WAY 252623

Pricing Availability Delivery Time Qty
Cat.No. 5951 - WAY 252623 | C21H12ClF5N2 | CAS No. 875787-07-8
Description: Potent LXR agonist
Chemical Name: 2-[(2-Chloro-4-fluorophenyl)methyl]-3-(4-fluorophenyl)-7-(trifluoromethyl)-2H-indazole
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Potent LXR agonist (IC50 values are 24 and 179 nM for LXRβ and LXRα, respectively). Reduces total serum cholesterol and LDL cholesterol, and inhibits lesion growth in models of atherosclerosis. Increases ABCA1 and ABCG1 mRNA levels in rat peripheral blood cells. Orally bioavailable.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Technical Data

M. Wt 422.78
Formula C21H12ClF5N2
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 875787-07-8
PubChem ID 16734800
InChI Key KYWWJENKIMRJBI-UHFFFAOYSA-N
Smiles ClC1=CC(F)=CC=C1CN2N=C3C(C(F)(F)F)=CC=CC3=C2C4=CC=C(F)C=C4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 42.28 100
ethanol 42.28 100

Preparing Stock Solutions

The following data is based on the product molecular weight 422.78. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.37 mL 11.83 mL 23.65 mL
5 mM 0.47 mL 2.37 mL 4.73 mL
10 mM 0.24 mL 1.18 mL 2.37 mL
50 mM 0.05 mL 0.24 mL 0.47 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

DiBlasio-Smith et al (2008) Discovery and implementation of transcriptional biomarkers of synthetic LXR agonists in peripheral blood cells. J.Transl.Med. 6 PMID: 18925943

Quinet et al (2009) LXR ligand lowers LDL cholesterol in primates, is lipid neutral in hamster, and reduces atherosclerosis in mouse. J.Lipid Res. 50 2358 PMID: 19318684


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Keywords: LXR liver X receptor alpha beta LXRa LXRb β α potent agonists agonism orally bioavailable LXR-like Receptors

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