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Submit ReviewZinterol hydrochloride
Description: Selective β2 agonist
Alternative Names: MJ 9184
Chemical Name: N-[5-[2-[(1,1-Dimethyl-2-phenylethyl)amino]-1-hydroxyethyl]-2-hydroxyphenyl]methanesulphonamide hydrochloride
Purity: ≥98% (HPLC)
Biological Activity for Zinterol hydrochloride
Zinterol hydrochloride is a potent and selective β2-adrenoceptor agonist (pKB values are 8.3 and < 5.7 for β 2 and β1 receptors respectively, as measured in human artery).
Technical Data for Zinterol hydrochloride
| M. Wt | 414.95 |
| Formula | C19H26N2O4S.HCl |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 38241-28-0 |
| PubChem ID | 37989 |
| InChI Key | LVNUBJDWJFOMKH-UHFFFAOYSA-N |
| Smiles | OC1=C(NS(=O)(C)=O)C=C(C(O)CNC(C)(C)CC2=CC=CC=C2)C=C1.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Zinterol hydrochloride
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 2.07 | 5 | |
| DMSO | 41.49 | 100 |
Preparing Stock Solutions for Zinterol hydrochloride
The following data is based on the product molecular weight 414.95. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.41 mL | 12.05 mL | 24.1 mL |
| 5 mM | 0.48 mL | 2.41 mL | 4.82 mL |
| 10 mM | 0.24 mL | 1.2 mL | 2.41 mL |
| 50 mM | 0.05 mL | 0.24 mL | 0.48 mL |
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Product Datasheets for Zinterol hydrochloride
References for Zinterol hydrochloride
References are publications that support the biological activity of the product.
Arvydas Skeberdis et al (1997) Beta-2 adrenergic activation of L-type Ca2+ current in cardiac myocytes. J.Pharmacol.Exp.Ther. 283 452 PMID: 9353357
Hutchinson et al (2006) Agonist effects of zinterol at the mouse and human β3-adrenoceptor. Naunyn Schmiedebergs Arch.Pharmacol. 373 158 PMID: 16601951
Kauman (1997) Four β-adrenoceptor subtypes in the mammalian heart. TiPS 18 70 PMID: 9133774
If you know of a relevant reference for Zinterol hydrochloride, please let us know.
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4 Citations for Zinterol hydrochloride
Citations are publications that use Tocris products. Selected citations for Zinterol hydrochloride include:
Schutsky et al (2011) Stress and glucocorticoids impair memory retrieval via β2-adrenergic, Gi/o-coupled suppression of cAMP signaling. J Neurosci 31 14172 PMID: 21976502
Huang et al (2018) ADRB2 polymorphism Arg16Gly modifies the natural outcome of heart failure and dictates therapeutic response to β-blockers in patients with heart failure. Cell Discov 4 57 PMID: 30374408
Macdougall et al (2012) Caveolae compartmentalise β2-adrenoceptor signals by curtailing cAMP production and maintaining phosphatase activity in the sarcoplasmic reticulum of the adult ventricular myocyte. J Mol Cell Cardiol 52 388 PMID: 21740911
Eckle et al (2008) A2B adenosine receptor signaling attenuates acute lung injury by enhancing alveolar fluid clearance in mice. J Am Coll Cardiol 118 3301 PMID: 18787641
Do you know of a great paper that uses Zinterol hydrochloride from Tocris? Please let us know.
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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