Xaliproden hydrochloride

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Cat.No. 2491 - Xaliproden hydrochloride | C24H22F3N.HCl | CAS No. 90494-79-4
Description: Orally active, high affinity 5-HT1A agonist
Alternative Names: SR 57746A
Chemical Name: 1,2,3,6-Tetrahydro-1-[2-(2-naphthalenyl)ethyl]-4-[3-(trifluoromethyl)phenyl]-pyridine hydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Orally active, full agonist at 5-HT1A receptors. Binds rat 5-HT1A with high affinity (Ki = 2.0 nM) and is > 300-fold selective over other 5-HT receptor subtypes (IC50 > 650 nM). Increases motoneuron survival and promotes effects of NGF on neurite outgrowth in vitro. Displays neurotrophic activity in several neurodegenerative models in vivo. .

Compound Libraries

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Technical Data

M. Wt 417.9
Formula C24H22F3N.HCl
Storage Desiccate at RT
Purity ≥99% (HPLC)
CAS Number 90494-79-4
PubChem ID 128918
InChI Key WVHBEIJGAINUBW-UHFFFAOYSA-N
Smiles Cl.FC(F)(F)C1=CC(=CC=C1)C1=CCN(CCC2=CC=C3C=CC=CC3=C2)CC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 41.79 100
ethanol 8.36 20

Preparing Stock Solutions

The following data is based on the product molecular weight 417.9. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.39 mL 11.96 mL 23.93 mL
5 mM 0.48 mL 2.39 mL 4.79 mL
10 mM 0.24 mL 1.2 mL 2.39 mL
50 mM 0.05 mL 0.24 mL 0.48 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Fournier et al (1993) Protective effects of SR 57746A in central and peripheral models of neurodegenerative disorders in rodents and primates. Neuroscience 55 629 PMID: 8413926

Duong et al (1999) Effect of the nonpeptide neurotrophic compound SR 57746A on the phenotypic survival of purified mouse motoneurons. Br.J.Pharmacol. 128 1385 PMID: 10602316

Bachy et al (1993) Biochemical and electrophysiological properties of SR 57746A, a new, potent 5-HT1A receptor agonist. Fund.Clin.Pharmacol. 7 487 PMID:


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Citations for Xaliproden hydrochloride

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Pathways for Xaliproden hydrochloride

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