Z-YVAD-FMK

Discontinued Product

Z-YVAD-FMK (Cat. No. 2164) has been withdrawn from sale for commercial reasons.
Cat.No. 2164 - Z-YVAD-FMK | Z-Tyr-Val-Ala-Asp(OMe)-fluoromethylketone
Description: Caspase-1 (ICE) inhibitor
Chemical Name: Benzyloxycarbonyl-Tyr-Val-Ala-Asp(OMe)-fluoromethylketone
Datasheet
Citations
Reviews
Literature

Biological Activity

Inhibitor of caspase-1 (ICE); inhibits apoptosis.

Technical Data

M. Wt 630.67
Formula C31H39FN4O9
Sequence YVAD

(Modifications: Tyr-1 = Z-Tyr, Asp-4 = (OMe)-fluoromethylketone)

Storage Store at -20°C
Smiles [H]N([C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(=O)OC)C(=O)CF)C(=O)OCC1=CC=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References

References are publications that support the biological activity of the product.

Avivi-Green et al (2002) Different molecular events account for butyrate-induced apoptosis in two human colon cancer cell lines. J.Nutr. 132 1812 PMID: 12097652

Ming et al (2002) Caspase-1 expression in multiple sclerosis plaques and cultured glial cells. J.Neurol.Sci. 197 9 PMID: 11997061

Winter et al (2004) Caspase-1 enhances the apoptotic response of prostate cancer cells to ionizing radiation. Anticancer Res. 24 1377 PMID: 15274298

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Keywords: Z-YVAD-FMK, Z-YVAD-FMK supplier, Caspase-1, ICE, inhibitors, inhibits, Caspases, Proteinases, Proteases, 2164, Tocris Bioscience

Citations for Z-YVAD-FMK

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Cancer

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  • Epigenetics in Cancer
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  • Angiogenesis
  • Invasion and Metastasis
Neurodegeneration

Neurodegeneration Product Guide

A collection of over 275 products for neurodegeneration research, the guide includes research tools for the study of:

  • Alzheimer's disease
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Cell Cycle & DNA Damage Repair

Cell Cycle & DNA Damage Repair Poster

In normal cells, each stage of the cell cycle is tightly regulated, however in cancer cells many genes and proteins that are involved in the regulation of the cell cycle are mutated or over expressed. Adapted from the 2015 Cancer Product Guide, Edition 3, this poster summarizes the stages of the cell cycle and DNA repair. It also highlights strategies for enhancing replicative stress in cancer cells to force mitotic catastrophe and cell death.

Huntington's Disease

Huntington's Disease Poster

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Parkinson's

Parkinson's Poster

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Programmed Cell Death

Programmed Cell Death Poster

There are two currently recognized forms of programmed cell death: apoptosis and necroptosis. This poster summarizes the signaling pathways involved in apoptosis, necroptosis and cell survival following death receptor activation, and highlights the influence of the molecular switch, cFLIP, on cell fate.