VU 0365114

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Cat.No. 4404 - VU 0365114 | C22H14F3NO3 | CAS No. 1208222-39-2
Description: Positive allosteric modulator of M5 receptors
Chemical Name: 1-[(1,1'-Biphenyl)-4-ylmethyl]-5-(trifluoromethoxy)-1H-indole-2,3-dione
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Selective positive allosteric modulator of M5 (EC50 values are 2.7 μM for human M5, and >30 μM for M1, M2, M3 and M4 receptors).

Technical Data

M. Wt 397.35
Formula C22H14F3NO3
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 1208222-39-2
PubChem ID 45281794
InChI Key SPBGRXOPAXZSER-UHFFFAOYSA-N
Smiles O=C(C1=CC(OC(F)(F)F)=CC=C1N2CC3=CC=C(C4=CC=CC=C4)C=C3)C2=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 39.73 100
ethanol 3.97 10

Preparing Stock Solutions

The following data is based on the product molecular weight 397.35. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.52 mL 12.58 mL 25.17 mL
5 mM 0.5 mL 2.52 mL 5.03 mL
10 mM 0.25 mL 1.26 mL 2.52 mL
50 mM 0.05 mL 0.25 mL 0.5 mL

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Product Datasheets

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References

References are publications that support the products' biological activity.

Bridges et al (2010) Chemical lead optimization of a pan Gq mAChR M1, M3, M5 positive allosteric modulator (PAM) lead. Part I: development of the first highly selective M5 PAM. Bioorg.Med.Chem.Lett. 20 558 PMID: 20004578

Bridges et al (2010) Heterobiaryl and heterobiaryl ether derived M5 positive allosteric modulators. Bioorg.Med.Chem.Lett. 20 5617 PMID: 20801651


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