Zinterol hydrochloride

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Cat.No. 1051 - Zinterol hydrochloride | C19H26N2O4S | CAS No. 37000-20-7
Description: Selective β2 agonist
Alternative Names: MJ 9184
Chemical Name: N-[5-[2-[(1,1-Dimethyl-2-phenylethyl)amino]-1-hydroxyethyl]-2-hydroxyphenyl]methanesulphonamide hydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations (3)
Reviews
Literature

Biological Activity

Potent and selective β2-adrenoceptor agonist (pKB values are 8.3 and < 5.7 for β 2 and β1 receptors respectively, as measured in human artery).

Technical Data

M. Wt 414.95
Formula C19H26N2O4S
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 37000-20-7
PubChem ID 37989
InChI Key LVNUBJDWJFOMKH-UHFFFAOYSA-N
Smiles OC1=C(NS(=O)(C)=O)C=C(C(O)CNC(C)(C)CC2=CC=CC=C2)C=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 2.07 5
DMSO 41.49 100

Preparing Stock Solutions

The following data is based on the product molecular weight 414.95. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.41 mL 12.05 mL 24.1 mL
5 mM 0.48 mL 2.41 mL 4.82 mL
10 mM 0.24 mL 1.2 mL 2.41 mL
50 mM 0.05 mL 0.24 mL 0.48 mL

Molarity Calculator

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Arvydas Skeberdis et al (1997) Beta-2 adrenergic activation of L-type Ca2+ current in cardiac myocytes. J.Pharmacol.Exp.Ther. 283 452 PMID: 9353357

Hutchinson et al (2006) Agonist effects of zinterol at the mouse and human β3-adrenoceptor. Naunyn Schmiedebergs Arch.Pharmacol. 373 158 PMID: 16601951

Kauman (1997) Four β-adrenoceptor subtypes in the mammalian heart. TiPS 18 70 PMID: 9133774


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3 Citations for Zinterol hydrochloride

Citations are publications that use Tocris products. Selected citations for Zinterol hydrochloride include:

Eckle et al (2008) A2B adenosine receptor signaling attenuates acute lung injury by enhancing alveolar fluid clearance in mice. J Am Coll Cardiol 118 3301 PMID: 18787641

Macdougall et al (2012) Caveolae compartmentalise β2-adrenoceptor signals by curtailing cAMP production and maintaining phosphatase activity in the sarcoplasmic reticulum of the adult ventricular myocyte. J Mol Cell Cardiol 52 388 PMID: 21740911

Schutsky et al (2011) Stress and glucocorticoids impair memory retrieval via β2-adrenergic, Gi/o-coupled suppression of cAMP signaling. J Neurosci 31 14172 PMID: 21976502


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Literature in this Area

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