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Cat.No. 0808 - Vigabatrin | C6H11NO2 | CAS No. 60643-86-9
Description: GABA-T inhibitor
Alternative Names: (±)-γ-Vinyl GABA
Chemical Name: 4-Aminohexenoic acid
Purity: ≥98%
Citations (1)

Biological Activity

Selective GABA-T (transaminase) inhibitor. Anticonvulsant.

Technical Data

M. Wt 129.16
Formula C6H11NO2
Storage Desiccate at +4°C
Purity ≥98%
CAS Number 60643-86-9
PubChem ID 5665
Smiles NC(C=C)CCC(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
phosphate buffered saline 12.92 100
water 12.92 100

Preparing Stock Solutions

The following data is based on the product molecular weight 129.16. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 7.74 mL 38.71 mL 77.42 mL
5 mM 1.55 mL 7.74 mL 15.48 mL
10 mM 0.77 mL 3.87 mL 7.74 mL
50 mM 0.15 mL 0.77 mL 1.55 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References are publications that support the products' biological activity.

Halonen et al (1991) Effects of vigabatrin (γ-vinyl GABA) on neurotransmission-related amino acids and on GABA and benzodiazepine receptor binding in rats. Epilepsia 32 242 PMID: 1672276

Larsson et al (1986) Differential effect of gamma-vinyl GABA and valproate on GABA transaminase from cultured neurones and astrocytes. Neuropharmacology 25 617 PMID: 3092125

Schmid et al (1996) Vigabatrin modulates benzodiazepine receptor activity in vivo: a positron emission tomography study in baboon. J.Pharmacol.Exp.Ther. 276 977 PMID: 8786578

If you know of a relevant reference for Vigabatrin, please let us know.

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1 Citation for Vigabatrin

Citations are publications that use Tocris products. Selected citations for Vigabatrin include:

Héja et al (2009) Glutamate uptake triggers transporter-mediated GABA release from astrocytes. Stem Cells Dev 4 e7153 PMID: 19777062

Do you know of a great paper that uses Vigabatrin from Tocris? If so please let us know.

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Literature in this Area

GABA Receptors

GABA Receptors Scientific Review

Written by Ian Martin, Norman Bowery and Susan Dunn, this review provides a history of the GABA receptor, as well as discussing the structure and function of the various subtypes and the clinical potential of receptor modulators; compounds available from Tocris are listed.