UB 165 fumarate

Pricing Availability Delivery Time Qty
Cat.No. 1348 - UB 165 fumarate | C13H15ClN2.C4H4O4 | CAS No. 200432-86-6
Description: Subunit selective nAChR agonist
Chemical Name: 2-(6-Chloro-3-pyridinyl)-9-azabicyclo[4.2.1]non-2-ene fumarate
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Subtype-selective nicotinic agonist. Full agonist at α3β2- and very weak partial agonist at α4β2- containing nAChRs. Ki values are 0.27, 20 (IC50), 2790 and 990 nM for α4β2, α3, α7 and α1β1δε respectively.

Licensing Information

Sold with the permission of the University of Bristol

Technical Data

M. Wt 350.8
Formula C13H15ClN2.C4H4O4
Storage Desiccate at +4°C
Purity ≥99% (HPLC)
CAS Number 200432-86-6
PubChem ID 71297058
InChI Key DZFRKSLRKAKJIB-WLHGVMLRSA-N
Smiles [H]OC(=O)\C=C\C(=O)O[H].ClC1=CC=C(C=N1)C1=CCCC2CCC1N2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 35.08 100mM with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 350.8. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.85 mL 14.25 mL 28.51 mL
5 mM 0.57 mL 2.85 mL 5.7 mL
10 mM 0.29 mL 1.43 mL 2.85 mL
50 mM 0.06 mL 0.29 mL 0.57 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets

Certificate of Analysis / Product Datasheet
Select another batch:
Safety Datasheet

References

References are publications that support the products' biological activity.

Sharples et al (2000) UB-165: a novel agonist with subtype selectivity implicates the α4β2 subtype in the modulation of dopamine release from rat striatal synaptosomes. J.Neurosci. 20 2783 PMID: 10751429

Wright et al (1997) Synthesis of UB-165: a novel nicotinic ligand and anatoxin-a/epibatidine hybrid. Bioorg.Med.Chem.Lett. 7 2867 PMID:

Cao et al (2005) Different nicotinic acetylcholine receptor subtypes mediating striatal and prefrontal cortical [3H]dopamine release. Neuropharmacology 48 72 PMID: 15617729


If you know of a relevant reference for UB 165 fumarate, please let us know.

View Related Products by Product Action

View all Nicotinic Receptor (Other Subtype) Agonists

Keywords: UB 165 fumarate, supplier, Subunit, selective, nAChR, agonists, Acetylcholine, Nicotinic, Receptors, Non-Selective, Subtypes, Other, UB165, Nicotinic, Receptors, (Other, Subtypes), Nicotinic, Receptors, (Other, Subtypes), Tocris Bioscience

Citations for UB 165 fumarate

Citations are publications that use Tocris products.

Currently there are no citations for UB 165 fumarate. Do you know of a great paper that uses UB 165 fumarate from Tocris? If so please let us know.

UB 165 fumarate Reviews

Average Rating:

(Based on 0 Reviews)


1 Star
0%
2 Star
0%
3 Star
0%
4 Star
0%
5 Star
0%

Have you used UB 165 fumarate?

Submit a review and receive a $25US/€18/£15/$25CAN Amazon gift card if you include an image -$10US/€7/£6/$10CAN Amazon gift card for reviews without an image. Limited to verified customers in USA, Canada and Europe.


Literature in this Area

Pain

Pain Research Product Guide

A collection of over 250 products for pain research, the guide includes research tools for the study of:

  • Nociception
  • Ion Channels
  • G-Protein-Coupled Receptors
  • Intracellular Signaling
Nicotinic ACh Receptors

Nicotinic ACh Receptors Scientific Review

Updated in 2014, this review by Sue Wonnacott summarizes the diverse structure and function of nicotinic acetylcholine receptors and gives an in-depth review of the ligands available for nAChR research. Compounds available from Tocris are listed.

Pain

Pain Poster

Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.