WAY 629 hydrochloride

Pricing Availability Delivery Time Qty
Cat.No. 2173 - WAY 629 hydrochloride | C15H18N2.HCl | CAS No. 57756-44-2
Description: Selective 5-HT2C agonist
Chemical Name: 1,2,3,4,8,9,10,11-Octahydro[1,4]diazepino[6,7,1-jk]carbazole hydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Selective 5-HT2C agonist. Ki values are 56, 2350, 1575 and 815 nM for human recombinant 5-HT2C, 5-HT2A, 5-HT6 and 5-HT7 receptors respectively. Stimulates intracellular Ca2+ mobilization in CHO cells expressing human 5-HT2C receptors (EC50 = 72 nM). Reduces food intake in rats.

Technical Data

M. Wt 262.78
Formula C15H18N2.HCl
Storage Desiccate at +4°C
Purity ≥98% (HPLC)
CAS Number 57756-44-2
PubChem ID 12259556
InChI Key PZXUJERSOFOWES-UHFFFAOYSA-N
Smiles Cl.C1CCC2=C(C1)N1CCNCC3=C1C2=CC=C3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 26.28 100

Preparing Stock Solutions

The following data is based on the product molecular weight 262.78. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.81 mL 19.03 mL 38.05 mL
5 mM 0.76 mL 3.81 mL 7.61 mL
10 mM 0.38 mL 1.9 mL 3.81 mL
50 mM 0.08 mL 0.38 mL 0.76 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Sabb et al (2004) Cycloalkyl[b][1,4]benzodiazepinoindoles are agonists at the human 5-HT2C receptor. Bioorg.Med.Chem.Lett. 14 2603 PMID: 15109661

Dunlop et al (2004) Identification of cycloalkyl[b][1,4]benzodiazepinoindoles as novel 5-HT2C receptor agonists. Fund.Clin.Pharmacol. 18 145 PMID:


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