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Potent and selective inhibitor of MMP-3 (IC50 = 5.9 nM). Displays selectivity over a range of MMPs (IC50 values are 73, 840, 1790, 1900 and 51000 for MMP-13, MMP-9, MMP-2, MMP-14 and MMP-1 respectively).
Sold for research purposes under agreement from Pfizer Inc.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 557.72. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.79 mL||8.97 mL||17.93 mL|
|5 mM||0.36 mL||1.79 mL||3.59 mL|
|10 mM||0.18 mL||0.9 mL||1.79 mL|
|50 mM||0.04 mL||0.18 mL||0.36 mL|
References are publications that support the biological activity of the product.
Fray and Dickinson (2001) Discovery of potent and selective succinyl hydroxamate inhibitors of matrix metalloprotease-3 (stromelysin-1). Bioorg.Med.Chem.Lett. 11 571 PMID: 11229774
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Keywords: UK 356618, UK 356618 supplier, pfizer, UK356618, matrix, metalloprotease, mmp, selective, inhibitors, inhibits, mmp-3, stromelysin, 1, progelatinase, metalloproteinase, Matrix, Metalloprotease, 4187, Tocris Bioscience
1 Citation for UK 356618
Citations are publications that use Tocris products. Selected citations for UK 356618 include:
Lee et al (2014) Nestin depletion induces melanoma matrix metalloproteinases and invasion. Lab Invest 94 1382 PMID: 25365206
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