Selective GABA-T (transaminase) inhibitor. Anticonvulsant.
|Storage||Desiccate at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
|phosphate buffered saline||12.92||100|
Preparing Stock Solutions
The following data is based on the product molecular weight 129.16. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||7.74 mL||38.71 mL||77.42 mL|
|5 mM||1.55 mL||7.74 mL||15.48 mL|
|10 mM||0.77 mL||3.87 mL||7.74 mL|
|50 mM||0.15 mL||0.77 mL||1.55 mL|
References are publications that support the products' biological activity.
Halonen et al (1991) Effects of vigabatrin (γ-vinyl GABA) on neurotransmission-related amino acids and on GABA and benzodiazepine receptor binding in rats. Epilepsia 32 242 PMID: 1672276
Larsson et al (1986) Differential effect of gamma-vinyl GABA and valproate on GABA transaminase from cultured neurones and astrocytes. Neuropharmacology 25 617 PMID: 3092125
Schmid et al (1996) Vigabatrin modulates benzodiazepine receptor activity in vivo: a positron emission tomography study in baboon. J.Pharmacol.Exp.Ther. 276 977 PMID: 8786578
If you know of a relevant reference for Vigabatrin, please let us know.
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Keywords: Vigabatrin, supplier, GABA-T, inhibitors, inhibits, GABA-Transferase, Transferases, GABA, GABAA, GABAC, Receptors, GABAB, (±)-γ-Vinyl, (±)-gamma-Vinyl, (±)-g-Vinyl, GABA, Miscellaneous, GABA, GABAB, Receptors, Other, Transferases, Miscellaneous, GABA, Tocris Bioscience
1 Citation for Vigabatrin
Citations are publications that use Tocris products. Selected citations for Vigabatrin include:
Héja et al (2009) Glutamate uptake triggers transporter-mediated GABA release from astrocytes. Stem Cells Dev 4 e7153 PMID: 19777062
Do you know of a great paper that uses Vigabatrin from Tocris? If so please let us know.
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Literature in this Area
GABA Receptors Scientific Review
Written by Ian Martin, Norman Bowery and Susan Dunn, this review provides a history of the GABA receptor, as well as discussing the structure and function of the various subtypes and the clinical potential of receptor modulators; compounds available from Tocris are listed.