UNC 926 hydrochloride

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Cat.No. 4516 - UNC 926 hydrochloride | C16H21BrN2O.HCl | CAS No. 1782573-49-2
Description: L3MBTL1 domain inhibitor
Chemical Name: (3-Bromophenyl)[4-(1-prrolidinyl)-1-piperidinyl]methanone hydrochloride
Purity: ≥99% (HPLC)
Literature (3)

Biological Activity

Methyl-lysine (Kme) reader domain inhibitor; binds to the MBT domain of the L3MBTL1 protein (Kd = 3.9 μM). Selectively inhibits the L3MBTL13XMBT-H4K20me1 interaction in a peptide pull down assay.

Technical Data

M. Wt 373.72
Formula C16H21BrN2O.HCl
Storage Desiccate at RT
Purity ≥99% (HPLC)
CAS Number 1782573-49-2
PubChem ID 90488947
Smiles BrC1=CC=CC(C(N2CCC(N3CCCC3)CC2)=O)=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
water 37.37 100
DMSO 37.37 100

Preparing Stock Solutions

The following data is based on the product molecular weight 373.72. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

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Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.68 mL 13.38 mL 26.76 mL
5 mM 0.54 mL 2.68 mL 5.35 mL
10 mM 0.27 mL 1.34 mL 2.68 mL
50 mM 0.05 mL 0.27 mL 0.54 mL

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References are publications that support the biological activity of the product.

Herold et al (2012) Structure-activity relationships of methyl-lysine reader antagonists. Med.Chem.Comm 3 45

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Citations for UNC 926 hydrochloride

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