WAY 252623

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Description: Potent LXR agonist
Chemical Name: 2-[(2-Chloro-4-fluorophenyl)methyl]-3-(4-fluorophenyl)-7-(trifluoromethyl)-2H-indazole
Purity: ≥98% (HPLC)

Biological Activity for WAY 252623

WAY 252623 is a potent LXR agonist (IC50 values are 24 and 179 nM for LXRβ and LXRα, respectively). Reduces total serum cholesterol and LDL cholesterol, and inhibits lesion growth in models of atherosclerosis. Increases ABCA1 and ABCG1 mRNA levels in rat peripheral blood cells. Orally bioavailable.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Compound Libraries for WAY 252623

WAY 252623 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for WAY 252623

M. Wt 422.78
Formula C21H12ClF5N2
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 875787-07-8
PubChem ID 16734800
Smiles ClC1=CC(F)=CC=C1CN2N=C3C(C(F)(F)F)=CC=CC3=C2C4=CC=C(F)C=C4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for WAY 252623

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 42.28 100
ethanol 42.28 100

Preparing Stock Solutions for WAY 252623

The following data is based on the product molecular weight 422.78. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.37 mL 11.83 mL 23.65 mL
5 mM 0.47 mL 2.37 mL 4.73 mL
10 mM 0.24 mL 1.18 mL 2.37 mL
50 mM 0.05 mL 0.24 mL 0.47 mL

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References for WAY 252623

References are publications that support the biological activity of the product.

DiBlasio-Smith et al (2008) Discovery and implementation of transcriptional biomarkers of synthetic LXR agonists in peripheral blood cells. J.Transl.Med. 6 PMID: 18925943

Quinet et al (2009) LXR ligand lowers LDL cholesterol in primates, is lipid neutral in hamster, and reduces atherosclerosis in mouse. J.Lipid Res. 50 2358 PMID: 19318684

If you know of a relevant reference for WAY 252623, please let us know.

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Keywords: WAY 252623, WAY 252623 supplier, WAY252623, LXR, liver, X, receptor, alpha, beta, LXRa, LXRb, β, α, potent, agonists, agonism, orally, bioavailable, LXR-like, Receptors, 5951, Tocris Bioscience

Citations for WAY 252623

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