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UNC 2399 is a biotinylated UNC 1999 (Cat.No. 4904, IC50 = 17 nM). Enriches lysine methyltransferase EZH2 from HEK293T cells.
Negative control also avilable.
This compound is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the UNC 1999 probe summary on the SGC website.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
The following data is based on the product molecular weight 1353.66. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.1 mM||7.39 mL||36.94 mL||73.87 mL|
|0.5 mM||1.48 mL||7.39 mL||14.77 mL|
|1 mM||0.74 mL||3.69 mL||7.39 mL|
|5 mM||0.15 mL||0.74 mL||1.48 mL|
References are publications that support the biological activity of the product.
If you know of a relevant reference for UNC 2399, please let us know.
Keywords: UNC 2399, UNC 2399 supplier, UNC2399, biotinylated, biotin, tag, EZH2, EZH1, histone, methyltransferase, inhibitors, inhibits, UNC1999, pull, down, PRC2, polycomb, repressive, complex, 2, Lysine, Methyltransferases, 4930, Tocris Bioscience
Citations are publications that use Tocris products. Selected citations for UNC 2399 include:
Konze et al (2013) An orally bioavailable chemical probe of the lysine methyltransferases EZH2 and EZH1. ACS.Chem.Biol. 8 1324 PMID: 23614352
Do you know of a great paper that uses UNC 2399 from Tocris? Please let us know.
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