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Description: Potent and selective RIPK3 inhibitor; also blocks activation of necroptosis
Chemical Name: 3-(3-Hydroxyphenyl)-1-methyl-7-[[3-(4-methyl-1-piperazinyl)phenyl]amino]-1,6-naphthyridin-2(1H)-one dihydrochloride
Purity: ≥98% (HPLC)

Biological Activity for UH15-38

UH15-38 is a potent and selective receptor interacting protein kinase 3 (RIPK3) inhibitor (IC50 = 20 nM). UH15-38 potently and selectively blocks influenza A-induced necroptosis in alveolar epithelial cells in vivo (IC50 = 39.5 nM), and prevents damage from lung inflammation without compromising antiviral adaptive immune responses or impeding viral clearance. Blocks TNFα-induced necroptosis in primary murine embryonic fibroblasts (IC50 = 98 nM) and mouse cell lines in vitro.

Scientific Data

Cell Viability Published vs Bio-Techne batch comparison for UH15-38 View Larger

Published vs Bio-Techne batch comparison for UH15-38. Inhibition of necroptosis by UH15-38 in human FADD-deficient Jurkat cells. Cells were treated with 10 ng/ml of human TNF alpha for 24 hr in the presence of the dose range of the inhibitors. Cell viability was determined using CellTiter-Glo assay (Promega). IC50 for the published molecule was 238.2 nM and 160.2 nM for the Bio-Techne batch. Data kindly provided by A. Degterev’s laboratory, University of Tufts.

Licensing Information

Sold under license from Tufts University

Technical Data for UH15-38

M. Wt 514.45
Formula C26H27N5O2.2HCl
Storage Store at -20°C
Purity ≥98% (HPLC)
Smiles O=C1C(C2=CC=CC(O)=C2)=CC3=C(N1C)C=C(NC4=CC=CC(N5CCN(CC5)C)=C4)N=C3.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for UH15-38

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 51.44 100
water 51.44 100

Preparing Stock Solutions for UH15-38

The following data is based on the product molecular weight 514.45. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.94 mL 9.72 mL 19.44 mL
5 mM 0.39 mL 1.94 mL 3.89 mL
10 mM 0.19 mL 0.97 mL 1.94 mL
50 mM 0.04 mL 0.19 mL 0.39 mL

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References for UH15-38

References are publications that support the biological activity of the product.

Gautam et al (2024) Necroptosis blockade prevents lung injury in severe influenza. Nature PMID: 38600381

If you know of a relevant reference for UH15-38, please let us know.

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Citations for UH15-38

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