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Submit ReviewVUF 5681 dihydrobromide
Discontinued Product
2493 has been discontinued.
View all Histamine H<sub>3</sub> Receptors products.
Description: Potent H3 receptor silent antagonist
Chemical Name: 4-[3-(1H-Imidazol-4-yl)propyl]piperidine dihydrobromide
Purity: ≥98% (HPLC)
Biological Activity for VUF 5681 dihydrobromide
VUF 5681 dihydrobromide is a potent histamine H3 receptor silent antagonist (pKi = 8.35).
Technical Data for VUF 5681 dihydrobromide
| M. Wt | 355.11 |
| Formula | C11H19N3.2HBr |
| Storage | Desiccate at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 639089-06-8 |
| PubChem ID | 53440140 |
| InChI Key | YFFVIGXPKWSZHW-UHFFFAOYSA-N |
| Smiles | Br.Br.C(CC1CCNCC1)CC1=CNC=N1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for VUF 5681 dihydrobromide
References for VUF 5681 dihydrobromide
References are publications that support the biological activity of the product.
Kitbunnadaj et al (2004) Identification of 4-(1H-imidazol-4(5)-ylmethyl)pyridine (immethridine) as a novel, potent, and highly selective histamine H3 receptor agonist. J.Med.Chem. 47 2414 PMID: 15115383
Leurs et al (2005) The histamine H3 receptor: from gene cloning to H3 receptor drugs. Nat.Rev.Drug Discov. 4 107 PMID: 15665857
Moreno-Delgado et al (2006) Constitutive activity of H3 autoreceptors modulates histamine synthesis in rat brain through the cAMP/PKA pathway. Neuropharmacology 51 517 PMID: 16769092
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Keywords: VUF 5681 dihydrobromide, VUF 5681 dihydrobromide supplier, Potent, H3, receptor, silent, antagonists, Receptors, Histamine, histaminergic, VUF5681, dihydrobromide, 2493, Tocris Bioscience
Citations for VUF 5681 dihydrobromide
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Currently there are no citations for VUF 5681 dihydrobromide.
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Histamine Receptors Scientific Review
Written by Iwan de Esch and Rob Leurs, this review provides a synopsis of the different histamine receptor subtypes and the ligands that act upon them; compounds available from Tocris are listed.
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