Potent inhibitor of glutamate carboxypeptidase II and III (GCP II and III/NAAG peptidase/NAALADase) (Ki values are 0.8 and 23 nM respectively) that inhibits the hydrolysis of NAAG (IC50 = 2.4 nM). Does not directly interact with NMDA or metabotropic glutamate receptors. Reduces neuronal degeneration in a rat model of traumatic brain injury (TBI) and reduces locomotor activity in the PCP-model of schizophrenia.
Sold with the permission of Acenta Discovery, Inc.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 304.3. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||3.29 mL||16.43 mL||32.86 mL|
|5 mM||0.66 mL||3.29 mL||6.57 mL|
|10 mM||0.33 mL||1.64 mL||3.29 mL|
|50 mM||0.07 mL||0.33 mL||0.66 mL|
References are publications that support the products' biological activity.
Olszewski et al (2004) NAAG peptidase inhibition reduces locomotor activity and some stereotypes in the PCP model of schizophrenia via group II mGluR. J.Neurochem. 89 876 PMID: 15140187
Zhou et al (2005) NAAG peptidase inhibitors and their potential for diagnosis and therapy. Nat.Rev.Drug Discov. 4 1015 PMID: 16341066
Yamamoto et al (2007) Local administration of N-acetylaspartylglutamate (NAAG) peptidase inhibitors is analgesic in peripheral pain in rats. Eur.J.Neurosci. 25 147 PMID: 17241276
If you know of a relevant reference for ZJ 43, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: ZJ 43, supplier, Glutamate, carboxypeptidase, II, III, NAALADase, NAAG, peptidase, inhibitors, inhibits, Carboxypeptidase, GCP, Peptidase, Proteinases, Proteases, ZJ43, Miscellaneous, Glutamate, Carboxypeptidase, Carboxypeptidase, Tocris Bioscience
Citations for ZJ 43
Citations are publications that use Tocris products.
Currently there are no citations for ZJ 43. Do you know of a great paper that uses ZJ 43 from Tocris? If so please let us know.
Reviews for ZJ 43
There are currently no reviews for this product. Be the first to review ZJ 43 and earn rewards!
Have you used ZJ 43?
Submit a review and receive an Amazon gift card.
$10US/$10CAN/€7/£6 gift card for a review without an image
$25US/$25CAN/€18/£15 gift card for a review with an image
*Offer only valid in the USA / Canada, UK and EuropeSubmit a Review
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
New Product Guide (Spring/Summer 2018)New
Our new product guide highlights over 200 new products added to the Tocris Bioscience range during the second half of 2017.
- 7-TM Receptors
- Enzyme-Linked Receptors
- Ion Channels
- Nuclear Receptors
- Cell Metabolism
- Fluorescent Imaging
- Signal Transduction
- Stem Cells