks per library
  • Pre-dissolved in DMSO
  • Many compounds are exclusive to Tocris
  • Unique library with low overlap
  • Full chemical and biological data available
  • Exceptional purity
Target Classes Covered by the Tocriscreen 2.0 Compound Library

The Tocriscreen 2.0 Compound Library contains bioactive compounds covering a diverse range of molecular targets; 7-TM receptors (GPCRs; 27%), non-kinase enzymes (21%), kinases including enzyme-linked receptors (20%), ion channels (13%), cell biology targets (9%), nuclear receptors (6%), and transporters and other pharmacological targets (5%).

Request Compound List

To request a list of the compounds available in the Tocriscreen 2.0 Mini please click the request tile below. Compound lists can be provided in Excel or SD format.

Request compound list for Tocriscreen 2.0 Mini

Technical Data for Tocriscreen 2.0 Mini

Storage Store at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for Tocriscreen 2.0 Mini

Certificate of Analysis is currently unavailable on-line.
Please contact Customer Service

References for Tocriscreen 2.0 Mini

References are publications that support the biological activity of the product.

Li et al (2011) Generation of iPSCs from mouse fibroblasts with a single gene, Oct4, and small molecules. Cell Research. 21 196 PMID: 20956998

Beacham et al (2010) Cell-based potassium ion channel screening using the FluxORTM assay. J.Biomol.Screens. 15 44 PMID: 20208034

Hattori et al (2010) Small-molecule screen identifies reactive oxygen species as key regulators of neutrophil chemotaxis. Proc.Natl.Acad.Sci.USA. 107 3546 PMID: 20142487

Li et al (2015) Small-molecule-driven direct reprogramming of mouse fibroblasts into functional neurons. Cell Stem Cell. 17 195 PMID: 26253201

Yu et al (2015) Small molecules enhance CRISPR genome editing in pluripotent stem cells. Cell Stem Cell. 16 142 PMID: 25658371


If you know of a relevant reference for Tocriscreen 2.0 Mini, please let us know.

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Keywords: Tocriscreen 2.0 Mini, Tocriscreen 2.0 Mini supplier, biologically, active, pre-dissolved, DMSO, 50ul, 10mM, solutions, Tocriscreen, Compound, Collections, Screening, Library, Libraries, HTS, HCS, high, throughput, content, 7151, Tocris Bioscience

15 Citations for Tocriscreen 2.0 Mini

Citations are publications that use Tocris products. Selected citations for Tocriscreen 2.0 Mini include:

Hühn et al (2022) Prolonged estrogen deprivation triggers a broad immunosuppressive phenotype in breast cancer cells. Mol Oncol 16 148 PMID: 34392603

Gull et al (2022) Screening of chemical libraries using xenopus embryos and tadpoles for phenotypic drug discovery. Cold Spring Harb.Protoc. PMID: 36180216

Kato et al (2021) Antiviral activity of CD437 against mumps virus. Front.Microbiol. 12 751909 PMID: 34867872

Corman et al (2021) A chemical screen for modulators of mRNA translation identifies a distinct mechanism of toxicity for sphingosine kinase inhibitors PLoS Biol PMID: 34033645

Sowa et al (2020) A FRET-based high-throughput screening platform for the discovery of chemical probes targeting the scaffolding functions of human tankyrases. Sci Rep 10 12357 PMID: 32704068

Seki et al (2020) Induced pluripotent stem cell-derived monocytic cell lines from a NOMID patient serve as a screening platform for modulating NLRP3 inflammasome activity. PLoS One 15 e0237030 PMID: 32810141

Xiao et al (2020) HIV-1 fusion inhibitors targeting the membrane-proximal external region of Env spikes. Nat.Chem.Biol. 16 529 PMID: 32152540

Kato et al (2019) Identification of inhibitors of dengue viral replication using replicon cells expressing secretory luciferase. Antiviral.Res. 172 104643 PMID: 31678478

Corman et al (2019) A Chemical Screen Identifies Compounds Limiting the Toxicity of C9ORF72 Dipeptide Repeats Cell Chem Biol 26 235 PMID: 30527999

Sartori et al (2019) BIN1 recovers tauopathy-induced long-term memory deficits in mice and interacts with Tau through Thr348 phosphorylation. Acta Neuropathol 138 631 PMID: 31065832

Trogden et al (2018) An image-based small-molecule screen identifies vimentin as a pharmacologically relevant target of SimV. in cancer cells. FASEB J 32 2841 PMID: 29401610

Hermanson et al (2012) Screening for novel LRRK2 inhibitors using a high-throughput TR-FRET cellular assay for LRRK2 Ser935 phosphorylation. PLoS One 7 e43580 PMID: 22952710

Jing et al (2017) A small-molecule screen reveals that HSP90 beta promotes the conversion of induced pluripotent stem cell-derived endoderm to a hepatic fate and regulates HNF4A turnover. Development 144 1764 PMID:  28360131

Paul et al (2017) Hypothalamic regulation of regionally distinct adult neural stem cells and neurogenesis. Science 356 1383 PMID: 28619719

Fujita et al (2011) A GPR40 agonist GW9508 suppresses CCL5, CCL17, and CXCL10 induction in keratinocytes and attenuates cutaneous immune inflammation. J Invest Dermatol 131 1660 PMID: 21593768


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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Tocriscreen Compound Libraries

Tocriscreen Compound Libraries

This brochure gives an overview of the unique TocriscreenTM bioactive compound library range, including

  • Tocriscreen 2.0 Compound Library
  • Focused Tocriscreen Libraries
  • Tocriscreen FDA-approved Drug Library
  • Tocriscreen PRO Custom Service