VUF 11207 fumarate

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Cat.No. 4780 - VUF 11207 fumarate | C27H35FN2O4.C4H4O4 | CAS No. 1785665-61-3
Description: Potent ACKR3 (CXCR7) agonist
Chemical Name: N-[(2E)-3-(2-Fluorophenyl)-2-methyl-2-propen-1-yl]-3,4,5-trimethoxy-N-[2-(1-methyl-2-pyrrolidinyl)ethyl]benzamide fumarate
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Potent ACKR3 (CXCR7) chemokine receptor agonist (EC50 = 1.6 nM). Induces recruitment of β-arrestin to CXCR7 in HEK293-CXCR7 cells.

Compound Libraries

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Technical Data

M. Wt 586.65
Formula C27H35FN2O4.C4H4O4
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1785665-61-3
PubChem ID 90488970
InChI Key MTPOECCHJLVVGO-FDULSSLPSA-N
Smiles C\C(CN(CCC2N(C)CCC2)C(C3=CC(OC)=C(OC)C(OC)=C3)=O)=C/C1=C(F)C=CC=C1.OC(/C=C/C(O)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 58.66 100
DMSO 58.66 100

Preparing Stock Solutions

The following data is based on the product molecular weight 586.65. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.7 mL 8.52 mL 17.05 mL
5 mM 0.34 mL 1.7 mL 3.41 mL
10 mM 0.17 mL 0.85 mL 1.7 mL
50 mM 0.03 mL 0.17 mL 0.34 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the biological activity of the product.

Wijtmans et al (2012) Synthesis, modeling and functional activity of substituted styrene-amides as small-molecule CXCR7 agonists. Eur.J.Med.Chem. 51 184 PMID: 22424612


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Citations for VUF 11207 fumarate

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Literature in this Area

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