UBP 296

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Cat.No. 2078 - UBP 296 | C15H15N3O6 | CAS No. 745055-86-1
Description: Potent and selective kainate antagonist; selective for GluK1-containing receptors
Chemical Name: (RS)-1-(2-Amino-2-carboxyethyl)-3-(2-carboxybenzyl)pyrimidine-2,4-dione
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Reviews
Literature (8)

Biological Activity

Selective GluK1 (formally GluR5) subunit containing kainate receptor antagonist (apparent KD = 1.09 μM). Displays ~ 90-fold selectivity over AMPA receptors and recombinant hGluK2 (formally hGluR6) and GluK5 (formally KA2) containing kainate receptors. Has little or no action at NMDA or group I mGlu receptors. Selectively blocks kainate receptor-mediated LTP induction in rat hippocampal mossy fibers.

Active Enantiomer also available.

Please refer to IUPHAR Guide to Pharmacology for the most recent naming conventions.

Technical Data

M. Wt 333.3
Formula C15H15N3O6
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 745055-86-1
PubChem ID 11674376
InChI Key UUIYULWYHDSXHL-UHFFFAOYSA-N
Smiles NC(CN1C=CC(=O)N(CC2=C(C=CC=C2)C(O)=O)C1=O)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
1eq. NaOH 3.33 10 with gentle warming
DMSO 3.33 10

Preparing Stock Solutions

The following data is based on the product molecular weight 333.3. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 30 mL 150.02 mL 300.03 mL
0.5 mM 6 mL 30 mL 60.01 mL
1 mM 3 mL 15 mL 30 mL
5 mM 0.6 mL 3 mL 6 mL

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References

References are publications that support the biological activity of the product.

More et al (2004) Characterisation of UBP296: a novel, potent and selective kainate receptor antagonist. Neuropharmacology 47 46 PMID: 15165833

Dolman et al (2005) Synthesis and pharmacology of willardiine derivatives acting as antagonists of kainate receptors. J.Med.Chem. 48 7867 PMID: 16302825


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Keywords: UBP 296, UBP 296 supplier, Selective, potent, kainate, antagonists, selective, GluR5-containing, receptors, Glutamate, Kainate, Receptors, iGluR, Ionotropic, UBP296, GluK1, 2078, Tocris Bioscience

1 Citation for UBP 296

Citations are publications that use Tocris products. Selected citations for UBP 296 include:

Albiñana et al (2015) Chondroitin Sulfate Induces Depression of Synaptic Transmission and Modulation of Neuronal Plasticity in Rat Hippocampal Slices. Neural Plast 2015 463854 PMID: 26075099


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