WQ 1

Pricing Availability   Qty
Cat.No. 7156 - WQ 1 | C21H23NOS | CAS No. 1204401-49-9
Description: Potent and selective σ1 receptor antagonist; active in vivo
Alternative Names: TC WQ 1, TC Sigma1
Chemical Name: 2,3-Dihydro-2-[1-(phenylmethyl)-4-piperidinyl]-4H-1-benzothiopyran-4-one
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews

Biological Activity

High affinity and selective σ1 receptor antagonist (pKi values are 10.28-10.85, 5.81-6.53 and 5.80 at σ1, σ2 and DAT). Displays σ1/σ2 selectivity ratio of 29512. Selectively blocks binge eating without a general inhibition of food intake in rats.

Technical Data

M. Wt 337.48
Formula C21H23NOS
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1204401-49-9
InChI Key XWMHOCDNGHEUMF-UHFFFAOYSA-N
Smiles O=C(C1=CC=CC=C1S2)CC2C3CCN(CC4=CC=CC=C4)CC3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 16.87 50
ethanol 3.37 10

Preparing Stock Solutions

The following data is based on the product molecular weight 337.48. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 5.93 mL 29.63 mL 59.26 mL
2.5 mM 1.19 mL 5.93 mL 11.85 mL
5 mM 0.59 mL 2.96 mL 5.93 mL
25 mM 0.12 mL 0.59 mL 1.19 mL

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References

References are publications that support the biological activity of the product.

Bello et al (2019) Investigation of the role of chirality in the interaction with σ receptors and effect on binge eating episode of a potent σ 1 antagonist analogue of spipethiane. ACS Chem.Neurosci. 10 3391 PMID: 31298830

Piergentili et al (2010) Novel highly potent and selective sigma 1 receptor antagonists related to spipethiane. J.Med.Chem. 53 1261 PMID: 20067271


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