UBP 296

Pricing Availability   Qty
Description: Potent and selective kainate antagonist; selective for GluK1-containing receptors
Chemical Name: (RS)-1-(2-Amino-2-carboxyethyl)-3-(2-carboxybenzyl)pyrimidine-2,4-dione
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Reviews
Literature (3)

Biological Activity for UBP 296

UBP 296 is a selective GluK1 (formally GluR5) subunit containing kainate receptor antagonist (apparent KD = 1.09 μM). Displays ~ 90-fold selectivity over AMPA receptors and recombinant hGluK2 (formally hGluR6) and GluK5 (formally KA2) containing kainate receptors. Has little or no action at NMDA or group I mGlu receptors. Selectively blocks kainate receptor-mediated LTP induction in rat hippocampal mossy fibers.

Active Enantiomer also available.

Please refer to IUPHAR Guide to Pharmacology for the most recent naming conventions.

Technical Data for UBP 296

M. Wt 333.3
Formula C15H15N3O6
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 745055-86-1
PubChem ID 11674376
InChI Key UUIYULWYHDSXHL-UHFFFAOYSA-N
Smiles NC(CN1C=CC(=O)N(CC2=C(C=CC=C2)C(O)=O)C1=O)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for UBP 296

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
1eq. NaOH 3.33 10 with gentle warming
DMSO 3.33 10

Preparing Stock Solutions for UBP 296

The following data is based on the product molecular weight 333.3. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 30 mL 150.02 mL 300.03 mL
0.5 mM 6 mL 30 mL 60.01 mL
1 mM 3 mL 15 mL 30 mL
5 mM 0.6 mL 3 mL 6 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

References for UBP 296

References are publications that support the biological activity of the product.

More et al (2004) Characterisation of UBP296: a novel, potent and selective kainate receptor antagonist. Neuropharmacology 47 46 PMID: 15165833

Dolman et al (2005) Synthesis and pharmacology of willardiine derivatives acting as antagonists of kainate receptors. J.Med.Chem. 48 7867 PMID: 16302825


If you know of a relevant reference for UBP 296, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Kainate Receptor Antagonists

Keywords: UBP 296, UBP 296 supplier, Selective, potent, kainate, antagonists, selective, GluR5-containing, receptors, Glutamate, Kainate, Receptors, iGluR, Ionotropic, UBP296, GluK1, 2078, Tocris Bioscience

1 Citation for UBP 296

Citations are publications that use Tocris products. Selected citations for UBP 296 include:

Albiñana et al (2015) Chondroitin Sulfate Induces Depression of Synaptic Transmission and Modulation of Neuronal Plasticity in Rat Hippocampal Slices. Neural Plast 2015 463854 PMID: 26075099


Do you know of a great paper that uses UBP 296 from Tocris? Please let us know.

Reviews for UBP 296

There are currently no reviews for this product. Be the first to review UBP 296 and earn rewards!

Have you used UBP 296?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Addiction Poster

Addiction Poster

The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.

Learning & Memory Poster

Learning & Memory Poster

Recognition memory enables us to make judgements about whether or not we have encountered a particular stimulus before. This poster outlines the cellular mechanisms underlying recognition memory and its links to long-term depression, as well as the use of pharmacological intervention to assess the role of neurotransmitters in recognition memory.

Parkinson's Disease Poster

Parkinson's Disease Poster

Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.