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Submit ReviewZM 226600
Description: Kir6 (KATP) channel opener
Chemical Name: N-(4-Phenylsulfonylphenyl)-3,3,3-trifluoro-2-hydroxy-2-methylpropanamide
Biological Activity for ZM 226600
ZM 226600 is a potent Kir6 (KATP) channel opener (EC50 = 0.5 μM), devoid of antiandrogen properties.
Licensing Information
Sold with the permission of AstraZeneca UK Ltd.
Technical Data for ZM 226600
| M. Wt | 373.35 |
| Formula | C16H14F3NO4S |
| Storage | Store at RT |
| CAS Number | 147695-92-9 |
| PubChem ID | 5240098 |
| InChI Key | LJLXQHHFAKVTNP-UHFFFAOYSA-N |
| Smiles | CC(O)(C(=O)NC1=CC=C(C=C1)S(=O)(=O)C1=CC=CC=C1)C(F)(F)F |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for ZM 226600
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 37.34 | 100 |
Preparing Stock Solutions for ZM 226600
The following data is based on the product molecular weight 373.35. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.68 mL | 13.39 mL | 26.78 mL |
| 5 mM | 0.54 mL | 2.68 mL | 5.36 mL |
| 10 mM | 0.27 mL | 1.34 mL | 2.68 mL |
| 50 mM | 0.05 mL | 0.27 mL | 0.54 mL |
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Product Datasheets for ZM 226600
References for ZM 226600
References are publications that support the biological activity of the product.
Grant et al (1994) Anilide tertiary carbinols: a novel series of K+ channel openers. TiPS 15 402 PMID: 7855900
If you know of a relevant reference for ZM 226600, please let us know.
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Keywords: ZM 226600, ZM 226600 supplier, KATP, openers, Potassium, KIR, Channels, Inward, Rectifier, K+, ZM226600, AstraZeneca, Kir6, rectifier, 0882, Tocris Bioscience
Citations for ZM 226600
Citations are publications that use Tocris products.
Currently there are no citations for ZM 226600. Do you know of a great paper that uses ZM 226600 from Tocris? Please let us know.
Reviews for ZM 226600
Average Rating: 5 (Based on 1 Review.)
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ZM 226600 was used to assess Kir2.2 channel opening.
By
Anonymous on 11/29/2018
Assay Type: In Vitro
Species: Human
ZM 226600 was used to assess Kir2.2 channel opening.
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