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Submit ReviewVigabatrin
Description: GABA-T inhibitor
Alternative Names: (±)-γ-Vinyl GABA
Chemical Name: 4-Aminohexenoic acid
Purity: ≥98%
Biological Activity
Selective GABA-T (transaminase) inhibitor. Anticonvulsant.
Technical Data
| M. Wt | 129.16 |
| Formula | C6H11NO2 |
| Storage | Desiccate at +4°C |
| Purity | ≥98% |
| CAS Number | 60643-86-9 |
| PubChem ID | 5665 |
| InChI Key | PJDFLNIOAUIZSL-UHFFFAOYSA-N |
| Smiles | NC(C=C)CCC(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 12.92 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 129.16. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 7.74 mL | 38.71 mL | 77.42 mL |
| 5 mM | 1.55 mL | 7.74 mL | 15.48 mL |
| 10 mM | 0.77 mL | 3.87 mL | 7.74 mL |
| 50 mM | 0.15 mL | 0.77 mL | 1.55 mL |
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Product Datasheets
References
References are publications that support the biological activity of the product.
Halonen et al (1991) Effects of vigab. (γ-vinyl GABA) on neurotransmission-related amino acids and on GABA and benzodiazepine receptor binding in rats. Epilepsia 32 242 PMID: 1672276
Larsson et al (1986) Differential effect of gamma-vinyl GABA and valproate on GABA transaminase from cultured neurones and astrocytes. Neuropharmacology 25 617 PMID: 3092125
Schmid et al (1996) Vigabatrin modulates benzodiazepine receptor activity in vivo: a positron emission tomography study in baboon. J.Pharmacol.Exp.Ther. 276 977 PMID: 8786578
If you know of a relevant reference for Vigabatrin, please let us know.
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Keywords: Vigabatrin, Vigabatrin supplier, GABA-T, inhibitors, inhibits, GABA-Transferase, Transferases, GABA, GABAA, GABAC, Receptors, GABAB, (±)-γ-Vinyl, (±)-gamma-Vinyl, (±)-g-Vinyl, Miscellaneous, Other, 0808, Tocris Bioscience
2 Citations for Vigabatrin
Citations are publications that use Tocris products. Selected citations for Vigabatrin include:
Walters et al (2019) Preclinical tissue distribution and metabolic correlations of vigabatrin, an antiepileptic drug associated with potential use-limiting visual field defects. Pharmacol Res Perspect 7 e00456 PMID: 30631446
Héja et al (2009) Glutamate uptake triggers transporter-mediated GABA release from astrocytes. Stem Cells Dev 4 e7153 PMID: 19777062
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
GABA Receptors Scientific Review
Written by Ian Martin, Norman Bowery and Susan Dunn, this review provides a history of the GABA receptor, as well as discussing the structure and function of the various subtypes and the clinical potential of receptor modulators; compounds available from Tocris are listed.