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Description: Potent influenza virus neuraminidase inhibitor
Chemical Name: 5-(Acetylamino)-4-[(aminoiminomethyl)amino]-2,6-anhydro-3,4,5-trideoxy-5-(Acetylamino)-4-[(aminoiminomethyl)amino]-2,6-anhydro-3,4,5-trideoxy-D-glycero-D-galactonon-2-enonic acid-glycero-D-galactonon-2-enonic acid
Purity: ≥98% (HPLC)

Biological Activity for Zanamivir

Zanamivir is an influenza viral neuraminidase inhibitor (IC50 values are 0.95 nM and 2.7 nM for influenza A and B, respectively). Inhibits neuraminidase, preventing the cleavage of sialic acid on the cell receptors, and release of the newly formed virions.

Technical Data for Zanamivir

M. Wt 332.31
Formula C12H20N4O7
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 139110-80-8
PubChem ID 60855
Smiles [H][C@]1(OC(=C[C@H](NC(N)=N)[C@H]1NC(C)=O)C(O)=O)[C@H](O)[C@H](O)CO

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Zanamivir

Solvent Max Conc. mg/mL Max Conc. mM
water 1.66 5

Preparing Stock Solutions for Zanamivir

The following data is based on the product molecular weight 332.31. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.05 mM 60.18 mL 300.92 mL 601.85 mL
0.25 mM 12.04 mL 60.18 mL 120.37 mL
0.5 mM 6.02 mL 30.09 mL 60.18 mL
2.5 mM 1.2 mL 6.02 mL 12.04 mL

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References for Zanamivir

References are publications that support the biological activity of the product.

Gubareva et al (2001) Comparison of the activities of zanamivir, oseltamivir, and RWJ-270201 against clinical isolates of influenza virus and neuraminidase inhibitor-resistant variants. Antimicrob.Agents Chemother. 45 3403 PMID: 11709315

Elliott et al (2001) Zanamivir: from drug design to the clinic. Philos.Trans.R.Soc.Lond.B.Biol.Sci. 356 1885 PMID: 11779388

McKimm-Breschkin et al (2005) Management of influenza virus infections with neuraminidase inhibitors: detection, incidence, and implications of drug resistance. Treat Respir.Med. 4 107 PMID: 15813662

If you know of a relevant reference for Zanamivir, please let us know.

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Keywords: Zanamivir, Zanamivir supplier, influenza, flu, viral, neuraminidases, inhibitors, inhibits, covid-19, covid19, Other, Hydrolases, COVID-19, Influenza, Viruses, 7187, Tocris Bioscience

Citations for Zanamivir

Citations are publications that use Tocris products.

Currently there are no citations for Zanamivir. Do you know of a great paper that uses Zanamivir from Tocris? Please let us know.

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