VU 0364739 hydrochloride

Pricing Availability   Qty
Description: Potent and selective PLD2 inhibitor
Chemical Name: N-[2-[1-(3-Fluorophenyl)-4-oxo-1,3,8-triazaspiro[4.5]dec-8-yl]ethyl]-2-naphthalenecarboxamide
Purity: ≥98% (HPLC)
Datasheet
Citations (10)
Reviews

Biological Activity for VU 0364739 hydrochloride

VU 0364739 hydrochloride is a potent and selective phospholipase D2 (PLD2) inhibitor (IC50 = 20 nM); displays 75-fold selectivity against PLD1 (IC50 = 1500 nM).

Compound Libraries for VU 0364739 hydrochloride

VU 0364739 hydrochloride is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for VU 0364739 hydrochloride

M. Wt 482.98
Formula C26H27FN4O2.HCl
Storage Desiccate at RT
Purity ≥98% (HPLC)
CAS Number 1244640-48-9
PubChem ID 46939225
InChI Key RYLAMDMOILNBKN-UHFFFAOYSA-N
Smiles O=C(NCCN3CCC(C(NCN4C5=CC(F)=CC=C5)=O)4CC3)C2=CC1=CC=CC=C1C=C2.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for VU 0364739 hydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 48.3 100

Preparing Stock Solutions for VU 0364739 hydrochloride

The following data is based on the product molecular weight 482.98. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.07 mL 10.35 mL 20.7 mL
5 mM 0.41 mL 2.07 mL 4.14 mL
10 mM 0.21 mL 1.04 mL 2.07 mL
50 mM 0.04 mL 0.21 mL 0.41 mL

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Product Datasheets for VU 0364739 hydrochloride

Certificate of Analysis / Product Datasheet
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References for VU 0364739 hydrochloride

References are publications that support the biological activity of the product.

Lavieri et al (2010) Design, synthesis, and biological evaluation of halogenated N-(2-(4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-8-yl)-ethyl)benzamides: discovery of an isoform-selective small molecule phospholipase D2 inhibitor. J.Med.Chem. 53 6709


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10 Citations for VU 0364739 hydrochloride

Citations are publications that use Tocris products. Selected citations for VU 0364739 hydrochloride include:

Jiang et al (2016) Phosphatidic Acid Produced by RalA-activated PLD2 Stimulates Caveolae-mediated Endocytosis and Trafficking in Endothelial Cells. J Biol Chem. 291 20729 PMID: 27510034

Tove Irene et al (2021) Diacylglycerol kinase and phospholipase D inhibitors alter the cellular lipidome and endosomal sorting towards the Golgi apparatus. Cell Mol Life Sci 78 985-1009 PMID: 32447426

Basiouni et al (2013) The influence of polyunsaturated fatty acids on the phospholipase D isoforms trafficking and activity in mast cells. Autophagy 14 9005 PMID: 23698760

Bich et al (2018) Physiological function of phospholipase D2 in anti-tumor immunity: regulation of CD8+ T lymphocyte proliferation. Sci Rep 8 6283 PMID: 29674728


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