Urapidil hydrochloride

Discontinued Product

Urapidil hydrochloride (Cat. No. 1772) has been withdrawn from sale for commercial reasons.
Description: α1 antagonist; also 5-HT1A receptor agonist
Chemical Name: 6-[[3-[4-(2-Methoxyphenyl)-1-piperazinyl]propyl]amino]-1,3-dimethyl-2,4(1H,3H)-pyrimidinedione hydrochloride
Purity: ≥99% (HPLC)
Literature (1)

Biological Activity for Urapidil hydrochloride

Urapidil hydrochloride is an α1-adrenoceptor antagonist and 5-HT1A receptor agonist (pIC50 values are 6.13 and 6.4 respectively). Clinically used hypotensive agent.

Technical Data for Urapidil hydrochloride

M. Wt 423.94
Formula C20H29N5O3.HCl
Storage Desiccate at RT
Purity ≥99% (HPLC)
CAS Number 64887-14-5
PubChem ID 167980

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for Urapidil hydrochloride

References for Urapidil hydrochloride

References are publications that support the biological activity of the product.

Gross et al (1987) Urapidil and some analogues with hypotensive properties show high affinities for 5-hydroxytryptamine (5-HT) binding sites of the 5-HT1A subtype and for α1-adrenoceptor binding sites. Naunyn Schmiedebergs Arch.Pharmacol. 336 597 PMID: 2832770

Kolassa et al (1989) Involvement of brain 5-HT1A receptors in the hypotensive response to urapidil. Am.J.Cardiol. 64 7D PMID: 2569265

van Zwieten PA (1989) Pharmacologic profile of urapidil. Am.J.Cardiol. 64 1D PMID: 2569262

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Citations for Urapidil hydrochloride

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Literature in this Area

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Depression Poster

Depression Poster

Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.