Inhibitor of ubiquitin-specific peptidase 4 (USP4), USP5/isopeptidase T (IsoT) and UCH-L1 deubiquitinating enzyme (DUB) activity (IC50 values are 1.5, 5.9 and 22.3 μM, respectively). Shows no significant inhibition of UCH-L3, USP2, and USP8 activities. Decreases release of TNF-α (IC50 = 0.09 nM) from RBL-2H3 mast cells. Displays anti-cancer activity decreasing viability in human colonic carcinoma cells.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 562.57. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.78 mL||8.89 mL||17.78 mL|
|5 mM||0.36 mL||1.78 mL||3.56 mL|
|10 mM||0.18 mL||0.89 mL||1.78 mL|
|50 mM||0.04 mL||0.18 mL||0.36 mL|
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
References are publications that support the products' biological activity.
Norikura et al (2011) Anticancer activities of thelephantin O and vialinin A isolated from Thelephora aurantiotincta. J.Agric.Food Chem. 59 6974 PMID: 21630659
Okada et al (2013) Vialinin A is a ubiquitin-specific peptidase inhibitor. Bioorg.Med.Chem.Lett. 23 4328 PMID: 23791076
Onose et al (2012) Inhibitory effects of vialinin A and its analog on tumor necrosis factor-α release and production from RBL-2H3 cells. Cell Immunol. 279 140 PMID: 23246504
If you know of a relevant reference for Vialinin A, please let us know.
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Keywords: inhibitors inhibits ubquitin ubquitination ubiquitin-specific peptidase 4 USP4 USP5 isopeptidase T IsoT UCH-L1 deubiquitinating enzymes DUB TNF-a TNF-alpha TNF anti-cancer Deubiquitinating Enzymes
Citations for Vialinin A
Citations are publications that use Tocris products.
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Literature in this Area
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