YM 511

Discontinued Product

YM 511 (Cat. No. 3278) has been withdrawn from sale for commercial reasons.
Description: Potent aromatase (CYP19) inhibitor
Chemical Name: 4-[[(4-Bromophenyl)methyl]-4H-1,2,4-triazol-4-ylamino]benzonitrile
Purity: ≥99% (HPLC)
Datasheet
Citations
Reviews

Biological Activity for YM 511

YM 511 is an orally active, potent aromatase (CYP19) inhibitor (IC50 values are 0.4 and 0.12 nM at rat ovary and human placenta cells respectively) that only weakly inhibits the synthesis of other steroid hormones. Reduces plasma estrogen levels into ranges induced by ovariectomy and inhibits testosterone-induced breast cancer cell growth in vitro (IC50 = 0.13 nM).

Licensing Information

(Sold with the permission of Astellas Pharma Inc.)

Technical Data for YM 511

M. Wt 354.2
Formula C16H12BrN5
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 148869-05-0
PubChem ID 177865
InChI Key GGPPBTSXFROGAE-UHFFFAOYSA-N
Smiles BrC(C=C3)=CC=C3CN(N2C=NN=C2)C1=CC=C(C#N)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for YM 511

References are publications that support the biological activity of the product.

Okada et al (1996) Studies on aromatase inhibitors I. Synthesis and biological evaulation of 4-amino-4H-1,2,4-triaole derivatives. Chem.Pharm.Bull. 44 1871 PMID: 8904814

Kudoh et al (1995) The potent and selective inhibiton of estrogen production by non-steroidal aromatase inhibitor, YM511. J.Steroid Biochem.Molec.Biol. 54 265

Kudoh et al (1996) Inhibitory effect of a novel non-steroidal aromatase inhibitor, YM511 on the proliferation of MCF-7 human breast cancer cell. J.Steroid Biochem.Molec.Biol. 58 189

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Citations for YM 511

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Currently there are no citations for YM 511.

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