Zimelidine dihydrochloride

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Cat.No. 1767 - Zimelidine dihydrochloride | C16H17BrN2.2HCl | CAS No. 60525-15-7
Description: Selective 5-HT uptake inhibitor
Chemical Name: (2Z)-3-(4-Bromophenyl)-N,N-dimethyl-3-(3-pyrindinyl)-2-propen-1-amine dihydrochloride
Purity: ≥98% (HPLC)
Citations (1)

Biological Activity

5-HT re-uptake inhibitor; selective over noradrenalin and dopamine uptake (IC50 values are 0.33, 8.2 and 12 μM respectively). Modulates nociception and induces hyperglycemia in vivo, and is an orally active antidepressant.

Technical Data

M. Wt 390.15
Formula C16H17BrN2.2HCl
Storage Desiccate at RT
Purity ≥98% (HPLC)
CAS Number 60525-15-7
PubChem ID 6436006
Smiles Cl[H].Cl[H].CN(C)C\C=C(\C1=CC=C(Br)C=C1)C1=CC=CN=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
water 31.72 100
phosphate buffered saline 31.72 100

Preparing Stock Solutions

The following data is based on the product molecular weight 390.15. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.56 mL 12.82 mL 25.63 mL
5 mM 0.51 mL 2.56 mL 5.13 mL
10 mM 0.26 mL 1.28 mL 2.56 mL
50 mM 0.05 mL 0.26 mL 0.51 mL

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Product Datasheets

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References are publications that support the products' biological activity.

Ogren et al (1981) The pharmacology of zimelidine: a 5-HT selective reuptake inhibitor. Acta Psychiatr.Scand.Suppl. 290 127 PMID: 6452789

Fasmer et al (1987) Changes in nociception after acute and chronic administration of zimelidine: different effects in the formalin test and substance P behavioural assay. Neuropharmacology 26 309 PMID: 2438584

Sugimoto et al (1999) Involvement of serotonin in zimelidine-induced hyperglycemia in mice. Biol.Pharm.Bull. 22 1240 PMID: 10598036

If you know of a relevant reference for Zimelidine dihydrochloride, please let us know.

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1 Citation for Zimelidine dihydrochloride

Citations are publications that use Tocris products. Selected citations for Zimelidine dihydrochloride include:

Kim et al (2009) A novel flow cytometric high throughput assay for a systematic study on molecular mechanisms underlying T cell receptor-mediated integrin activation. PLoS One 4 e6044 PMID: 19557182

Do you know of a great paper that uses Zimelidine dihydrochloride from Tocris? If so please let us know.

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