VUF 5681 dihydrobromide

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Cat.No. 2493 - VUF 5681 dihydrobromide | C11H19N3.2HBr | CAS No. 639089-06-8
Description: Potent H3 receptor silent antagonist
Chemical Name: 4-[3-(1H-Imidazol-4-yl)propyl]piperidine dihydrobromide
Purity: ≥98% (HPLC)
Literature (4)

Biological Activity for VUF 5681 dihydrobromide

VUF 5681 dihydrobromide is a potent histamine H3 receptor silent antagonist (pKi = 8.35).

Technical Data for VUF 5681 dihydrobromide

M. Wt 355.11
Formula C11H19N3.2HBr
Storage Desiccate at RT
Purity ≥98% (HPLC)
CAS Number 639089-06-8
PubChem ID 53440140
Smiles Br.Br.C(CC1CCNCC1)CC1=CNC=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for VUF 5681 dihydrobromide

Solvent Max Conc. mg/mL Max Conc. mM
water 35.51 100
DMSO 35.51 100

Preparing Stock Solutions for VUF 5681 dihydrobromide

The following data is based on the product molecular weight 355.11. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.82 mL 14.08 mL 28.16 mL
5 mM 0.56 mL 2.82 mL 5.63 mL
10 mM 0.28 mL 1.41 mL 2.82 mL
50 mM 0.06 mL 0.28 mL 0.56 mL

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Product Datasheets for VUF 5681 dihydrobromide

References for VUF 5681 dihydrobromide

References are publications that support the biological activity of the product.

Kitbunnadaj et al (2004) Identification of 4-(1H-imidazol-4(5)-ylmethyl)pyridine (immethridine) as a novel, potent, and highly selective histamine H3 receptor agonist. J.Med.Chem. 47 2414 PMID: 15115383

Leurs et al (2005) The histamine H3 receptor: from gene cloning to H3 receptor drugs. Nat.Rev.Drug Discov. 4 107 PMID: 15665857

Moreno-Delgado et al (2006) Constitutive activity of H3 autoreceptors modulates histamine synthesis in rat brain through the cAMP/PKA pathway. Neuropharmacology 51 517 PMID: 16769092

If you know of a relevant reference for VUF 5681 dihydrobromide, please let us know.

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Citations for VUF 5681 dihydrobromide

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