Zimelidine dihydrochloride

Discontinued Product

Zimelidine dihydrochloride (Cat. No. 1767) has been withdrawn from sale for commercial reasons.
Description: Selective 5-HT uptake inhibitor
Chemical Name: (2Z)-3-(4-Bromophenyl)-N,N-dimethyl-3-(3-pyrindinyl)-2-propen-1-amine dihydrochloride
Purity: ≥98% (HPLC)
Citations (1)
Literature (1)

Biological Activity for Zimelidine dihydrochloride

5-HT re-uptake inhibitor; selective over noradrenalin and dopamine uptake (IC50 values are 0.33, 8.2 and 12 μM respectively). Modulates nociception and induces hyperglycemia in vivo, and is an orally active antidepressant.

Technical Data for Zimelidine dihydrochloride

M. Wt 390.15
Formula C16H17BrN2.2HCl
Storage Desiccate at RT
Purity ≥98% (HPLC)
CAS Number 60525-15-7
PubChem ID 6436006
Smiles Cl[H].Cl[H].CN(C)C\C=C(\C1=CC=C(Br)C=C1)C1=CC=CN=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for Zimelidine dihydrochloride

References for Zimelidine dihydrochloride

References are publications that support the biological activity of the product.

Ogren et al (1981) The pharmacology of zimelidine: a 5-HT selective reuptake inhibitor. Acta Psychiatr.Scand.Suppl. 290 127 PMID: 6452789

Fasmer et al (1987) Changes in nociception after acute and chronic administration of zimelidine: different effects in the formalin test and substance P behavioural assay. Neuropharmacology 26 309 PMID: 2438584

Sugimoto et al (1999) Involvement of serotonin in zimelidine-induced hyperglycemia in mice. Biol.Pharm.Bull. 22 1240 PMID: 10598036

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Keywords: Zimelidine dihydrochloride, Zimelidine dihydrochloride supplier, Selective, 5-HT, reuptake, inhibitors, inhibits, Serotonin, Transporters, SERT, 5-Hydroxytryptamine, Monoamine, Neurotransmitter, 1767, Tocris Bioscience

1 Citation for Zimelidine dihydrochloride

Citations are publications that use Tocris products. Selected citations for Zimelidine dihydrochloride include:

Kim et al (2009) A novel flow cytometric high throughput assay for a systematic study on molecular mechanisms underlying T cell receptor-mediated integrin activation. PLoS One 4 e6044 PMID: 19557182

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

5-HT Receptors Scientific Review

5-HT Receptors Scientific Review

Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.