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Influenza viral neuraminidase inhibitor (IC50 values are 0.95 nM and 2.7 nM for influenza A and B, respectively). Inhibits neuraminidase, preventing the cleavage of sialic acid on the cell receptors, and release of the newly formed virions.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 332.31. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.05 mM||60.18 mL||300.92 mL||601.85 mL|
|0.25 mM||12.04 mL||60.18 mL||120.37 mL|
|0.5 mM||6.02 mL||30.09 mL||60.18 mL|
|2.5 mM||1.2 mL||6.02 mL||12.04 mL|
References are publications that support the biological activity of the product.
Gubareva et al (2001) Comparison of the activities of zanamivir, oseltamivir, and RWJ-270201 against clinical isolates of influenza virus and neuraminidase inhibitor-resistant variants. Antimicrob.Agents Chemother. 45 3403 PMID: 11709315
Elliott et al (2001) Zanamivir: from drug design to the clinic. Philos.Trans.R.Soc.Lond.B.Biol.Sci. 356 1885 PMID: 11779388
McKimm-Breschkin et al (2005) Management of influenza virus infections with neuraminidase inhibitors: detection, incidence, and implications of drug resistance. Treat Respir.Med. 4 107 PMID: 15813662
If you know of a relevant reference for Zanamivir, please let us know.
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Literature in this Area
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