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Description: Biotinylated UNC 1999 (Cat.No. 4904)
Chemical Name: 1-Isopropyl-N-[(6-methyl-2-oxo-4-propyl-1,2-dihydropyridin-3-yl)methyl]-6-[6-[4-[41-oxo-45-[(3aS,4aS,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]-4,7,10,13,16,19,22,25,28,31,34,37-dodecaoxa-40-azapentatetracontan-1oyl]piperazin-1-yl]pyridin-3-yl]-1H-indazole-4-carboxamide
Purity: ≥95% (HPLC)
Biological Activity for UNC 2399
UNC 2399 is a biotinylated UNC 1999 (Cat.No. 4904, IC50 = 17 nM). Enriches lysine methyltransferase EZH2 from HEK293T cells.
Negative control also avilable.
Licensing Information
This compound is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the UNC 1999 probe summary on the SGC website.
Technical Data for UNC 2399
| M. Wt | 1353.66 |
| Formula | C67H104N10O17S |
| Storage | Store at -20°C |
| Purity | ≥95% (HPLC) |
| PubChem ID | 118732748 |
| InChI Key | PSDIDGKZEPMSHC-FRQYIUQJSA-N |
| Smiles | CC(C)N(N=C1)C2=C1C(C(NCC3=C(CCC)C=C(C)NC3=O)=O)=CC(C(C=C4)=CN=C4N5CCN(C(CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCNC(CCCC[C@H]6[C@]([H])([C@]([H])(CS6)N7)NC7=O)=O)=O)CC5)=C2 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for UNC 2399
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 13.54 | 10 |
Preparing Stock Solutions for UNC 2399
The following data is based on the product molecular weight 1353.66. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 7.39 mL | 36.94 mL | 73.87 mL |
| 0.5 mM | 1.48 mL | 7.39 mL | 14.77 mL |
| 1 mM | 0.74 mL | 3.69 mL | 7.39 mL |
| 5 mM | 0.15 mL | 0.74 mL | 1.48 mL |
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Product Datasheets for UNC 2399
References for UNC 2399
References are publications that support the biological activity of the product.
If you know of a relevant reference for UNC 2399, please let us know.
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Keywords: UNC 2399, UNC 2399 supplier, UNC2399, biotinylated, biotin, tag, EZH2, EZH1, histone, methyltransferase, inhibitors, inhibits, UNC1999, pull, down, PRC2, polycomb, repressive, complex, 2, Lysine, Methyltransferases, 4930, Tocris Bioscience
1 Citation for UNC 2399
Citations are publications that use Tocris products. Selected citations for UNC 2399 include:
Konze et al (2013) An orally bioavailable chemical probe of the lysine methyltransferases EZH2 and EZH1. ACS.Chem.Biol. 8 1324 PMID: 23614352
Do you know of a great paper that uses UNC 2399 from Tocris? Please let us know.
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Epigenetics Scientific Review
Written by Susanne Müller-Knapp and Peter J. Brown, this review gives an overview of the development of chemical probes for epigenetic targets, as well as the impact of these tool compounds being made available to the scientific community. In addition, their biological effects are also discussed. Epigenetic compounds available from Tocris are listed.
Stem Cells Scientific Review
Written by Kirsty E. Clarke, Victoria B. Christie, Andy Whiting and Stefan A. Przyborski, this review provides an overview of the use of small molecules in the control of stem cell growth and differentiation. Key signaling pathways are highlighted, and the regulation of ES cell self-renewal and somatic cell reprogramming is discussed. Compounds available from Tocris are listed.
Epigenetics Research Bulletin
Produced by Tocris and updated in 2014, the epigenetics research bulletin gives an introduction into mechanisms of epigenetic regulation, and highlights key Tocris products for epigenetics targets including:
- Bromodomains
- DNA Methyltransferases
- Histone Deacetylases
- Histone Demethylases
- Histone Methyltransferases
Cancer Metabolism PosterUpdated
This poster summarizes the main metabolic pathways in cancer cells and highlights potential targets for cancer therapeutics. Genetic changes and epigenetic modifications in cancer cells alter the regulation of cellular metabolic pathways providing potential cancer therapeutic targets.
Epigenetics in Cancer PosterUpdated
This poster summarizes the main epigenetic targets in cancer. The dysregulation of epigenetic modifications has been shown to result in oncogenesis and cancer progression. Unlike genetic mutations, epigenetic alterations are considered to be reversible and thus make promising therapeutic targets.
Stem Cells Poster
Written by Rebecca Quelch and Stefan Przyborski from Durham University (UK), this poster describes the isolation of pluripotent stem cells, their maintenance in culture, differentiation, and the generation and potential uses of organoids.