XY 018

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Description: RORγ antagonist; inhibits AR expression
Chemical Name: N-[2'-Fluoro-4'-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl][1,1'biphenyl]-4-yl]-2-nitrobenzeneacetamide
Purity: ≥98% (HPLC)

Biological Activity for XY 018

XY 018 is a RORγ antagonist (EC50 = 190 nM). Suppresses androgen receptor expression in prostate cancer cell lines. Also inhibits growth of tumors in androgen receptor-positive xenograft models.

Compound Libraries for XY 018

XY 018 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for XY 018

M. Wt 516.36
Formula C23H15F7N2O4
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1873358-87-2
PubChem ID 130248006
Smiles OC(C(F)(F)F)(C(F)(F)F)C1=CC(F)=C(C2=CC=C(C=C2)NC(CC3=C([N+]([O-])=O)C=CC=C3)=O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for XY 018

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 51.64 100
ethanol 51.64 100

Preparing Stock Solutions for XY 018

The following data is based on the product molecular weight 516.36. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.94 mL 9.68 mL 19.37 mL
5 mM 0.39 mL 1.94 mL 3.87 mL
10 mM 0.19 mL 0.97 mL 1.94 mL
50 mM 0.04 mL 0.19 mL 0.39 mL

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References for XY 018

References are publications that support the biological activity of the product.

Wang et al (2016) ROR-γ drives androgen receptor expression and represents a therapeutic target in castration-resistant prostate cancer. Nat.Med. 22 488 PMID: 27019329

Ndagi et al (2018) Re-emergence of an orphan therapeutic target for the treatment of resistant prostate cancer - a through conformational and binding analysis for RORγ protein. J.Biomol.Struct.Dyn. 36 335 PMID: 28027708

If you know of a relevant reference for XY 018, please let us know.

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Citations for XY 018

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