UBP 301

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Cat.No. 1766 - UBP 301 | C15H14IN3O6 | CAS No. 569371-10-4
Description: Kainate receptor antagonist
Chemical Name: (αS)-α-Amino-3-[(4-carboxyphenyl)methyl]-3,4-dihydro-5-iodo-2,4-dioxo-1(2H)-pyrimidinepropanoic acid
Purity: ≥98% (HPLC)
Datasheet
Citations (1)

Biological Activity

Potent kainate receptor antagonist (apparent Kd = 5.94 μM). Displays ~ 30-fold selectivity over AMPA receptors.

Technical Data

M. Wt 459.2
Formula C15H14IN3O6
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 569371-10-4
PubChem ID 6604913
InChI Key JHSYCOCOIYSZGI-NSHDSACASA-N
Smiles O=C(C(I)=CN1C[C@H](N)C(O)=O)N(CC2=CC=C(C(O)=O)C=C2)C1=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 2.3 5mM with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 459.2. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.18 mL 10.89 mL 21.78 mL
5 mM 0.44 mL 2.18 mL 4.36 mL
10 mM 0.22 mL 1.09 mL 2.18 mL
50 mM 0.04 mL 0.22 mL 0.44 mL

Molarity Calculator

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Reconstitution Calculator

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

More et al (2003) Structural requirements for novel willardiine derivatives acting as AMPA and kainate receptor antagonists. Br.J.Pharmacol. 138 1093 PMID: 12684265


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Keywords: Kainate receptor antagonists Glutamate Receptors iGluR Ionotropic UBP301 Kainate Receptors

1 Citation for UBP 301

Citations are publications that use Tocris products. Selected citations for UBP 301 include:

Cassé et al (2012) Glutamate controls tPA recycling by astrocytes, which in turn influences glutamatergic signals. J Neurosci 32 5186 PMID: 22496564


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