ZJ 43

Pricing Availability Delivery Time Qty
Cat.No. 2675 - ZJ 43 | C12H20N2O7 | CAS No. 723331-20-2
Description: Glutamate carboxypeptidase II and III (NAALADase, NAAG peptidase) inhibitor
Chemical Name: N-[[[(1S)-1-Carboxy-3-methylbutyl]amino]carbonyl]-L-glutamic acid
Datasheet
Citations
Literature

Biological Activity

Potent inhibitor of glutamate carboxypeptidase II and III (GCP II and III/NAAG peptidase/NAALADase) (Ki values are 0.8 and 23 nM respectively) that inhibits the hydrolysis of NAAG (IC50 = 2.4 nM). Does not directly interact with NMDA or metabotropic glutamate receptors. Reduces neuronal degeneration in a rat model of  traumatic brain injury (TBI) and reduces locomotor activity in the PCP-model of schizophrenia.

Licensing Information

Sold with the permission of Acenta Discovery, Inc.

Technical Data

M. Wt 304.3
Formula C12H20N2O7
Storage Store at -20°C
CAS Number 723331-20-2
PubChem ID 11722553
InChI Key BSGWCSGMXAVYRT-YUMQZZPRSA-N
Smiles CC(C[C@@]([H])(C(O)=O)NC(N[C@@]([H])(CCC(O)=O)C(O)=O)=O)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 30.43 100
water 30.43 100

Preparing Stock Solutions

The following data is based on the product molecular weight 304.3. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.29 mL 16.43 mL 32.86 mL
5 mM 0.66 mL 3.29 mL 6.57 mL
10 mM 0.33 mL 1.64 mL 3.29 mL
50 mM 0.07 mL 0.33 mL 0.66 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets

Certificate of Analysis / Product Datasheet
Select another batch:
Safety Datasheet

References

References are publications that support the products' biological activity.

Olszewski et al (2004) NAAG peptidase inhibition reduces locomotor activity and some stereotypes in the PCP model of schizophrenia via group II mGluR. J.Neurochem. 89 876 PMID: 15140187

Zhou et al (2005) NAAG peptidase inhibitors and their potential for diagnosis and therapy. Nat.Rev.Drug Discov. 4 1015 PMID: 16341066

Yamamoto et al (2007) Local administration of N-acetylaspartylglutamate (NAAG) peptidase inhibitors is analgesic in peripheral pain in rats. Eur.J.Neurosci. 25 147 PMID: 17241276


If you know of a relevant reference for ZJ 43, please let us know.

View Related Products by Product Action

View all Carboxypeptidase Inhibitors

Keywords: ZJ 43, supplier, Glutamate, carboxypeptidase, II, III, NAALADase, NAAG, peptidase, inhibitors, inhibits, Carboxypeptidase, GCP, Peptidase, Proteinases, Proteases, ZJ43, Miscellaneous, Glutamate, Carboxypeptidase, Carboxypeptidase, Tocris Bioscience

Citations for ZJ 43

Citations are publications that use Tocris products.

Currently there are no citations for ZJ 43. Do you know of a great paper that uses ZJ 43 from Tocris? If so please let us know.

ZJ 43 Reviews

Average Rating:

(Based on 0 Reviews)


1 Star
0%
2 Star
0%
3 Star
0%
4 Star
0%
5 Star
0%

Have you used ZJ 43?

Submit a review and receive a $25US/€18/£15/$25CAN Amazon gift card if you include an image -$10US/€7/£6/$10CAN Amazon gift card for reviews without an image. Limited to verified customers in USA, Canada and Europe.


Literature in this Area

New Product Guide

New Product Guide (Spring/Summer 2017)

Our new product guide highlights over 130 new products added to the Tocris Bioscience range during the first half of 2017.

  • 7-TM Receptors
  • Enzymes
  • Enzyme-Linked Receptors
  • Ion Channels
  • Nuclear Receptors
  • Transporters
  • Apoptosis
  • Cell Metabolism
  • Epigenetics
  • Fluorescent Imaging
  • Signal Transduction
  • Stem Cells