You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!Submit Review
WB 4101 hydrochloride
α1A-adrenergic selective antagonist. Also available as part of the α1-Adrenoceptor Tocriset™.
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 381.86. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.5 mM||5.24 mL||26.19 mL||52.38 mL|
|2.5 mM||1.05 mL||5.24 mL||10.48 mL|
|5 mM||0.52 mL||2.62 mL||5.24 mL|
|25 mM||0.1 mL||0.52 mL||1.05 mL|
References are publications that support the biological activity of the product.
Green et al (1969) The synthesis and pharmacological properties of a series of 2-substituted aminomethyl-1,4-benzodioxanes. J.Med.Chem. 12 326 PMID: 5791620
Heible et al (1995) α and β-adrenoceptors: from the gene to the clinic. 1. Molecular biology and adrenoceptor subclassification. J.Med.Chem. 38 3415 PMID: 7658428
Morrow and Creese (1986) Characterisation of α1-adrenergic receptor subtypes in rat brain: a re-evaluation of 3H-WB 4101 and 3H-prazosin binding. Mol.Pharmacol. 29 321 PMID: 3010073
If you know of a relevant reference for WB 4101 hydrochloride, please let us know.
View Related Products by Product Action
Keywords: WB 4101 hydrochloride, WB 4101 hydrochloride supplier, α1A-adrenoceptor, alpha1A-adrenoceptor, α1a-adrenergic, alpha1a-adrenergic, antagonists, a1a-Adrenergic, a1a-adrenoceptors, Receptors, WB4101, hydrochloride, Adrenergic, Alpha-1, 0946, Tocris Bioscience
5 Citations for WB 4101 hydrochloride
Citations are publications that use Tocris products. Selected citations for WB 4101 hydrochloride include:
Li et al (2018) Identification of WB4101, an α1-Adrenoceptor Antagonist, as a Sodium Channel Blocker. Mol Pharmacol 94 896 PMID: 29884692
Hott et al (2012) Both α1- and β1-adrenoceptors in the bed nucleus of the stria terminalis are involved in the expression of conditioned contextual fear. Br J Pharmacol 167 207 PMID: 22506532
O-Uchi et al (2008) Interaction of α1-adrenoceptor subtypes with different G proteins induces opposite effects on cardiac L-type Ca2+ channel. J Endocrinol 102 1378 PMID: 18467629
Alves et al (2014) Both α1- and α2-adrenoceptors in the insular cortex are involved in the cardiovascular responses to acute restraint stress in rats. Circ Res 9 e83900 PMID: 24404141
Crestani et al (2008) Both alpha1 and alpha2-adrenoceptors mediate the cardiovascular responses to noradrenaline microinjected into the bed nucleus of the stria terminal of rats. Br J Pharmacol 153 583 PMID: 18037912
Do you know of a great paper that uses WB 4101 hydrochloride from Tocris? Please let us know.
Reviews for WB 4101 hydrochloride
There are currently no reviews for this product. Be the first to review WB 4101 hydrochloride and earn rewards!
Have you used WB 4101 hydrochloride?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.