UNC 2399

Pricing Availability Delivery Time Qty
Cat.No. 4930 - UNC 2399 | C67H104N10O17S
Description: Biotinylated UNC 1999 (Cat.No. 4904)
Chemical Name: 1-Isopropyl-N-[(6-methyl-2-oxo-4-propyl-1,2-dihydropyridin-3-yl)methyl]-6-[6-[4-[41-oxo-45-[(3aS,4aS,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]-4,7,10,13,16,19,22,25,28,31,34,37-dodecaoxa-40-azapentatetracontan-1oyl]piperazin-1-yl]pyridin-3-yl]-1H-indazole-4-carboxamide
Purity: ≥95% (HPLC)
Datasheet
Citations (1)
Literature

Biological Activity

Biotinylated UNC 1999 (Cat.No. 4904, IC50 = 17 nM). Enriches lysine methyltransferase EZH2 from HEK293T cells.

Licensing Information

This compound is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the UNC 1999 probe summary on the SGC website.

Technical Data

M. Wt 1353.66
Formula C67H104N10O17S
Storage Store at -20°C
Purity ≥95% (HPLC)
PubChem ID 118732748
InChI Key PSDIDGKZEPMSHC-FRQYIUQJSA-N
Smiles CC(C)N(N=C1)C2=C1C(C(NCC3=C(CCC)C=C(C)NC3=O)=O)=CC(C(C=C4)=CN=C4N5CCN(C(CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCNC(CCCC[C@H]6[C@]([H])([C@]([H])(CS6)N7)NC7=O)=O)=O)CC5)=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 13.54 10

Preparing Stock Solutions

The following data is based on the product molecular weight 1353.66. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.74 mL 3.69 mL 7.39 mL
5 mM 0.15 mL 0.74 mL 1.48 mL
10 mM 0.07 mL 0.37 mL 0.74 mL
50 mM 0.01 mL 0.07 mL 0.15 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

If you know of a relevant reference for UNC 2399, please let us know.

View Related Products by Target

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View all Lysine Methyltransferase Inhibitors

Keywords: UNC 2399, supplier, UNC2399, biotinylated, biotin, tag, EZH2, EZH1, histone, methyltransferase, inhibitors, inhibits, UNC1999, pull, down, PRC2, polycomb, repressive, complex, 2, Lysine, Methyltransferases, Lysine, Methyltransferases, Lysine, Methyltransferases, Tocris Bioscience

1 Citation for UNC 2399

Citations are publications that use Tocris products. Selected citations for UNC 2399 include:

Konze et al (2013) An orally bioavailable chemical probe of the lysine methyltransferases EZH2 and EZH1. ACS.Chem.Biol. 8 1324 PMID: 23614352


Do you know of a great paper that uses UNC 2399 from Tocris? If so please let us know.

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