WB 4101 hydrochloride

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Cat.No. 0946 - WB 4101 hydrochloride | C19H23NO5.HCl | CAS No. 2170-58-3
Description: α1A antagonist
Chemical Name: 2-(2,6-Dimethoxyphenoxyethyl)aminomethyl-1,4-benzodioxane hydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations (5)
Reviews
Literature (4)

Biological Activity

α1A-adrenergic selective antagonist. Also available as part of the α1-Adrenoceptor Tocriset™.

Technical Data

M. Wt 381.86
Formula C19H23NO5.HCl
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 2170-58-3
PubChem ID 11957505
InChI Key KAHMEWANVDFFCQ-UHFFFAOYSA-N
Smiles Cl.COC1=CC=CC(OC)=C1OCCNCC1COC2=C(O1)C=CC=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 19.09 50

Preparing Stock Solutions

The following data is based on the product molecular weight 381.86. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 5.24 mL 26.19 mL 52.38 mL
2.5 mM 1.05 mL 5.24 mL 10.48 mL
5 mM 0.52 mL 2.62 mL 5.24 mL
25 mM 0.1 mL 0.52 mL 1.05 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Green et al (1969) The synthesis and pharmacological properties of a series of 2-substituted aminomethyl-1,4-benzodioxanes. J.Med.Chem. 12 326 PMID: 5791620

Heible et al (1995) α and β-adrenoceptors: from the gene to the clinic. 1. Molecular biology and adrenoceptor subclassification. J.Med.Chem. 38 3415 PMID: 7658428

Morrow and Creese (1986) Characterisation of α1-adrenergic receptor subtypes in rat brain: a re-evaluation of 3H-WB 4101 and 3H-prazosin binding. Mol.Pharmacol. 29 321 PMID: 3010073


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5 Citations for WB 4101 hydrochloride

Citations are publications that use Tocris products. Selected citations for WB 4101 hydrochloride include:

Alves et al (2014) Both α1- and α2-adrenoceptors in the insular cortex are involved in the cardiovascular responses to acute restraint stress in rats. Circ Res 9 e83900 PMID: 24404141

O-Uchi et al (2008) Interaction of α1-adrenoceptor subtypes with different G proteins induces opposite effects on cardiac L-type Ca2+ channel. J Endocrinol 102 1378 PMID: 18467629

Crestani et al (2008) Both alpha1 and alpha2-adrenoceptors mediate the cardiovascular responses to noradrenaline microinjected into the bed nucleus of the stria terminal of rats. Br J Pharmacol 153 583 PMID: 18037912

Li et al (2018) Identification of WB4101, an α1-Adrenoceptor Antagonist, as a Sodium Channel Blocker. Mol Pharmacol 94 896 PMID: 29884692

Hott et al (2012) Both α1- and β1-adrenoceptors in the bed nucleus of the stria terminalis are involved in the expression of conditioned contextual fear. Br J Pharmacol 167 207 PMID: 22506532


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Literature in this Area

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