Vialinin A

Pricing Availability   Qty
Cat.No. 4988 - Vialinin A | C34H26O8 | CAS No. 858134-23-3
Description: Inhibitor of USP4 and USP5/IsoT
Chemical Name: 1,1'-(4,4'',5',6'-Tetrahydroxy[1,1':4',1''-terphenyl]-2',3'-diyl) benzeneacetic acid ester
Purity: ≥98% (HPLC)
Citations (1)
Literature (1)

Biological Activity

Inhibitor of ubiquitin-specific peptidase 4 (USP4), USP5/isopeptidase T (IsoT) and UCH-L1 deubiquitinating enzyme (DUB) activity (IC50 values are 1.5, 5.9 and 22.3 μM, respectively). Shows no significant inhibition of UCH-L3, USP2, and USP8 activities. Decreases release of TNF-α (IC50 = 0.09 nM) from RBL-2H3 mast cells. Displays anti-cancer activity decreasing viability in human colonic carcinoma cells.

Technical Data

M. Wt 562.57
Formula C34H26O8
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 858134-23-3
PubChem ID 11563133
Smiles OC(C(O)=C(C3=CC=C(O)C=C3)C(OC(CC4=CC=CC=C4)=O)=C2OC(CC5=CC=CC=C5)=O)=C2C1=CC=C(O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 11.25 20

Preparing Stock Solutions

The following data is based on the product molecular weight 562.57. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 8.89 mL 44.44 mL 88.88 mL
1 mM 1.78 mL 8.89 mL 17.78 mL
2 mM 0.89 mL 4.44 mL 8.89 mL
10 mM 0.18 mL 0.89 mL 1.78 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Product Datasheets

Certificate of Analysis / Product Datasheet
Select another batch:


References are publications that support the biological activity of the product.

Norikura et al (2011) Anticancer activities of thelephantin O and vialinin A isolated from Thelephora aurantiotincta. J.Agric.Food Chem. 59 6974 PMID: 21630659

Okada et al (2013) Vialinin A is a ubiquitin-specific peptidase inhibitor. Bioorg.Med.Chem.Lett. 23 4328 PMID: 23791076

Onose et al (2012) Inhibitory effects of vialinin A and its analog on tumor necrosis factor-α release and production from RBL-2H3 cells. Cell Immunol. 279 140 PMID: 23246504

If you know of a relevant reference for Vialinin A, please let us know.

View Related Products by Product Action

View all Deubiquitinating Enzyme Inhibitors

Keywords: Vialinin A, Vialinin A supplier, inhibitors, inhibits, ubquitin, ubquitination, ubiquitin-specific, peptidase, 4, USP4, USP5, isopeptidase, T, IsoT, UCH-L1, deubiquitinating, enzymes, DUB, TNF-a, TNF-alpha, TNF, anti-cancer, Deubiquitinating, Enzymes, 4988, Tocris Bioscience

1 Citation for Vialinin A

Citations are publications that use Tocris products. Selected citations for Vialinin A include:

Lin et al (2017) USP4 interacts and positively regulates IRF8 function via K48-linked deubiquitination in regulatory T cells. FEBS Lett 591 1677 PMID: 28477415

Do you know of a great paper that uses Vialinin A from Tocris? Please let us know.

Reviews for Vialinin A

There are currently no reviews for this product. Be the first to review Vialinin A and earn rewards!

Have you used Vialinin A?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

New Product Guide

New Product Guide [Spring/Summer 2019]

Our new product guide highlights over 215 new products added to the Tocris Bioscience range during the first half of 2019.

  • 7-TM Receptors
  • Enzymes
  • Enzyme-Linked Receptors
  • Ion Channels
  • Nuclear Receptors
  • Transporters
  • Chemogenetics
  • Epigenetics
  • Fluorescent Imaging
  • Signal Transduction
  • Stem Cells