VU 0364739 hydrochloride

Pricing Availability   Qty
Cat.No. 4171 - VU 0364739 hydrochloride | C26H27FN4O2.HCl | CAS No. 1244640-48-9
Description: Potent and selective PLD2 inhibitor
Chemical Name: N-[2-[1-(3-Fluorophenyl)-4-oxo-1,3,8-triazaspiro[4.5]dec-8-yl]ethyl]-2-naphthalenecarboxamide
Purity: ≥98% (HPLC)
Datasheet
Citations (6)
Reviews
Literature

Biological Activity

Potent and selective phospholipase D2 (PLD2) inhibitor (IC50 = 20 nM); displays 75-fold selectivity against PLD1 (IC50 = 1500 nM).

Compound Libraries

VU 0364739 hydrochloride is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 482.98
Formula C26H27FN4O2.HCl
Storage Desiccate at RT
Purity ≥98% (HPLC)
CAS Number 1244640-48-9
PubChem ID 46939225
InChI Key RYLAMDMOILNBKN-UHFFFAOYSA-N
Smiles O=C(NCCN3CCC(C(NCN4C5=CC(F)=CC=C5)=O)4CC3)C2=CC1=CC=CC=C1C=C2.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 48.3 100

Preparing Stock Solutions

The following data is based on the product molecular weight 482.98. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.07 mL 10.35 mL 20.7 mL
5 mM 0.41 mL 2.07 mL 4.14 mL
10 mM 0.21 mL 1.04 mL 2.07 mL
50 mM 0.04 mL 0.21 mL 0.41 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets

Certificate of Analysis / Product Datasheet
Select another batch:

References

References are publications that support the biological activity of the product.

Lavieri et al (2010) Design, synthesis, and biological evaluation of halogenated N-(2-(4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-8-yl)-ethyl)benzamides: discovery of an isoform-selective small molecule phospholipase D2 inhibitor. J.Med.Chem. 53 6709


If you know of a relevant reference for VU 0364739 hydrochloride, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Phospholipase Inhibitors

Keywords: VU 0364739 hydrochloride, VU 0364739 hydrochloride supplier, VU0364739, hydrochloride, phospholipases, d1, d2, potent, selective, inhibitors, inhibits, pld2, Phospholipases, 4171, Tocris Bioscience

6 Citations for VU 0364739 hydrochloride

Citations are publications that use Tocris products. Selected citations for VU 0364739 hydrochloride include:

Jiang et al (2016) Phosphatidic Acid Produced by RalA-activated PLD2 Stimulates Caveolae-mediated Endocytosis and Trafficking in Endothelial Cells. J Biol Chem. 291 20729 PMID: 27510034

Martínez-Martínez et al (2014) Phospholipase D2 is involved in the formation of Golgi tubules and ArfGAP1 recruitment. PLoS One 9 e111685 PMID: 25354038

Basiouni et al (2013) The influence of polyunsaturated fatty acids on the phospholipase D isoforms trafficking and activity in mast cells. Autophagy 14 9005 PMID: 23698760

Krishnan et al (2018) Elevated phospholipase D isoform 1 in Alzheimer's disease patients' hippocampus: Relevance to synaptic dysfunction and memory deficits. Alzheimer Dement (N Y) 4 89 PMID: 29560412

Liu et al (2017) PLD2 regulates microtubule stability and spindle migration in mouse oocytes during meiotic division. PeerJ 5 e3295 PMID: 28533957

Chelakkot et al (2017) Intestinal Epithelial Cell-Specific Deletion of PLD2 Alleviates DSS-Induced Colitis by Regulating Occludin. Sci Rep 7 1573 PMID: 28484281


Do you know of a great paper that uses VU 0364739 hydrochloride from Tocris? Please let us know.

Reviews for VU 0364739 hydrochloride

There are currently no reviews for this product. Be the first to review VU 0364739 hydrochloride and earn rewards!

Have you used VU 0364739 hydrochloride?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Cardiovascular

Cardiovascular Research Product Guide

A collection of over 250 products for cardiovascular research, the guide includes research tools for the study of:

  • Hypertension
  • Thrombosis and Hemostasis
  • Atherosclerosis
  • Myocardial Infarction
  • Ischemia/Reperfusion Injury
  • Arrhythmias
  • Heart Failure
Asthma

Asthma Poster

Asthma is one of the most common chronic diseases in the world, affecting over 300 million people. This poster highlights key pathways and new therapies used to treat the condition, including those currently in clinical development.