Vinorelbine ditartrate

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Cat.No. 3401 - Vinorelbine ditartrate | C45H54N4O8.2C4H6O6 | CAS No. 125317-39-7
Description: Selective mitotic microtubule antagonist
Alternative Names: Navelbine
Chemical Name: (2β,3β,4β,5α,12R,19α)-4-(Acetyloxy)-6,7-didehydro-15-[(2R,6R,8S)-4-ethyl-1,3,6,7,8,9-hexahydro-8-(methoxycarbonyl)-2,6-methano-2H-azecino[4,3-b]indol-8-yl]-3-hydroxy-16-methoxy-1-methylaspidospermidine-3-carboxylic acid methyl ester
Purity: ≥97% (HPLC)
Datasheet
Citations (1)
Literature

Biological Activity

Selective mitotic microtubule antagonist that exhibits > 20 fold selectivity over axonal microtubules. Inhibits proliferation of multiple human tumor cell lines (IC50 = 1.25 nM in HeLa cells) and blocks metaphase/anaphase transition by suppression of microtubule dynamics (IC50 = 3.8 nM). Reduces spindle length by 29% and inhibits microtubule polymerization at micromolar concentrations.

Technical Data

M. Wt 1079.1
Formula C45H54N4O8.2C4H6O6
Storage Store at -20°C
Purity ≥97% (HPLC)
CAS Number 125317-39-7
PubChem ID 5311497
InChI Key GBABOYUKABKIAF-IELIFDKJSA-N
Smiles [H][C@@]23N(C)C1=CC(OC)=[C@]([C@@](C7=C(C9)C(C=CC=C8)=C8N7)([C@](OC)=O)C[C@]6([H])C=C(CC)CN9C6)C=C1[C@@]52[C@](N(CC5)CC=C4)([H])[C@]4(CC)[C@@H](OC(C)=O)[C@]([C@](OC)=O)3O.O=C(O)C(O)C(O)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 107.91 100
water 107.91 100

Preparing Stock Solutions

The following data is based on the product molecular weight 1079.1. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.93 mL 4.63 mL 9.27 mL
5 mM 0.19 mL 0.93 mL 1.85 mL
10 mM 0.09 mL 0.46 mL 0.93 mL
50 mM 0.02 mL 0.09 mL 0.19 mL

Molarity Calculator

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Budman (1997) Vinorelbine (Navelbine): A third generation vinca alkaloid. Cancer Invest. 15 475 PMID: 9316630

Ngan et al (2001) Mechanism of mitotic block and inhibition of cell proliferation by the semisynthetic vinca alkaloids vinorelbine and its newer derivative vinflunine. Mol.Pharmacol. 60 225 PMID: 11408618

Okouneva et al (2003) The effects of vinflunine, vinorelbine, and vinblastine on centromere dynamics. Mol.Cancer Ther. 2 427 PMID: 12748304


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Keywords: Selective mitotic microtubule antagonists Tau Tubulin chemotherapeutics Navelbine Microtubules

1 Citation for Vinorelbine ditartrate

Citations are publications that use Tocris products. Selected citations for Vinorelbine ditartrate include:

Mavroeidis et al (2015) Metronomic vinorelbine: Anti-angiogenic activity in vitro in normoxic and severe hypoxic conditions, and severe hypoxia-induced resistance to its anti-proliferative effect with reversal by Akt inhibition. Front Cell Neurosci 47 455 PMID: 26095084


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