WAY 629 hydrochloride

Pricing Availability   Qty
Cat.No. 2173 - WAY 629 hydrochloride | C15H18N2.HCl | CAS No. 57756-44-2
Description: Selective 5-HT2C agonist
Chemical Name: 1,2,3,4,8,9,10,11-Octahydro[1,4]diazepino[6,7,1-jk]carbazole hydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (4)

Biological Activity

Selective 5-HT2C agonist. Ki values are 56, 2350, 1575 and 815 nM for human recombinant 5-HT2C, 5-HT2A, 5-HT6 and 5-HT7 receptors respectively. Stimulates intracellular Ca2+ mobilization in CHO cells expressing human 5-HT2C receptors (EC50 = 72 nM). Reduces food intake in rats.

Technical Data

M. Wt 262.78
Formula C15H18N2.HCl
Storage Desiccate at +4°C
Purity ≥98% (HPLC)
CAS Number 57756-44-2
PubChem ID 12259556
InChI Key PZXUJERSOFOWES-UHFFFAOYSA-N
Smiles Cl.C1CCC2=C(C1)N1CCNCC3=C1C2=CC=C3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 26.28 100

Preparing Stock Solutions

The following data is based on the product molecular weight 262.78. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.81 mL 19.03 mL 38.05 mL
5 mM 0.76 mL 3.81 mL 7.61 mL
10 mM 0.38 mL 1.9 mL 3.81 mL
50 mM 0.08 mL 0.38 mL 0.76 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

References

References are publications that support the biological activity of the product.

Sabb et al (2004) Cycloalkyl[b][1,4]benzodiazepinoindoles are agonists at the human 5-HT2C receptor. Bioorg.Med.Chem.Lett. 14 2603 PMID: 15109661

Dunlop et al (2004) Identification of cycloalkyl[b][1,4]benzodiazepinoindoles as novel 5-HT2C receptor agonists. Fund.Clin.Pharmacol. 18 145


If you know of a relevant reference for WAY 629 hydrochloride, please let us know.

View Related Products by Target

View Related Products by Product Action

View all 5-HT2C Receptor Agonists

Keywords: WAY 629 hydrochloride, WAY 629 hydrochloride supplier, Selective, 5-HT2C, agonists, Serotonin, Receptors, WAY629, hydrochloride, 2173, Tocris Bioscience

Citations for WAY 629 hydrochloride

Citations are publications that use Tocris products.

Currently there are no citations for WAY 629 hydrochloride. Do you know of a great paper that uses WAY 629 hydrochloride from Tocris? Please let us know.

Reviews for WAY 629 hydrochloride

There are currently no reviews for this product. Be the first to review WAY 629 hydrochloride and earn rewards!

Have you used WAY 629 hydrochloride?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


GPCR

GPCR Product Listing

A collection of over 450 products for G protein-coupled receptors, the listing includes research tools for the study of:

  • Rhodopsin-like Receptors
  • Glutamate Receptors
  • Frizzled Receptors
  • GPCR Signaling
5-HT Receptors

5-HT Receptors Scientific Review

Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.

Depression

Depression Poster

Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.

Parkinson's

Parkinson's Poster

Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.