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Discontinued ProductZ-VDVAD-FMK (Cat. No. 2165) has been withdrawn from sale for commercial reasons.
Biological Activity for Z-VDVAD-FMK
Irreversible caspase-2 inhibitor. Attenuates oxyhemoglobin-induced cleavage of PARP and apoptosis in endothelial cells.
Technical Data for Z-VDVAD-FMK
(Modifications: Val-1 = Z-Val, Aps-2 = Asp(OMe), Asp-5 = (OMe)-fluoromethylketone)
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
References for Z-VDVAD-FMK
References are publications that support the biological activity of the product.
Gamen et al (2000) Doxorubicin treatment activates a Z-VAD-sensitive caspase, which causes Dym loss, caspase-9 activity, and apoptosis in Jurkat cells. Exp.Cell Res. 258 223 PMID: 10912804
Meguro et al (2001) Caspase inhibitors attenuate oxyhemoglobin-induced apoptosis in endothelial cells. Stroke 32 561 PMID: 11157197
Robertson et al (2002) Caspase-2 acts upstream of mitochondria to promote cytochrome c release during etoposide-induced apoptosis. J.Biol.Chem. 277 29803 PMID: 12065594
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Keywords: Z-VDVAD-FMK, Z-VDVAD-FMK supplier, Irreversible, caspase-2, inhibitors, inhibits, Caspases, Proteinases, Proteases, 2165, Tocris Bioscience
Citations for Z-VDVAD-FMK
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Currently there are no citations for Z-VDVAD-FMK.
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Cell Cycle and DNA Damage Research Product Guide
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There are two currently recognized forms of programmed cell death: apoptosis and necroptosis. This poster summarizes the signaling pathways involved in apoptosis, necroptosis and cell survival following death receptor activation, and highlights the influence of the molecular switch, cFLIP, on cell fate.