UB 165 fumarate

Discontinued Product

UB 165 fumarate (Cat. No. 1348) has been withdrawn from sale for commercial reasons.
Description: Subunit selective nAChR agonist
Chemical Name: 2-(6-Chloro-3-pyridinyl)-9-azabicyclo[4.2.1]non-2-ene fumarate
Purity: ≥99% (HPLC)
Literature (1)

Biological Activity for UB 165 fumarate

UB 165 fumarate is a subtype-selective nicotinic agonist. Full agonist at α3β2- and very weak partial agonist at α4β2- containing nAChRs. Ki values are 0.27, 20 (IC50), 2790 and 990 nM for α4β2, α3, α7 and α1β1δε respectively.

Licensing Information

Sold with the permission of the University of Bristol

Technical Data for UB 165 fumarate

M. Wt 350.8
Formula C13H15ClN2.C4H4O4
Storage Desiccate at +4°C
Purity ≥99% (HPLC)
PubChem ID 71297058
Smiles [H]OC(=O)\C=C\C(=O)O[H].ClC1=CC=C(C=N1)C1=CCCC2CCC1N2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for UB 165 fumarate

Certificate of Analysis / Product Datasheet
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References for UB 165 fumarate

References are publications that support the biological activity of the product.

Sharples et al (2000) UB-165: a novel agonist with subtype selectivity implicates the α4β2 subtype in the modulation of DA release from rat striatal synaptosomes. J.Neurosci. 20 2783 PMID: 10751429

Wright et al (1997) Synthesis of UB-165: a novel nicotinic ligand and anatoxin-a/epibatidine hybrid. Bioorg.Med.Chem.Lett. 7 2867

Cao et al (2005) Different nicotinic acetylcholine receptor subtypes mediating striatal and prefrontal cortical [3H]DA release. Neuropharmacology 48 72 PMID: 15617729

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Keywords: UB 165 fumarate, UB 165 fumarate supplier, Subunit, selective, nAChR, agonists, Acetylcholine, Nicotinic, Receptors, Non-Selective, Subtypes, Other, UB165, 200432-86-6, (Other, Subtypes), 1348, Tocris Bioscience

Citations for UB 165 fumarate

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Currently there are no citations for UB 165 fumarate.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Nicotinic ACh Receptors Scientific Review

Nicotinic ACh Receptors Scientific Review

Updated in 2014, this review by Sue Wonnacott summarizes the diverse structure and function of nicotinic acetylcholine receptors and gives an in-depth review of the ligands available for nAChR research. Compounds available from Tocris are listed.