UK 356618

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Cat.No. 4187 - UK 356618 | C34H43N3O4 | CAS No. 230961-08-7
Description: Potent and selective MMP-3 inhibitor
Chemical Name: N1-[(1S)-2,2-Dimethyl-1-[[[(1R)-1-phenylethyl]amino]carbonyl]propyl]-N4-hydroxy-2-[3-(2-methyl[1,1'-biphenyl]-4-yl)propyl]-butanediamine
Purity: ≥95% (HPLC)
Datasheet
Citations (1)
Literature

Biological Activity

Potent and selective inhibitor of MMP-3 (IC50 = 5.9 nM). Displays selectivity over a range of MMPs (IC50 values are 73, 840, 1790, 1900 and 51000 for MMP-13, MMP-9, MMP-2, MMP-14 and MMP-1 respectively).

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Compound Libraries

UK 356618 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 557.72
Formula C34H43N3O4
Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 230961-08-7
PubChem ID 10370504
InChI Key JJHRUUKMPWUYIB-HVOSOHGQSA-N
Smiles CC1=C(C2=CC=CC=C2)C=CC(CCC[C@H](CC(NO)=O)C(N[C@H]([C@@](N[C@H](C)C3=CC=CC=C3)=O)C(C)(C)C)=O)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 55.77 100

Preparing Stock Solutions

The following data is based on the product molecular weight 557.72. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.79 mL 8.97 mL 17.93 mL
5 mM 0.36 mL 1.79 mL 3.59 mL
10 mM 0.18 mL 0.9 mL 1.79 mL
50 mM 0.04 mL 0.18 mL 0.36 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Fray and Dickinson (2001) Discovery of potent and selective succinyl hydroxamate inhibitors of matrix metalloprotease-3 (stromelysin-1). Bioorg.Med.Chem.Lett. 11 571 PMID: 11229774


If you know of a relevant reference for UK 356618, please let us know.

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View all Matrix Metalloprotease Inhibitors

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1 Citation for UK 356618

Citations are publications that use Tocris products. Selected citations for UK 356618 include:

Lee et al (2014) Nestin depletion induces melanoma matrix metalloproteinases and invasion. Lab Invest 94 1382 PMID: 25365206


Do you know of a great paper that uses UK 356618 from Tocris? If so please let us know.

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Literature in this Area

Cancer

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Neurodegeneration

Neurodegeneration Product Guide

A collection of over 275 products for neurodegeneration research, the guide includes research tools for the study of:

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Angiogenesis in Cancer

Angiogenesis in Cancer Poster

Adapted from the 2015 Cancer Product Guide, Edition 3, this poster summarizes the pathogenesis of angiogenesis in cancer, as well as some of the main angiogenesis therapeutic targets.

Cardiovascular

Cardiovascular Poster

Cardiovascular disease remains one of the major causes of morbidity and mortality in the Western world and therefore this therapeutic area continues to be of great interest to researchers. This poster highlights the key GPCRs regulating vascular reactivity.

Pathways for UK 356618

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