Discontinued ProductUnfortunately Z-VDVAD-FMK (Cat. No. 2165) has been withdrawn from sale for commercial reasons.
Irreversible caspase-2 inhibitor. Attenuates oxyhemoglobin-induced cleavage of PARP and apoptosis in endothelial cells.
(Modifications: Val-1 = Z-Val, Aps-2 = Asp(OMe), Asp-5 = (OMe)-fluoromethylketone)
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Preparing Stock Solutions
The following data is based on the product molecular weight 695.74. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.44 mL||7.19 mL||14.37 mL|
|5 mM||0.29 mL||1.44 mL||2.87 mL|
|10 mM||0.14 mL||0.72 mL||1.44 mL|
|50 mM||0.03 mL||0.14 mL||0.29 mL|
References are publications that support the products' biological activity.
Gamen et al (2000) Doxorubicin treatment activates a Z-VAD-sensitive caspase, which causes Dym loss, caspase-9 activity, and apoptosis in Jurkat cells. Exp.Cell Res. 258 223 PMID: 10912804
Meguro et al (2001) Caspase inhibitors attenuate oxyhemoglobin-induced apoptosis in endothelial cells. Stroke 32 561 PMID: 11157197
Robertson et al (2002) Caspase-2 acts upstream of mitochondria to promote cytochrome c release during etoposide-induced apoptosis. J.Biol.Chem. 277 29803 PMID: 12065594
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Keywords: Z-VDVAD-FMK, supplier, Irreversible, caspase-2, inhibitors, inhibits, Caspases, Proteinases, Proteases, Caspases, Caspases, Tocris Bioscience
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