VU 0238429

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Cat.No. 3634 - VU 0238429 | C17H12F3NO4 | CAS No. 1160247-92-6
Description: Selective positive allosteric modulator of M5 receptors
Chemical Name: 1-(4-Methoxybenzyl)-5-trifluoromethoxyisatin
Purity: ≥99% (HPLC)
Datasheet
Citations
Reviews
Literature (5)

Biological Activity

Selective positive allosteric modulator of M5 receptors (EC50 values are 1.16, >30 and >30 μM at M5, M1 and M3 receptors respectively). Displays no activity at M2 and M4 receptors.

Compound Libraries

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Technical Data

M. Wt 351.28
Formula C17H12F3NO4
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 1160247-92-6
PubChem ID 42633508
InChI Key CKLGZXFOLMHCMC-UHFFFAOYSA-N
Smiles O=C(C1=CC(OC(F)(F)F)=CC=C1N2CC3=CC=C(OC)C=C3)C2=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 35.13 100

Preparing Stock Solutions

The following data is based on the product molecular weight 351.28. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.85 mL 14.23 mL 28.47 mL
5 mM 0.57 mL 2.85 mL 5.69 mL
10 mM 0.28 mL 1.42 mL 2.85 mL
50 mM 0.06 mL 0.28 mL 0.57 mL

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References

References are publications that support the biological activity of the product.

Bridges et al (2009) Discovery of the first highly M5-preferring muscarinic acetylcholine receptor ligand, an M5 positive allosteric modulator derived from a series of 5-trifluoromethoxy N-benzyl isatins. J.Med.Chem. 52 3445 PMID: 19438238


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Keywords: VU 0238429, VU 0238429 supplier, Selective, positive, allosteric, modulators, PAMs, M5, receptors, Muscarinic, Acetylcholine, Ach, VU0238429, Receptors, 3634, Tocris Bioscience

Citations for VU 0238429

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