Vialinin A

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Cat.No. 4988 - Vialinin A | C34H26O8 | CAS No. 858134-23-3
Description: Inhibitor of USP4 and USP5/IsoT
Chemical Name: 1,1'-(4,4'',5',6'-Tetrahydroxy[1,1':4',1''-terphenyl]-2',3'-diyl) benzeneacetic acid ester
Purity: ≥98% (HPLC)
Citations (1)

Biological Activity

Inhibitor of ubiquitin-specific peptidase 4 (USP4), USP5/isopeptidase T (IsoT) and UCH-L1 deubiquitinating enzyme (DUB) activity (IC50 values are 1.5, 5.9 and 22.3 μM, respectively). Shows no significant inhibition of UCH-L3, USP2, and USP8 activities. Decreases release of TNF-α (IC50 = 0.09 nM) from RBL-2H3 mast cells. Displays anti-cancer activity decreasing viability in human colonic carcinoma cells.

Technical Data

M. Wt 562.57
Formula C34H26O8
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 858134-23-3
PubChem ID 11563133
Smiles OC(C(O)=C(C3=CC=C(O)C=C3)C(OC(CC4=CC=CC=C4)=O)=C2OC(CC5=CC=CC=C5)=O)=C2C1=CC=C(O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 11.25 20

Preparing Stock Solutions

The following data is based on the product molecular weight 562.57. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 8.89 mL 44.44 mL 88.88 mL
1 mM 1.78 mL 8.89 mL 17.78 mL
2 mM 0.89 mL 4.44 mL 8.89 mL
10 mM 0.18 mL 0.89 mL 1.78 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References are publications that support the biological activity of the product.

Norikura et al (2011) Anticancer activities of thelephantin O and vialinin A isolated from Thelephora aurantiotincta. J.Agric.Food Chem. 59 6974 PMID: 21630659

Okada et al (2013) Vialinin A is a ubiquitin-specific peptidase inhibitor. Bioorg.Med.Chem.Lett. 23 4328 PMID: 23791076

Onose et al (2012) Inhibitory effects of vialinin A and its analog on tumor necrosis factor-α release and production from RBL-2H3 cells. Cell Immunol. 279 140 PMID: 23246504

If you know of a relevant reference for Vialinin A, please let us know.

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Keywords: Vialinin A, Vialinin A supplier, inhibitors, inhibits, ubquitin, ubquitination, ubiquitin-specific, peptidase, 4, USP4, USP5, isopeptidase, T, IsoT, UCH-L1, deubiquitinating, enzymes, DUB, TNF-a, TNF-alpha, TNF, anti-cancer, Deubiquitinating, Enzymes, 4988, Tocris Bioscience

1 Citation for Vialinin A

Citations are publications that use Tocris products. Selected citations for Vialinin A include:

Lin et al (2017) USP4 interacts and positively regulates IRF8 function via K48-linked deubiquitination in regulatory T cells. FEBS Lett 591 1677 PMID: 28477415

Do you know of a great paper that uses Vialinin A from Tocris? Please let us know.

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