UPF 1069

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Cat.No. 3736 - UPF 1069 | C17H13NO3 | CAS No. 1048371-03-4
Description: PARP-2 inhibitor
Chemical Name: 5-(2-Oxo-2-phenylethoxy)-3,4-dihydroisoquinolin-1(2H)-one
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Selective poly(ADP-ribose) polymerase (PARP) 2 inhibitor (IC50 values are 0.3 and 8.0 μM for PARP-2 and PARP-1 respectively).

Compound Libraries

UPF 1069 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 279.29
Formula C17H13NO3
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 1048371-03-4
PubChem ID 25015515
InChI Key JJWMRRNGWSITSQ-UHFFFAOYSA-N
Smiles O=C2NC=CC1=C(OCC(C3=CC=CC=C3)=O)C=CC=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 27.93 100

Preparing Stock Solutions

The following data is based on the product molecular weight 279.29. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.58 mL 17.9 mL 35.81 mL
5 mM 0.72 mL 3.58 mL 7.16 mL
10 mM 0.36 mL 1.79 mL 3.58 mL
50 mM 0.07 mL 0.36 mL 0.72 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Moroni et al (2009) Selective PARP-2 inhibitors increase apoptosis in hippocampal slices but protect cortical cells in models of post-ischaemic brain damage. Br.J.Pharmacol. 157 854 PMID: 19422384

Pellicciari et al (2008) On the way to selective PARP-2 inhibitors. Design, synthesis and preliminary evaluation of a series of isoquinolinone derivatives. Chem.Med.Chem 3 914 PMID:


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Citations for UPF 1069

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Literature in this Area

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