Vialinin A

Pricing Availability Delivery Time Qty
Cat.No. 4988 - Vialinin A | C34H26O8 | CAS No. 858134-23-3
Description: Inhibitor of USP4 and USP5/IsoT
Chemical Name: 1,1'-(4,4'',5',6'-Tetrahydroxy[1,1':4',1''-terphenyl]-2',3'-diyl) benzeneacetic acid ester
Purity: ≥98% (HPLC)

Biological Activity

Inhibitor of ubiquitin-specific peptidase 4 (USP4), USP5/isopeptidase T (IsoT) and UCH-L1 deubiquitinating enzyme (DUB) activity (IC50 values are 1.5, 5.9 and 22.3 μM, respectively). Shows no significant inhibition of UCH-L3, USP2, and USP8 activities. Decreases release of TNF-α (IC50 = 0.09 nM) from RBL-2H3 mast cells. Displays anti-cancer activity decreasing viability in human colonic carcinoma cells.

Technical Data

M. Wt 562.57
Formula C34H26O8
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 858134-23-3
PubChem ID 11563133
Smiles OC(C(O)=C(C3=CC=C(O)C=C3)C(OC(CC4=CC=CC=C4)=O)=C2OC(CC5=CC=CC=C5)=O)=C2C1=CC=C(O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 11.25 20

Preparing Stock Solutions

The following data is based on the product molecular weight 562.57. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.78 mL 8.89 mL 17.78 mL
5 mM 0.36 mL 1.78 mL 3.56 mL
10 mM 0.18 mL 0.89 mL 1.78 mL
50 mM 0.04 mL 0.18 mL 0.36 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References are publications that support the products' biological activity.

Norikura et al (2011) Anticancer activities of thelephantin O and vialinin A isolated from Thelephora aurantiotincta. J.Agric.Food Chem. 59 6974 PMID: 21630659

Okada et al (2013) Vialinin A is a ubiquitin-specific peptidase inhibitor. Bioorg.Med.Chem.Lett. 23 4328 PMID: 23791076

Onose et al (2012) Inhibitory effects of vialinin A and its analog on tumor necrosis factor-α release and production from RBL-2H3 cells. Cell Immunol. 279 140 PMID: 23246504

If you know of a relevant reference for Vialinin A, please let us know.

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View all Deubiquitinating Enzyme Inhibitors

Keywords: inhibitors inhibits ubquitin ubquitination ubiquitin-specific peptidase 4 USP4 USP5 isopeptidase T IsoT UCH-L1 deubiquitinating enzymes DUB TNF-a TNF-alpha TNF anti-cancer Deubiquitinating Enzymes

Citations for Vialinin A

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