VUF 11207 fumarate

Pricing Availability Delivery Time Qty
Cat.No. 4780 - VUF 11207 fumarate | C27H35FN2O4.C4H4O4
Description: Potent ACKR3 (CXCR7) agonist
Chemical Name: N-[(2E)-3-(2-Fluorophenyl)-2-methyl-2-propen-1-yl]-3,4,5-trimethoxy-N-[2-(1-methyl-2-pyrrolidinyl)ethyl]benzamide fumarate
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Potent ACKR3 (CXCR7) chemokine receptor agonist (EC50 = 1.6 nM). Induces recruitment of β-arrestin to CXCR7 in HEK293-CXCR7 cells.

Compound Libraries

VUF 11207 fumarate is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 586.65
Formula C27H35FN2O4.C4H4O4
Storage Store at -20°C
Purity ≥98% (HPLC)
PubChem ID 90488970
InChI Key MTPOECCHJLVVGO-FDULSSLPSA-N
Smiles C\C(CN(CCC2N(C)CCC2)C(C3=CC(OC)=C(OC)C(OC)=C3)=O)=C/C1=C(F)C=CC=C1.OC(/C=C/C(O)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 58.66 100
water 58.66 100

Preparing Stock Solutions

The following data is based on the product molecular weight 586.65. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.7 mL 8.52 mL 17.05 mL
5 mM 0.34 mL 1.7 mL 3.41 mL
10 mM 0.17 mL 0.85 mL 1.7 mL
50 mM 0.03 mL 0.17 mL 0.34 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Wijtmans et al (2012) Synthesis, modeling and functional activity of substituted styrene-amides as small-molecule CXCR7 agonists. Eur.J.Med.Chem. 51 184 PMID: 22424612


If you know of a relevant reference for VUF 11207 fumarate, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Chemokine CXC Receptor Agonists

Keywords: VUF11207 fumarate CXCR7 chemokine receptors potent agonist Chemokine CXC Receptors

Citations for VUF 11207 fumarate

Citations are publications that use Tocris products.

Currently there are no citations for VUF 11207 fumarate. Do you know of a great paper that uses VUF 11207 fumarate from Tocris? If so please let us know.

Commented out for usability testing

Reviews

TODO: Add Reviews

Literature in this Area

Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
GPCR

GPCR Product Listing

A collection of over 450 products for G protein-coupled receptors, the listing includes research tools for the study of:

  • Rhodopsin-like Receptors
  • Secretin-like Receptors
  • Glutamate Receptors
  • Frizzled Receptors
  • GPCR Signaling
Immunology

Immunology Product Listing

A collection of over 190 products for immunology research, the guide includes research tools for the study of:

  • Chemokine and Cytokine Signaling
  • Chemotaxis
  • Complement System
  • Immune Cell Signaling
  • Inflammation

Pathways for VUF 11207 fumarate

Protocols

TODO: Add Protocols