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Submit ReviewUNC 2399
Discontinued Product
UNC 2399 (Cat. No. 4930) has been withdrawn from sale for commercial reasons.
Description: Biotinylated UNC 1999 (Cat.No. 4904)
Chemical Name: 1-Isopropyl-N-[(6-methyl-2-oxo-4-propyl-1,2-dihydropyridin-3-yl)methyl]-6-[6-[4-[41-oxo-45-[(3aS,4aS,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]-4,7,10,13,16,19,22,25,28,31,34,37-dodecaoxa-40-azapentatetracontan-1oyl]piperazin-1-yl]pyridin-3-yl]-1H-indazole-4-carboxamide
Purity: ≥95% (HPLC)
Biological Activity for UNC 2399
UNC 2399 is a biotinylated UNC 1999 (Cat.No. 4904, IC50 = 17 nM). Enriches lysine methyltransferase EZH2 from HEK293T cells.
Negative control also avilable.
Licensing Information
This compound is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the UNC 1999 probe summary on the SGC website.
Technical Data for UNC 2399
| M. Wt | 1353.66 |
| Formula | C67H104N10O17S |
| Storage | Store at -20°C |
| Purity | ≥95% (HPLC) |
| CAS Number | 2412791-72-9 |
| PubChem ID | 118732748 |
| InChI Key | PSDIDGKZEPMSHC-FRQYIUQJSA-N |
| Smiles | CC(C)N(N=C1)C2=C1C(C(NCC3=C(CCC)C=C(C)NC3=O)=O)=CC(C(C=C4)=CN=C4N5CCN(C(CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCNC(CCCC[C@H]6[C@]([H])([C@]([H])(CS6)N7)NC7=O)=O)=O)CC5)=C2 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for UNC 2399
References for UNC 2399
References are publications that support the biological activity of the product.
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Keywords: UNC 2399, UNC 2399 supplier, UNC2399, biotinylated, biotin, tag, EZH2, EZH1, histone, methyltransferase, inhibitors, inhibits, UNC1999, pull, down, PRC2, polycomb, repressive, complex, 2, Lysine, Methyltransferases, 4930, Tocris Bioscience
1 Citation for UNC 2399
Citations are publications that use Tocris products. Selected citations for UNC 2399 include:
Konze et al (2013) An orally bioavailable chemical probe of the lysine methyltransferases EZH2 and EZH1. ACS.Chem.Biol. 8 1324 PMID: 23614352
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Epigenetics Scientific Review
Written by Susanne Müller-Knapp and Peter J. Brown, this review gives an overview of the development of chemical probes for epigenetic targets, as well as the impact of these tool compounds being made available to the scientific community. In addition, their biological effects are also discussed. Epigenetic compounds available from Tocris are listed.
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Written by Kirsty E. Clarke, Victoria B. Christie, Andy Whiting and Stefan A. Przyborski, this review provides an overview of the use of small molecules in the control of stem cell growth and differentiation. Key signaling pathways are highlighted, and the regulation of ES cell self-renewal and somatic cell reprogramming is discussed. Compounds available from Tocris are listed.
Cancer Metabolism Poster
This poster summarizes the main metabolic pathways in cancer cells and highlights potential targets for cancer therapeutics. Genetic changes and epigenetic modifications in cancer cells alter the regulation of cellular metabolic pathways providing potential cancer therapeutic targets.
Epigenetics in Cancer Poster
This poster summarizes the main epigenetic targets in cancer. The dysregulation of epigenetic modifications has been shown to result in oncogenesis and cancer progression. Unlike genetic mutations, epigenetic alterations are considered to be reversible and thus make promising therapeutic targets.
Stem Cells Poster
Written by Rebecca Quelch and Stefan Przyborski from Durham University (UK), this poster describes the isolation of pluripotent stem cells, their maintenance in culture, differentiation, and the generation and potential uses of organoids.