VUF 11207 fumarate

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Cat.No. 4780 - VUF 11207 fumarate | C27H35FN2O4.C4H4O4 | CAS No. 1785665-61-3
Description: Potent ACKR3 (CXCR7) agonist
Chemical Name: N-[(2E)-3-(2-Fluorophenyl)-2-methyl-2-propen-1-yl]-3,4,5-trimethoxy-N-[2-(1-methyl-2-pyrrolidinyl)ethyl]benzamide fumarate
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (4)

Biological Activity for VUF 11207 fumarate

VUF 11207 fumarate is a potent ACKR3 (CXCR7) chemokine receptor agonist (EC50 = 1.6 nM). Induces recruitment of β-arrestin to CXCR7 in HEK293-CXCR7 cells.

Compound Libraries for VUF 11207 fumarate

VUF 11207 fumarate is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for VUF 11207 fumarate

M. Wt 586.65
Formula C27H35FN2O4.C4H4O4
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1785665-61-3
PubChem ID 90488970
InChI Key MTPOECCHJLVVGO-FDULSSLPSA-N
Smiles C\C(CN(CCC2N(C)CCC2)C(C3=CC(OC)=C(OC)C(OC)=C3)=O)=C/C1=C(F)C=CC=C1.OC(/C=C/C(O)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for VUF 11207 fumarate

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 58.66 100
DMSO 58.66 100

Preparing Stock Solutions for VUF 11207 fumarate

The following data is based on the product molecular weight 586.65. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.7 mL 8.52 mL 17.05 mL
5 mM 0.34 mL 1.7 mL 3.41 mL
10 mM 0.17 mL 0.85 mL 1.7 mL
50 mM 0.03 mL 0.17 mL 0.34 mL

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Product Datasheets for VUF 11207 fumarate

References for VUF 11207 fumarate

References are publications that support the biological activity of the product.

Wijtmans et al (2012) Synthesis, modeling and functional activity of substituted styrene-amides as small-molecule CXCR7 agonists. Eur.J.Med.Chem. 51 184 PMID: 22424612


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Keywords: VUF 11207 fumarate, VUF 11207 fumarate supplier, VUF11207, fumarate, CXCR7, chemokine, receptors, potent, agonist, Chemokine, CXC, Receptors, 4780, Tocris Bioscience

Citations for VUF 11207 fumarate

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Reviews for VUF 11207 fumarate

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