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Potent and selective phospholipase D1 (PLD1) inhibitor (IC50 values are 46 and 933 nM for PLD1 and PLD2 respectively). Inhibits migration of human and mouse breast cancer cell lines in transwell assays.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 499.43. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2 mL||10.01 mL||20.02 mL|
|5 mM||0.4 mL||2 mL||4 mL|
|10 mM||0.2 mL||1 mL||2 mL|
|50 mM||0.04 mL||0.2 mL||0.4 mL|
References are publications that support the biological activity of the product.
Scott et al (2009) Design of isoform-selective phospholipase D inhibitors that modulate cancer cell invasiveness. Nat.Chem.Biol. 5 108 PMID: 19136975
Lewis et al (2009) Design and synthesis of isoform-selective phospholipase D (PLD) inhibitors. Part I: Impact of alternative halogenated privileged structures for PLD1 specificity. Bioorg.Med.Chem.Lett. 19 1916 PMID: 19268584
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Keywords: VU 0155069, VU 0155069 supplier, VU0155069, PLD1, phospholipases, D, specific, inhibitors, inhibits, potent, selective, esterases, Phospholipases, 3575, Tocris Bioscience
3 Citations for VU 0155069
Citations are publications that use Tocris products. Selected citations for VU 0155069 include:
Lu et al (2018) An Antithrombotic Strategy by Targeting Phospholipase D in Human Platelets. J Clin Med 7 PMID: 30441821
Krishnan et al (2018) Elevated phopholipase D isoform 1 in Alzheimer's disease patient' hippocampus. Relevance to synaptic dysfunction and memory deficits. Alzheimers Dement (N Y) 4 89 PMID: 29560412
Sulzmaier et al (2012) PEA-15 potentiates H-Ras-mediated epithelial cell transformation through phospholipase D. Oncogene 31 3547 PMID: 22105357
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