VU 152100

Pricing Availability   Qty
Description: Positive allosteric modulator of M4 receptors
Alternative Names: ML 108
Chemical Name: 3-Amino-N-(4-methoxybenzyl)-4,6-dimethylthieno[2,3-b]pyridine carboxamide
Purity: ≥98% (HPLC)
Literature (1)

Biological Activity for VU 152100

VU 152100 is a selective positive allosteric modulator of M4 muscarinic acetylcholine receptors (mAChRs) (EC50 = 380 nM). Induces 21-fold shift in ACh potency at M4 receptor. Displays no activity at other mAChR subtypes.

Compound Libraries for VU 152100

VU 152100 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for VU 152100

M. Wt 341.43
Formula C18H19N3O2S
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 409351-28-6
PubChem ID 864492
Smiles CC1=C2C(SC(C(NCC3=CC=C(OC)C=C3)=O)=C2N)=NC(C)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for VU 152100

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 17.07 50

Preparing Stock Solutions for VU 152100

The following data is based on the product molecular weight 341.43. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 5.86 mL 29.29 mL 58.58 mL
2.5 mM 1.17 mL 5.86 mL 11.72 mL
5 mM 0.59 mL 2.93 mL 5.86 mL
25 mM 0.12 mL 0.59 mL 1.17 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Product Datasheets for VU 152100

Certificate of Analysis / Product Datasheet
Select another batch:

References for VU 152100

References are publications that support the biological activity of the product.

Brady et al (2008) Centrally active allosteric potentiators of the M4 muscarinic acetylcholine receptor reverse amphetamine-induced hyperlocomotor activity in rats. J.Pharmacol.Exp.Ther. 327 941 PMID: 18772318

If you know of a relevant reference for VU 152100, please let us know.

View Related Products by Target

View Related Products by Product Action

View all M4 Receptor Modulators

Keywords: VU 152100, VU 152100 supplier, muscarinic, receptors, mAChR, M4, acetylcholine, ACh, selective, positive, allosteric, modulators, VU152100, PAM, ML, 108, ML_108, ML108, Receptors, 3383, Tocris Bioscience

Citations for VU 152100

Citations are publications that use Tocris products.

Currently there are no citations for VU 152100. Do you know of a great paper that uses VU 152100 from Tocris? Please let us know.

Reviews for VU 152100

There are currently no reviews for this product. Be the first to review VU 152100 and earn rewards!

Have you used VU 152100?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Alzheimer's Disease Poster

Alzheimer's Disease Poster

Alzheimer's disease (AD) is a debilitating and progressive neurodegenerative disease and the most common cause of dementia, affecting approximately 30% of individuals aged over 85 years. This poster summarizes the cellular and molecular mechanisms of AD.