UNC 926 hydrochloride

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Cat.No. 4516 - UNC 926 hydrochloride | C16H21BrN2O.HCl | CAS No. 1184136-10-4
Description: L3MBTL1 domain inhibitor
Chemical Name: (3-Bromophenyl)[4-(1-prrolidinyl)-1-piperidinyl]methanone hydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Methyl-lysine (Kme) reader domain inhibitor; binds to the MBT domain of the L3MBTL1 protein (Kd = 3.9 μM). Selectively inhibits the L3MBTL13XMBT-H4K20me1 interaction in a peptide pull down assay.

Compound Libraries

UNC 926 hydrochloride is also offered as part of the Tocriscreen Plus and Tocriscreen Epigenetics Toolbox. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 373.72
Formula C16H21BrN2O.HCl
Storage Desiccate at RT
Purity ≥99% (HPLC)
CAS Number 1184136-10-4
PubChem ID 90488947
InChI Key DPPMBBHOXQOMJI-UHFFFAOYSA-N
Smiles BrC1=CC=CC(C(N2CCC(N3CCCC3)CC2)=O)=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 37.37 100
ethanol 37.37 100
water 37.37 100

Preparing Stock Solutions

The following data is based on the product molecular weight 373.72. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.68 mL 13.38 mL 26.76 mL
5 mM 0.54 mL 2.68 mL 5.35 mL
10 mM 0.27 mL 1.34 mL 2.68 mL
50 mM 0.05 mL 0.27 mL 0.54 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Herold et al (2012) Structure-activity relationships of methyl-lysine reader antagonists. Med.Chem.Comm 3 45 PMID:


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View all MBT Domain Inhibitors

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Citations for UNC 926 hydrochloride

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Literature in this Area

Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

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Epigenetics

Epigenetics Scientific Review

Written by Susanne Müller-Knapp and Peter J. Brown, this review gives an overview of the development of chemical probes for epigenetic targets, as well as the impact of these tool compounds being made available to the scientific community. In addition, their biological effects are also discussed. Epigenetic compounds available from Tocris are listed.

Epigenetics

Epigenetics Research Bulletin

Produced by Tocris and updated in 2014, the epigenetics research bulletin gives an introduction into mechanisms of epigenetic regulation, and highlights key Tocris products for epigenetics targets including:

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  • DNA Methyltransferases
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  • Histone Demethylases
  • Histone Methyltransferases

Pathways for UNC 926 hydrochloride

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