URB 602

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Cat.No. 6020 - URB 602 | C19H21NO2 | CAS No. 565460-15-3
Description: Non-competitive MAGL inhibitor
Chemical Name: N-[1,1'-Biphenyl]-3-yl-carbamic acid cyclohexyl ester
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Non-competitive MAGL inhibitor. Exhibits selectivity for MAGL over FAAH, diacylglycerol lipase and COX2. Blocks 2-AG hydrolysis in rat brain slices. Enhances stress-induced analgesia in rats.

Technical Data

M. Wt 295.38
Formula C19H21NO2
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 565460-15-3
PubChem ID 10979337
InChI Key HHVUFQYJOSFTEH-UHFFFAOYSA-N
Smiles O=C(OC1CCCCC1)NC2=CC=CC(C3=CC=CC=C3)=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 29.54 100
ethanol 29.54 100

Preparing Stock Solutions

The following data is based on the product molecular weight 295.38. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.39 mL 16.93 mL 33.85 mL
5 mM 0.68 mL 3.39 mL 6.77 mL
10 mM 0.34 mL 1.69 mL 3.39 mL
50 mM 0.07 mL 0.34 mL 0.68 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Hohmann et al (2005) An endocannabinoid mechanism for stress-induced analgesia. Nature. 435 1108 PMID: 15973410

Makara et al (2005) Selective inhibition of 2-AG hydrolysis enhances endocannabinoid signaling in hippocampus. Nat.Neurosci. 8 1139 PMID: 16116451


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Keywords: URB 602, supplier, URB602, non-competitive, MAGL, inhibitors, inhibits, monoacylglycerol, lipases, MAGL, MAGL, Tocris Bioscience

Citations for URB 602

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