Discontinued ProductUnfortunately Z-VEID-FMK (Cat. No. 2169) has been withdrawn from sale for commercial reasons.
Irreversible caspase-6 inhibitor. Inhibits nuclear protein cleavage in Fas antibody-treated HeLa cells.
(Modifications: Val-1 = Z-Val, Glu-2 = Glu(OMe), Asp-4 = (OMe)-fluoromethylketone)
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Preparing Stock Solutions
The following data is based on the product molecular weight 652.72. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.53 mL||7.66 mL||15.32 mL|
|5 mM||0.31 mL||1.53 mL||3.06 mL|
|10 mM||0.15 mL||0.77 mL||1.53 mL|
|50 mM||0.03 mL||0.15 mL||0.31 mL|
References are publications that support the products' biological activity.
Abdo et al (2003) Role of tumor necrosis factor-alpha and the modulating effect of the caspases in rat corpus luteum apoptosis. Biol.Reprod. 68 1241 PMID: 12606464
Nyormoi et al (2003) Sequence-based discovery of a synthetic peptide inhibitor of caspase 6. Apoptosis 8 371 PMID: 12815280
Taimen and Kallajoki (2003) NuMA and nuclear lamins behave differently in Fas-mediated apoptosis. J.Cell Sci. 116 571 PMID: 12508117
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Keywords: Z-VEID-FMK, supplier, Irreversible, caspase-6, inhibitors, inhibits, Caspases, Proteinases, Proteases, Caspases, Caspases, Tocris Bioscience
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