VU 0155069

Pricing Availability   Qty
Description: Potent and selective PLD1 inhibitor
Chemical Name: N-[(1S)-2-[4-(5-Chloro-2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)-1-piperidinyl]-1-methylethyl-2-naphthalenecarboxamide
Purity: ≥98% (HPLC)
Datasheet
Citations (5)
Reviews

Biological Activity for VU 0155069

VU 0155069 is a potent and selective phospholipase D1 (PLD1) inhibitor (IC50 values are 46 and 933 nM for PLD1 and PLD2 respectively). Inhibits migration of human and mouse breast cancer cell lines in transwell assays.

Compound Libraries for VU 0155069

VU 0155069 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for VU 0155069

M. Wt 499.43
Formula C26H27ClN4O2.HCl
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1781834-89-6
PubChem ID 56972237
InChI Key RQULTQQAHGYYDG-LMOVPXPDSA-N
Smiles O=C(N[C@@H](C)CN3CCC(N5C4=C(NC5=O)C=C(Cl)C=C4)CC3)C(C=C2)=CC1=C2C=CC=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for VU 0155069

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 49.94 100
ethanol 24.97 50

Preparing Stock Solutions for VU 0155069

The following data is based on the product molecular weight 499.43. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2 mL 10.01 mL 20.02 mL
5 mM 0.4 mL 2 mL 4 mL
10 mM 0.2 mL 1 mL 2 mL
50 mM 0.04 mL 0.2 mL 0.4 mL

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References for VU 0155069

References are publications that support the biological activity of the product.

Scott et al (2009) Design of isoform-selective phospholipase D inhibitors that modulate cancer cell invasiveness. Nat.Chem.Biol. 5 108 PMID: 19136975

Lewis et al (2009) Design and synthesis of isoform-selective phospholipase D (PLD) inhibitors. Part I: Impact of alternative halogenated privileged structures for PLD1 specificity. Bioorg.Med.Chem.Lett. 19 1916 PMID: 19268584


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Keywords: VU 0155069, VU 0155069 supplier, VU0155069, PLD1, phospholipases, D, specific, inhibitors, inhibits, potent, selective, esterases, Phospholipases, 3575, Tocris Bioscience

5 Citations for VU 0155069

Citations are publications that use Tocris products. Selected citations for VU 0155069 include:

Gang et al (2017) PLD1 promotes dendritic spine development by inhibiting ADAM10-mediated N-cadherin cleavage. Sci Rep 7 6035 PMID: 28729535

Sulzmaier et al (2012) PEA-15 potentiates H-Ras-mediated epithelial cell transformation through phospholipase D. Oncogene 31 3547 PMID: 22105357

Krishnan et al (2018) Elevated phopholipase D isoform 1 in Alzheimer's disease patient' hippocampus. Relevance to synaptic dysfunction and memory deficits. Alzheimers Dement (N Y) 4 89 PMID: 29560412

Eckart D et al (2020) CtBP1-Mediated Membrane Fission Contributes to Effective Recycling of Synaptic Vesicles. Cell Rep 30 2444-2459.e7 PMID: 32075774


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