UCM 707

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Cat.No. 1966 - UCM 707 | C25H37NO2 | CAS No. 390824-20-1
Description: Potent anandamide transport inhibitor
Chemical Name: (5Z,8Z,11Z,14Z)-N-(3-Furanylmethyl)-5,8,11,14-eicosatetraenamide
Datasheet
Citations
Literature

Biological Activity

Potent endocannabinoid transport inhibitor. IC50 values are 0.8 and 30 μM for inhibition of the anandamide transporter and FAAH respectively. Ki values are 4700, 67 and > 5000 nM for CB1, CB2 and VR1 receptors respectively. Potentiates hypokinetic and antinociceptive effects of anandamide in vivo.

Technical Data

M. Wt 383.57
Formula C25H37NO2
Storage Desiccate at -20°C
CAS Number 390824-20-1
PubChem ID 10199993
InChI Key FZNNBSHTNRBBBD-DOFZRALJSA-N
Smiles O=C(NCC1=COC=C1)CCC\C=C/C\C=C/C/C=C\C/C=C\CCCCC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 38.36 100
ethanol 38.36 100

Preparing Stock Solutions

The following data is based on the product molecular weight 383.57. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.61 mL 13.04 mL 26.07 mL
5 mM 0.52 mL 2.61 mL 5.21 mL
10 mM 0.26 mL 1.3 mL 2.61 mL
50 mM 0.05 mL 0.26 mL 0.52 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Lopez-Rodriguez et al (2003) Design, synthesis and biological evaluation of new endocannabinoid transporter inhibitors. Eur.J.Med.Chem. 38 403 PMID: 12750028

Lopez-Rodriguez et al (2003) Design, synthesis, and biological evaluation of new inhibitors of the endocannabinoid uptake: comparison with effects on fatty acid amidohydrolase. J.Med.Chem. 46 1512 PMID: 12672252


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Keywords: Potent anandamide transporters inhibitors inhibits AMT Anandamide cannabinoids Monoamine Neurotransmitter UCM707 Cannabinoid Transporters

Citations for UCM 707

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Literature in this Area

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Cannabinoid Receptor Ligands

Cannabinoid Receptor Ligands Scientific Review

Written by Roger Pertwee, this review discusses compounds which affect the activity of the endocannabinoid system, focusing particularly on ligands that are most widely used as experimental tools and denotes compounds available from Tocris.

Pathways for UCM 707

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