UBP 301

Pricing Availability   Qty
Description: Kainate antagonist
Chemical Name: (αS)-α-Amino-3-[(4-carboxyphenyl)methyl]-3,4-dihydro-5-iodo-2,4-dioxo-1(2H)-pyrimidinepropanoic acid
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Reviews
Literature (2)

Biological Activity for UBP 301

UBP 301 is a potent kainate receptor antagonist (apparent Kd = 5.94 μM). Displays ~ 30-fold selectivity over AMPA receptors.

Technical Data for UBP 301

M. Wt 459.2
Formula C15H14IN3O6
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 569371-10-4
PubChem ID 6604913
InChI Key JHSYCOCOIYSZGI-NSHDSACASA-N
Smiles O=C(C(I)=CN1C[C@H](N)C(O)=O)N(CC2=CC=C(C(O)=O)C=C2)C1=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for UBP 301

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 2.3 5 with gentle warming

Preparing Stock Solutions for UBP 301

The following data is based on the product molecular weight 459.2. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.05 mM 43.55 mL 217.77 mL 435.54 mL
0.25 mM 8.71 mL 43.55 mL 87.11 mL
0.5 mM 4.36 mL 21.78 mL 43.55 mL
2.5 mM 0.87 mL 4.36 mL 8.71 mL

Molarity Calculator

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

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Dilution Calculator

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Product Datasheets for UBP 301

Certificate of Analysis / Product Datasheet
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References for UBP 301

References are publications that support the biological activity of the product.

More et al (2003) Structural requirements for novel willardiine derivatives acting as AMPA and kainate receptor antagonists. Br.J.Pharmacol. 138 1093 PMID: 12684265


If you know of a relevant reference for UBP 301, please let us know.

View Related Products by Target

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View all Kainate Receptor Antagonists

Keywords: UBP 301, UBP 301 supplier, Kainate, receptor, antagonists, Glutamate, Receptors, iGluR, Ionotropic, UBP301, 1766, Tocris Bioscience

1 Citation for UBP 301

Citations are publications that use Tocris products. Selected citations for UBP 301 include:

Cassé et al (2012) Glutamate controls tPA recycling by astrocytes, which in turn influences glutamatergic signals. J Neurosci 32 5186 PMID: 22496564


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Reviews for UBP 301

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


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