You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!Submit Review
YM 254890 New
Gα-protein inhibitor. Potently inhibits Gq/11 heterotrimeric G protein signaling. Inhibits ATP/UTP-induced Ca2+ increase in HCAE cells expressing P2Y2 receptor (IC50 = 50 nM); carbachol-induced production of IP1 in CHO cells expressing M1 receptor (IC50 = 95 nM); and ADP-induced Ca2+ increase in platelets, in vitro (IC50 = 2 μM). Also inhibits Gs-induced cAMP elevation and G protein-coupled MAPK/ERK signaling.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 960.09. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.1 mM||10.42 mL||52.08 mL||104.16 mL|
|0.5 mM||2.08 mL||10.42 mL||20.83 mL|
|1 mM||1.04 mL||5.21 mL||10.42 mL|
|5 mM||0.21 mL||1.04 mL||2.08 mL|
References are publications that support the biological activity of the product.
Uemura et al (2006) Biological properties of a specific Gα; q/11 inhibitor, YM-254890, on platelet functions and thrombus formation under high-shear stress. Br.J.Pharmacol. 148 61 PMID: 16520742
Xiong et al (2016) Total synthesis and structure-activity relationship studies of a series of selective G protein inhibitors. Nat.Chem. 8 1035 PMID: 27768111
Xiong et al (2019) Structure-activity relationship studies of the natural product Gq/11 protein inhibitor YM-254890. Chem.Med.Chem. 14 865 PMID: 30790465
Peng et al (2021) Functional evidence for biased inhibition of G protein signaling by YM-254890 in human coronary artery endothelial cells. Eur.J.Pharmacol. 891 173706 PMID: 33152337
If you know of a relevant reference for YM 254890, please let us know.
View Related Products by Product Action
Keywords: YM 254890, YM 254890 supplier, YM254890, heterotrimeric, g, protein, signaling, GPCRs, coupled, receptors, Galpha, Ga, Galfa, G9/11, Gi/o, potent, inhibitors, inhibits, Heterotrimeric, G-protein, GTPases, 7352, Tocris Bioscience
Citations for YM 254890
Citations are publications that use Tocris products.
Currently there are no citations for YM 254890. Do you know of a great paper that uses YM 254890 from Tocris? Please let us know.
Reviews for YM 254890
There are currently no reviews for this product. Be the first to review YM 254890 and earn rewards!
Have you used YM 254890?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.