VU 0155069

Pricing Availability Delivery Time Qty
Cat.No. 3575 - VU 0155069 | C26H27ClN4O2.HCl | CAS No. 1130067-06-9
Description: Potent and selective PLD1 inhibitor
Chemical Name: N-[(1S)-2-[4-(5-Chloro-2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)-1-piperidinyl]-1-methylethyl-2-naphthalenecarboxamide
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Literature

Biological Activity

Potent and selective phospholipase D1 (PLD1) inhibitor (IC50 values are 46 and 933 nM for PLD1 and PLD2 respectively). Inhibits migration of human and mouse breast cancer cell lines in transwell assays.

Compound Libraries

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Technical Data

M. Wt 499.43
Formula C26H27ClN4O2.HCl
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1130067-06-9
PubChem ID 56972237
InChI Key RQULTQQAHGYYDG-LMOVPXPDSA-N
Smiles O=C(N[C@@H](C)CN3CCC(N5C4=C(NC5=O)C=C(Cl)C=C4)CC3)C(C=C2)=CC1=C2C=CC=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 49.94 100
ethanol 24.97 50

Preparing Stock Solutions

The following data is based on the product molecular weight 499.43. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2 mL 10.01 mL 20.02 mL
5 mM 0.4 mL 2 mL 4 mL
10 mM 0.2 mL 1 mL 2 mL
50 mM 0.04 mL 0.2 mL 0.4 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Scott et al (2009) Design of isoform-selective phospholipase D inhibitors that modulate cancer cell invasiveness. Nat.Chem.Biol. 5 108 PMID: 19136975

Lewis et al (2009) Design and synthesis of isoform-selective phospholipase D (PLD) inhibitors. Part I: Impact of alternative halogenated privileged structures for PLD1 specificity. Bioorg.Med.Chem.Lett. 19 1916 PMID: 19268584


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Keywords: VU 0155069, supplier, VU0155069, PLD1, phospholipases, D, specific, inhibitors, inhibits, potent, selective, esterases, Phospholipases, Phospholipases, Tocris Bioscience

1 Citation for VU 0155069

Citations are publications that use Tocris products. Selected citations for VU 0155069 include:

Sulzmaier et al (2012) PEA-15 potentiates H-Ras-mediated epithelial cell transformation through phospholipase D. Oncogene 31 3547 PMID: 22105357


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Literature in this Area

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