Potent and selective inhibitor of MMP-3 (IC50 = 5.9 nM). Displays selectivity over a range of MMPs (IC50 values are 73, 840, 1790, 1900 and 51000 for MMP-13, MMP-9, MMP-2, MMP-14 and MMP-1 respectively).
Sold for research purposes under agreement from Pfizer Inc.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 557.72. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.79 mL||8.97 mL||17.93 mL|
|5 mM||0.36 mL||1.79 mL||3.59 mL|
|10 mM||0.18 mL||0.9 mL||1.79 mL|
|50 mM||0.04 mL||0.18 mL||0.36 mL|
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
References are publications that support the products' biological activity.
Fray and Dickinson (2001) Discovery of potent and selective succinyl hydroxamate inhibitors of matrix metalloprotease-3 (stromelysin-1). Bioorg.Med.Chem.Lett. 11 571 PMID: 11229774
If you know of a relevant reference for UK 356618, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: UK 356618, supplier, pfizer, UK356618, matrix, metalloprotease, mmp, selective, inhibitors, inhibits, mmp-3, stromelysin, 1, progelatinase, matrix, metalloproteinase, Matrix, Metalloprotease, Tocris Bioscience
1 Citation for UK 356618
Citations are publications that use Tocris products. Selected citations for UK 356618 include:
Lee et al (2014) Nestin depletion induces melanoma matrix metalloproteinases and invasion. Lab Invest 94 1382 PMID: 25365206
Do you know of a great paper that uses UK 356618 from Tocris? If so please let us know.