UCL 2077

Pricing Availability Delivery Time Qty
Cat.No. 2661 - UCL 2077 | C25H22N2 | CAS No. 918311-87-2
Description: Slow afterhyperpolarization (sAHP) channel blocker; sub-type selective Kv channel effects
Chemical Name: N-Trityl-3-pyridinemethanamine
Purity: ≥99% (HPLC)
Datasheet
Citations (1)
Reviews
Literature

Biological Activity

Slow afterhyperpolarization (sAHP) channel blocker; reduces sAHP in hippocampal slice preparations. Displays no effect on Ca2+ currents or the time course of sAHP/sIAHP. Exhibits potent inhibition of KCNQ1 and KCNQ2, but differential effects at other KCNQs. Rescues memory retrieval in dopamine β-hydroxylase knockout mice.

Compound Libraries

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Technical Data

M. Wt 350.46
Formula C25H22N2
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 918311-87-2
PubChem ID 24868317
InChI Key PQFNWDHABGBCHB-UHFFFAOYSA-N
Smiles C(NC(C1=CC=CC=C1)(C1=CC=CC=C1)C1=CC=CC=C1)C1=CN=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 17.52 50
ethanol 8.76 25

Preparing Stock Solutions

The following data is based on the product molecular weight 350.46. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.85 mL 14.27 mL 28.53 mL
5 mM 0.57 mL 2.85 mL 5.71 mL
10 mM 0.29 mL 1.43 mL 2.85 mL
50 mM 0.06 mL 0.29 mL 0.57 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the biological activity of the product.

Shah et al (2006) Enhancement of hippocampal pyramidal cell excitability by the novel selective slow-afterhyperpolarization channel blocker 3-(triphenylmethylaminomethyl)pyridine (UCL2077). Mol.Pharmacol. 70 1494 PMID: 16877678

Zhang et al (2013) The slow afterhyperpolarization: a target of β1-adrenergic signaling in hippocampus-dependent memory retrieval. J.Neurosci. 33 5006 PMID: 23486971

Soh and Tzingounis (2010) The specific slow afterhyperpolarization inhibitor UCL2077 is a subtype-selective blocker of the epilepsy associated KCNQ channels. Mol.Pharmacol. 78 1088 PMID: 20843955


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Keywords: UCL 2077, UCL 2077 supplier, Slow, hyperpolarization, sAHP, channels, blockers, Potassium, KCa, Channels, ca2+-activated, ca2+-dependent, K+, UCL2077, Ca2+-Activated, Voltage-Gated, 2661, Tocris Bioscience

1 Citation for UCL 2077

Citations are publications that use Tocris products. Selected citations for UCL 2077 include:

Zhang et al (2013) The slow afterhyperpolarization: a target of β1-adrenergic signaling in hippocampus-dependent memory retrieval. J Neurosci 33 5006 PMID: 23486971


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Literature in this Area

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Ion Channel

Ion Channel Product Listing

A collection of around 500 products for ion channel research, the listing includes research tools for the study of:

  • Ligand-gated ion channels
  • Voltage-gated ion channels
  • Other Ion Channels
Epilepsy

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Epilepsy is a brain disease that affects 60 million people globally. More than 20 anti-seizure drugs are currently available, but these do not address the underlying causes of the condition. This poster summarizes current knowledge about the development of the condition and highlights some approaches that have disease-modifying effects in proof-of-concept studies.