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Selective mitotic microtubule antagonist that exhibits > 20 fold selectivity over axonal microtubules. Inhibits proliferation of multiple human tumor cell lines (IC50 = 1.25 nM in HeLa cells) and blocks metaphase/anaphase transition by suppression of microtubule dynamics (IC50 = 3.8 nM). Reduces spindle length by 29% and inhibits microtubule polymerization at micromolar concentrations.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 1079.1. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||0.93 mL||4.63 mL||9.27 mL|
|5 mM||0.19 mL||0.93 mL||1.85 mL|
|10 mM||0.09 mL||0.46 mL||0.93 mL|
|50 mM||0.02 mL||0.09 mL||0.19 mL|
References are publications that support the biological activity of the product.
Budman (1997) Vinorelbine (Navelbine): A third generation vinca alkaloid. Cancer Invest. 15 475 PMID: 9316630
Ngan et al (2001) Mechanism of mitotic block and inhibition of cell proliferation by the semisynthetic vinca alkaloids vinore. and its newer derivative vinflunine. Mol.Pharmacol. 60 225 PMID: 11408618
Okouneva et al (2003) The effects of vinflunine, vinorelbine, and vinbla. on centromere dynamics. Mol.Cancer Ther. 2 427 PMID: 12748304
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Keywords: Vinorelbine ditartrate, Vinorelbine ditartrate supplier, Selective, mitotic, microtubule, antagonists, Tau, Tubulin, chemotherapeutics, Navelbine, Microtubules, Mitosis, 3401, Tocris Bioscience
1 Citation for Vinorelbine ditartrate
Citations are publications that use Tocris products. Selected citations for Vinorelbine ditartrate include:
Mavroeidis et al (2015) Metronomic vinorelbine: Anti-angiogenic activity in vitro in normoxic and severe hypoxic conditions, and severe hypoxia-induced resistance to its anti-proliferative effect with reversal by Akt inhibition. Front Cell Neurosci 47 455 PMID: 26095084
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