VU 0365114

Pricing Availability   Qty
Description: Positive allosteric modulator of M5 receptors
Chemical Name: 1-[(1,1'-Biphenyl)-4-ylmethyl]-5-(trifluoromethoxy)-1H-indole-2,3-dione
Purity: ≥98% (HPLC)
Literature (2)

Biological Activity for VU 0365114

VU 0365114 is a selective positive allosteric modulator of M5 (EC50 values are 2.7 μM for human M5, and >30 μM for M1, M2, M3 and M4 receptors).

Technical Data for VU 0365114

M. Wt 397.35
Formula C22H14F3NO3
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 1208222-39-2
PubChem ID 45281794
Smiles O=C(C1=CC(OC(F)(F)F)=CC=C1N2CC3=CC=C(C4=CC=CC=C4)C=C3)C2=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for VU 0365114

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 39.73 100
ethanol 3.97 10

Preparing Stock Solutions for VU 0365114

The following data is based on the product molecular weight 397.35. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.52 mL 12.58 mL 25.17 mL
5 mM 0.5 mL 2.52 mL 5.03 mL
10 mM 0.25 mL 1.26 mL 2.52 mL
50 mM 0.05 mL 0.25 mL 0.5 mL

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References for VU 0365114

References are publications that support the biological activity of the product.

Bridges et al (2010) Chemical lead optimization of a pan Gq mAChR M1, M3, M5 positive allosteric modulator (PAM) lead. Part I: development of the first highly selective M5 PAM. Bioorg.Med.Chem.Lett. 20 558 PMID: 20004578

Bridges et al (2010) Heterobiaryl and heterobiaryl ether derived M5 positive allosteric modulators. Bioorg.Med.Chem.Lett. 20 5617 PMID: 20801651

If you know of a relevant reference for VU 0365114, please let us know.

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Citations for VU 0365114

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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