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Biological Activity for VU 152100
VU 152100 is a selective positive allosteric modulator of M4 muscarinic acetylcholine receptors (mAChRs) (EC50 = 380 nM). Induces 21-fold shift in ACh potency at M4 receptor. Displays no activity at other mAChR subtypes.
Compound Libraries for VU 152100
Technical Data for VU 152100
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for VU 152100
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for VU 152100
The following data is based on the product molecular weight 341.43. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.5 mM||5.86 mL||29.29 mL||58.58 mL|
|2.5 mM||1.17 mL||5.86 mL||11.72 mL|
|5 mM||0.59 mL||2.93 mL||5.86 mL|
|25 mM||0.12 mL||0.59 mL||1.17 mL|
References for VU 152100
References are publications that support the biological activity of the product.
Brady et al (2008) Centrally active allosteric potentiators of the M4 muscarinic acetylcholine receptor reverse amphetamine-induced hyperlocomotor activity in rats. J.Pharmacol.Exp.Ther. 327 941 PMID: 18772318
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Keywords: VU 152100, VU 152100 supplier, muscarinic, receptors, mAChR, M4, acetylcholine, ACh, selective, positive, allosteric, modulators, VU152100, PAM, ML, 108, ML_108, ML108, Receptors, 3383, Tocris Bioscience
Citations for VU 152100
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Literature in this Area
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Learning & Memory Poster
Recognition memory enables us to make judgements about whether or not we have encountered a particular stimulus before. This poster outlines the cellular mechanisms underlying recognition memory and its links to long-term depression, as well as the use of pharmacological intervention to assess the role of neurotransmitters in recognition memory.