WB 4101 hydrochloride

Discontinued Product

WB 4101 hydrochloride (Cat. No. 0946) has been withdrawn from sale for commercial reasons.
Description: α1A antagonist
Chemical Name: 2-(2,6-Dimethoxyphenoxyethyl)aminomethyl-1,4-benzodioxane hydrochloride
Purity: ≥99% (HPLC)
Citations (5)
Literature (1)

Biological Activity for WB 4101 hydrochloride

α1A-adrenergic selective antagonist.

Technical Data for WB 4101 hydrochloride

M. Wt 381.86
Formula C19H23NO5.HCl
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 2170-58-3
PubChem ID 11957505

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for WB 4101 hydrochloride

Certificate of Analysis / Product Datasheet
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References for WB 4101 hydrochloride

References are publications that support the biological activity of the product.

Green et al (1969) The synthesis and pharmacological properties of a series of 2-substituted aminomethyl-1,4-benzodioxanes. J.Med.Chem. 12 326 PMID: 5791620

Heible et al (1995) α and β-adrenoceptors: from the gene to the clinic. 1. Molecular biology and adrenoceptor subclassification. J.Med.Chem. 38 3415 PMID: 7658428

Morrow and Creese (1986) Characterisation of α1-adrenergic receptor subtypes in rat brain: a re-evaluation of 3H-WB 4101 and 3H-prazosin binding. Mol.Pharmacol. 29 321 PMID: 3010073

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5 Citations for WB 4101 hydrochloride

Citations are publications that use Tocris products. Selected citations for WB 4101 hydrochloride include:

O-Uchi et al (2008) Interaction of α1-adrenoceptor subtypes with different G proteins induces opposite effects on cardiac L-type Ca2+ channel. J Endocrinol 102 1378 PMID: 18467629

Crestani et al (2008) Both alpha1 and alpha2-adrenoceptors mediate the cardiovascular responses to noradrenaline microinjected into the bed nucleus of the stria terminal of rats. Br J Pharmacol 153 583 PMID: 18037912

Alves et al (2014) Both α1- and α2-adrenoceptors in the insular cortex are involved in the cardiovascular responses to acute restraint stress in rats. Circ Res 9 e83900 PMID: 24404141

Li et al (2018) Identification of WB4101, an α1-Adrenoceptor Antagonist, as a Sodium Channel Blocker. Mol Pharmacol 94 896 PMID: 29884692

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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Depression Poster

Depression Poster

Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.