UK 356618

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Cat.No. 4187 - UK 356618 | C34H43N3O4 | CAS No. 230961-08-7
Description: Potent and selective MMP-3 inhibitor
Chemical Name: N1-[(1S)-2,2-Dimethyl-1-[[[(1R)-1-phenylethyl]amino]carbonyl]propyl]-N4-hydroxy-2-[3-(2-methyl[1,1'-biphenyl]-4-yl)propyl]-butanediamine
Purity: ≥95% (HPLC)
Datasheet
Citations (1)
Reviews
Literature

Biological Activity

Potent and selective inhibitor of MMP-3 (IC50 = 5.9 nM). Displays selectivity over a range of MMPs (IC50 values are 73, 840, 1790, 1900 and 51000 for MMP-13, MMP-9, MMP-2, MMP-14 and MMP-1 respectively).

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Compound Libraries

UK 356618 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 557.72
Formula C34H43N3O4
Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 230961-08-7
PubChem ID 10370504
InChI Key JJHRUUKMPWUYIB-HVOSOHGQSA-N
Smiles CC1=C(C2=CC=CC=C2)C=CC(CCC[C@H](CC(NO)=O)C(N[C@H]([C@@](N[C@H](C)C3=CC=CC=C3)=O)C(C)(C)C)=O)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 55.77 100

Preparing Stock Solutions

The following data is based on the product molecular weight 557.72. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.79 mL 8.97 mL 17.93 mL
5 mM 0.36 mL 1.79 mL 3.59 mL
10 mM 0.18 mL 0.9 mL 1.79 mL
50 mM 0.04 mL 0.18 mL 0.36 mL

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References

References are publications that support the biological activity of the product.

Fray and Dickinson (2001) Discovery of potent and selective succinyl hydroxamate inhibitors of matrix metalloprotease-3 (stromelysin-1). Bioorg.Med.Chem.Lett. 11 571 PMID: 11229774


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View Related Products by Product Action

View all Matrix Metalloprotease Inhibitors

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1 Citation for UK 356618

Citations are publications that use Tocris products. Selected citations for UK 356618 include:

Lee et al (2014) Nestin depletion induces melanoma matrix metalloproteinases and invasion. Lab Invest 94 1382 PMID: 25365206


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Literature in this Area

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