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UB 165 fumarate
Subtype-selective nicotinic agonist. Full agonist at α3β2- and very weak partial agonist at α4β2- containing nAChRs. Ki values are 0.27, 20 (IC50), 2790 and 990 nM for α4β2, α3, α7 and α1β1δε respectively.
Sold with the permission of the University of Bristol
|Storage||Desiccate at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
|water||35.08||100 with gentle warming|
Preparing Stock Solutions
The following data is based on the product molecular weight 350.8. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.85 mL||14.25 mL||28.51 mL|
|5 mM||0.57 mL||2.85 mL||5.7 mL|
|10 mM||0.29 mL||1.43 mL||2.85 mL|
|50 mM||0.06 mL||0.29 mL||0.57 mL|
References are publications that support the biological activity of the product.
Sharples et al (2000) UB-165: a novel agonist with subtype selectivity implicates the α4β2 subtype in the modulation of DA release from rat striatal synaptosomes. J.Neurosci. 20 2783 PMID: 10751429
Wright et al (1997) Synthesis of UB-165: a novel nicotinic ligand and anatoxin-a/epibatidine hybrid. Bioorg.Med.Chem.Lett. 7 2867
Cao et al (2005) Different nicotinic acetylcholine receptor subtypes mediating striatal and prefrontal cortical [3H]DA release. Neuropharmacology 48 72 PMID: 15617729
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Keywords: UB 165 fumarate, UB 165 fumarate supplier, Subunit, selective, nAChR, agonists, Acetylcholine, Nicotinic, Receptors, Non-Selective, Subtypes, Other, UB165, 200432-86-6, (Other, Subtypes), 1348, Tocris Bioscience
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Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.