Vigabatrin

Pricing Availability   Qty
Cat.No. 0808 - Vigabatrin | C6H11NO2 | CAS No. 60643-86-9
Description: GABA-T inhibitor
Alternative Names: (±)-γ-Vinyl GABA
Chemical Name: 4-Aminohexenoic acid
Purity: ≥98%
Datasheet
Citations (1)
Reviews
Literature

Biological Activity

Selective GABA-T (transaminase) inhibitor. Anticonvulsant.

Technical Data

M. Wt 129.16
Formula C6H11NO2
Storage Desiccate at +4°C
Purity ≥98%
CAS Number 60643-86-9
PubChem ID 5665
InChI Key PJDFLNIOAUIZSL-UHFFFAOYSA-N
Smiles NC(C=C)CCC(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 12.92 100

Preparing Stock Solutions

The following data is based on the product molecular weight 129.16. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 7.74 mL 38.71 mL 77.42 mL
5 mM 1.55 mL 7.74 mL 15.48 mL
10 mM 0.77 mL 3.87 mL 7.74 mL
50 mM 0.15 mL 0.77 mL 1.55 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets

Certificate of Analysis / Product Datasheet
Select another batch:

References

References are publications that support the biological activity of the product.

Halonen et al (1991) Effects of vigabatrin (γ-vinyl GABA) on neurotransmission-related amino acids and on GABA and benzodiazepine receptor binding in rats. Epilepsia 32 242 PMID: 1672276

Larsson et al (1986) Differential effect of gamma-vinyl GABA and valproate on GABA transaminase from cultured neurones and astrocytes. Neuropharmacology 25 617 PMID: 3092125

Schmid et al (1996) Vigabatrin modulates benzodiazepine receptor activity in vivo: a positron emission tomography study in baboon. J.Pharmacol.Exp.Ther. 276 977 PMID: 8786578


If you know of a relevant reference for Vigabatrin, please let us know.

Keywords: Vigabatrin, Vigabatrin supplier, GABA-T, inhibitors, inhibits, GABA-Transferase, Transferases, GABA, GABAA, GABAC, Receptors, GABAB, (±)-γ-Vinyl, (±)-gamma-Vinyl, (±)-g-Vinyl, Miscellaneous, Other, 0808, Tocris Bioscience

1 Citation for Vigabatrin

Citations are publications that use Tocris products. Selected citations for Vigabatrin include:

Héja et al (2009) Glutamate uptake triggers transporter-mediated GABA release from astrocytes. Stem Cells Dev 4 e7153 PMID: 19777062


Do you know of a great paper that uses Vigabatrin from Tocris? Please let us know.

Reviews for Vigabatrin

There are currently no reviews for this product. Be the first to review Vigabatrin and earn rewards!

Have you used Vigabatrin?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


GABA Receptors

GABA Receptors Scientific Review

Written by Ian Martin, Norman Bowery and Susan Dunn, this review provides a history of the GABA receptor, as well as discussing the structure and function of the various subtypes and the clinical potential of receptor modulators; compounds available from Tocris are listed.