Potent and selective β2-adrenoceptor agonist (pKB values are 8.3 and < 5.7 for β 2 and β1 receptors respectively, as measured in human artery).
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 414.95. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.41 mL||12.05 mL||24.1 mL|
|5 mM||0.48 mL||2.41 mL||4.82 mL|
|10 mM||0.24 mL||1.2 mL||2.41 mL|
|50 mM||0.05 mL||0.24 mL||0.48 mL|
References are publications that support the biological activity of the product.
Arvydas Skeberdis et al (1997) Beta-2 adrenergic activation of L-type Ca2+ current in cardiac myocytes. J.Pharmacol.Exp.Ther. 283 452 PMID: 9353357
Hutchinson et al (2006) Agonist effects of zinterol at the mouse and human β3-adrenoceptor. Naunyn Schmiedebergs Arch.Pharmacol. 373 158 PMID: 16601951
Kauman (1997) Four β-adrenoceptor subtypes in the mammalian heart. TiPS 18 70 PMID: 9133774
If you know of a relevant reference for Zinterol hydrochloride, please let us know.
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3 Citations for Zinterol hydrochloride
Citations are publications that use Tocris products. Selected citations for Zinterol hydrochloride include:
Eckle et al (2008) A2B adenosine receptor signaling attenuates acute lung injury by enhancing alveolar fluid clearance in mice. J Am Coll Cardiol 118 3301 PMID: 18787641
Macdougall et al (2012) Caveolae compartmentalise β2-adrenoceptor signals by curtailing cAMP production and maintaining phosphatase activity in the sarcoplasmic reticulum of the adult ventricular myocyte. J Mol Cell Cardiol 52 388 PMID: 21740911
Schutsky et al (2011) Stress and glucocorticoids impair memory retrieval via β2-adrenergic, Gi/o-coupled suppression of cAMP signaling. J Neurosci 31 14172 PMID: 21976502
Do you know of a great paper that uses Zinterol hydrochloride from Tocris? Please let us know.
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
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Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.