UMB 68

Pricing Availability   Qty
Cat.No. 5518 - UMB 68 | C6H11NaO3 | CAS No. 581099-89-0
Description: GHB receptor ligand
Chemical Name: Sodium 4-Hydroxy-4methylpentanoate
Literature (6)

Biological Activity for UMB 68

UMB 68 is a GHB receptor ligand. Exhibits similar receptor afffinity as GHB (IC50 for displacement of 3[H]NCS-382 from GHB receptors is 38 μM compared with 25 μM for GHB). Demonstrates no significant affinity for GABAB receptors and does not exhibit GHB-like behavioral effects in vivo.

Technical Data for UMB 68

M. Wt 154.14
Formula C6H11NaO3
Storage Desiccate at RT
CAS Number 581099-89-0
PubChem ID 57340483
Smiles O=C(CCC(C)(O)C)O[Na]

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for UMB 68

Solvent Max Conc. mg/mL Max Conc. mM
water 15.41 100
DMSO 15.41 100

Preparing Stock Solutions for UMB 68

The following data is based on the product molecular weight 154.14. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 6.49 mL 32.44 mL 64.88 mL
5 mM 1.3 mL 6.49 mL 12.98 mL
10 mM 0.65 mL 3.24 mL 6.49 mL
50 mM 0.13 mL 0.65 mL 1.3 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

References for UMB 68

References are publications that support the biological activity of the product.

Wu et al (2003) A tertiary alcohol analog of γ-hydroxybutyric acid as a specific γ-hydroxybutyric acid receptor ligand. J.Pharmacol.Exp.Ther. 305 675 PMID: 12606613

If you know of a relevant reference for UMB 68, please let us know.

View Related Products by Target

Keywords: UMB 68, UMB 68 supplier, UMB68, gamma-hydroxybutyric, acid, γ, GHB, receptor, ligands, GABAb, GABAB, Receptors, 5518, Tocris Bioscience

Citations for UMB 68

Citations are publications that use Tocris products.

Currently there are no citations for UMB 68. Do you know of a great paper that uses UMB 68 from Tocris? Please let us know.

Reviews for UMB 68

There are currently no reviews for this product. Be the first to review UMB 68 and earn rewards!

Have you used UMB 68?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


GPCR Product Listing

A collection of over 450 products for G protein-coupled receptors, the listing includes research tools for the study of:

  • Rhodopsin-like Receptors
  • Glutamate Receptors
  • Frizzled Receptors
  • GPCR Signaling

Pain Research Product Guide

A collection of over 280 products for pain research, the guide includes research tools for the study of:

  • Nociception
  • Ion Channels
  • G-Protein-Coupled Receptors
  • Intracellular Signaling
GABA Receptors

GABA Receptors Scientific Review

Written by Ian Martin, Norman Bowery and Susan Dunn, this review provides a history of the GABA receptor, as well as discussing the structure and function of the various subtypes and the clinical potential of receptor modulators; compounds available from Tocris are listed.


Addiction Poster

The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.


Epilepsy Poster

Epilepsy is a brain disease that affects 60 million people globally. More than 20 anti-seizure drugs are currently available, but these do not address the underlying causes of the condition. This poster summarizes current knowledge about the development of the condition and highlights some approaches that have disease-modifying effects in proof-of-concept studies.


Schizophrenia Poster

Schizophrenia is a debilitating psychiatric disorder that affects 1% of the worldwide population. This poster describes the neurobiology of Schizophrenia, as well as highlighting the genetic and environmental factors that play a fundamental role in the etiology of the disease. The current and emerging drug targets are also discussed.