VU 0364739 hydrochloride

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Cat.No. 4171 - VU 0364739 hydrochloride | C26H27FN4O2.HCl | CAS No. 1244640-48-9
Description: Potent and selective PLD2 inhibitor
Chemical Name: N-[2-[1-(3-Fluorophenyl)-4-oxo-1,3,8-triazaspiro[4.5]dec-8-yl]ethyl]-2-naphthalenecarboxamide
Purity: ≥98% (HPLC)
Datasheet
Citations (2)
Literature

Biological Activity

Potent and selective phospholipase D2 (PLD2) inhibitor (IC50 = 20 nM); displays 75-fold selectivity against PLD1 (IC50 = 1500 nM).

Compound Libraries

VU 0364739 hydrochloride is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 482.98
Formula C26H27FN4O2.HCl
Storage Desiccate at RT
Purity ≥98% (HPLC)
CAS Number 1244640-48-9
PubChem ID 46939225
InChI Key RYLAMDMOILNBKN-UHFFFAOYSA-N
Smiles O=C(NCCN3CCC(C(NCN4C5=CC(F)=CC=C5)=O)4CC3)C2=CC1=CC=CC=C1C=C2.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 48.3 100

Preparing Stock Solutions

The following data is based on the product molecular weight 482.98. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.07 mL 10.35 mL 20.7 mL
5 mM 0.41 mL 2.07 mL 4.14 mL
10 mM 0.21 mL 1.04 mL 2.07 mL
50 mM 0.04 mL 0.21 mL 0.41 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Lavieri et al (2010) Design, synthesis, and biological evaluation of halogenated N-(2-(4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-8-yl)-ethyl)benzamides: discovery of an isoform-selective small molecule phospholipase D2 inhibitor. J.Med.Chem. 53 6709 PMID:


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2 Citations for VU 0364739 hydrochloride

Citations are publications that use Tocris products. Selected citations for VU 0364739 hydrochloride include:

Jiang et al (2016) Phosphatidic Acid Produced by RalA-activated PLD2 Stimulates Caveolae-mediated Endocytosis and Trafficking in Endothelial Cells. J Biol Chem. 291 20729 PMID: 27510034

Basiouni et al (2013) The influence of polyunsaturated fatty acids on the phospholipase D isoforms trafficking and activity in mast cells. Autophagy 14 9005 PMID: 23698760


Do you know of a great paper that uses VU 0364739 hydrochloride from Tocris? If so please let us know.

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