Discontinued Product

Z-VEID-FMK (Cat. No. 2169) has been withdrawn from sale for commercial reasons.
Cat.No. 2169 - Z-VEID-FMK | Z-Val-Glu(OMe)-Ile-Asp(OMe)-fluoromethylketone
Description: Irreversible caspase-6 inhibitor
Chemical Name: Benzyloxycarbonyl-Val-Glu(OMe)-Ile-Asp(OMe)-fluoromethylketone
Literature (6)

Biological Activity for Z-VEID-FMK

Irreversible caspase-6 inhibitor. Inhibits nuclear protein cleavage in Fas antibody-treated HeLa cells.

Technical Data for Z-VEID-FMK

M. Wt 652.72
Formula C31H45FN4O10
Sequence VEID

(Modifications: Val-1 = Z-Val, Glu-2 = Glu(OMe), Asp-4 = (OMe)-fluoromethylketone)

Storage Store at -20°C
Smiles [H]N([C@@H](C(C)C)C(=O)N[C@@H](CCC(=O)OC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(=O)OC)C(=O)CF)C(=O)OCC1=CC=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for Z-VEID-FMK

References are publications that support the biological activity of the product.

Abdo et al (2003) Role of tumor necrosis factor-alpha and the modulating effect of the caspases in rat corpus luteum apoptosis. Biol.Reprod. 68 1241 PMID: 12606464

Nyormoi et al (2003) Sequence-based discovery of a synthetic peptide inhibitor of caspase 6. Apoptosis 8 371 PMID: 12815280

Taimen and Kallajoki (2003) NuMA and nuclear lamins behave differently in Fas-mediated apoptosis. J.Cell Sci. 116 571 PMID: 12508117

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Keywords: Z-VEID-FMK, Z-VEID-FMK supplier, Irreversible, caspase-6, inhibitors, inhibits, Caspases, Proteinases, Proteases, 2169, Tocris Bioscience

Citations for Z-VEID-FMK

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Currently there are no citations for Z-VEID-FMK.

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Literature in this Area

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