Urapidil hydrochloride

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Cat.No. 1772 - Urapidil hydrochloride | C20H29N5O3.HCl | CAS No. 64887-14-5
Description: α1 antagonist. Also 5-HT1A receptor agonist
Chemical Name: 6-[[3-[4-(2-Methoxyphenyl)-1-piperazinyl]propyl]amino]-1,3-dimethyl-2,4(1H,3H)-pyrimidinedione hydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

α1-adrenoceptor antagonist and 5-HT1A receptor agonist (pIC50 values are 6.13 and 6.4 respectively). Clinically used hypotensive agent.

Technical Data

M. Wt 423.94
Formula C20H29N5O3.HCl
Storage Desiccate at RT
Purity ≥99% (HPLC)
CAS Number 64887-14-5
PubChem ID 167980
InChI Key KTMLZVUAXJERAT-UHFFFAOYSA-N
Smiles Cl.COC1=CC=CC=C1N1CCN(CCCNC2=CC(=O)N(C)C(=O)N2C)CC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 21.2 50

Preparing Stock Solutions

The following data is based on the product molecular weight 423.94. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 4.72 mL 23.59 mL 47.18 mL
2.5 mM 0.94 mL 4.72 mL 9.44 mL
5 mM 0.47 mL 2.36 mL 4.72 mL
25 mM 0.09 mL 0.47 mL 0.94 mL

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References

References are publications that support the biological activity of the product.

Gross et al (1987) Urapidil and some analogues with hypotensive properties show high affinities for 5-hydroxytryptamine (5-HT) binding sites of the 5-HT1A subtype and for α1-adrenoceptor binding sites. Naunyn Schmiedebergs Arch.Pharmacol. 336 597 PMID: 2832770

Kolassa et al (1989) Involvement of brain 5-HT1A receptors in the hypotensive response to urapidil. Am.J.Cardiol. 64 7D PMID: 2569265

van Zwieten PA (1989) Pharmacologic profile of urapidil. Am.J.Cardiol. 64 1D PMID: 2569262


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Citations for Urapidil hydrochloride

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